| Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana | |
Pan, Li-Li1,4; Fang, Ping-Lei1; Zhang, Xing-Jie2,3; Ni, Wei1; Li, Lei1; Yang, Liu-Meng2,3; Chen, Chang-Xiang1 ; Zheng, Yong-Tang2,3; Li, Chang-Tian4; Hao, Xiao-Jiang1; Liu, Hai-Yang1
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| 通讯作者 | Liu, HY (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 2011-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 74期号:6页码:1508-1512 |
| 摘要 | Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC(50) value of 0.02 mu M and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity. |
| 关键词 | Prostratin Activation Roots Hiv-1 |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200058c |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000291920600022 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5487 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China 4.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Li-Li,Fang, Ping-Lei,Zhang, Xing-Jie,et al. Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1508-1512. |
| APA | Pan, Li-Li.,Fang, Ping-Lei.,Zhang, Xing-Jie.,Ni, Wei.,Li, Lei.,...&Liu, Hai-Yang.(2011).Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana.JOURNAL OF NATURAL PRODUCTS,74(6),1508-1512. |
| MLA | Pan, Li-Li,et al."Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1508-1512. |
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