Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum
Zhang, Zhi-Jun1,4; Nian, Yin2,3; Zhu, Qin-Feng1,4; Li, Xiao-Nian1; Su, Jia1; Wu, Xing-De1; Yang, Jian2,3; Zhao, Qin-Shi1
2017-09-01
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号19期号:17页码:4668-4671
摘要Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the gamma-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is potent Ca(v)3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 mu M.
关键词Inhibitors Huperzine Channels
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54897
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Ion Channel Res & Drug Dev Ctr, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Zhi-Jun,Nian, Yin,Zhu, Qin-Feng,et al. Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum[J]. ORGANIC LETTERS,2017,19(17):4668-4671.
APA Zhang, Zhi-Jun.,Nian, Yin.,Zhu, Qin-Feng.,Li, Xiao-Nian.,Su, Jia.,...&Zhao, Qin-Shi.(2017).Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum.ORGANIC LETTERS,19(17),4668-4671.
MLA Zhang, Zhi-Jun,et al."Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum".ORGANIC LETTERS 19.17(2017):4668-4671.
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