Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana
Pan, Li-Li1,4; Fang, Ping-Lei1; Zhang, Xing-Jie2,3; Ni, Wei1; Li, Lei1; Yang, Liu-Meng2,3; Chen, Chang-Xiang1; Zheng, Yong-Tang2,3; Li, Chang-Tian4; Hao, Xiao-Jiang1; Liu, Hai-Yang1
2011-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:6页码:1508-1512
摘要Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC(50) value of 0.02 mu M and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.
关键词Prostratin Activation Roots Hiv-1
资助信息Young Academic and Technical Leader Raising Foundation of Yunnan Province[2008PY066]; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ02]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200058c
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291920600022
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5487
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
4.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
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Pan, Li-Li,Fang, Ping-Lei,Zhang, Xing-Jie,et al. Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1508-1512.
APA Pan, Li-Li.,Fang, Ping-Lei.,Zhang, Xing-Jie.,Ni, Wei.,Li, Lei.,...&Liu, Hai-Yang.(2011).Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana.JOURNAL OF NATURAL PRODUCTS,74(6),1508-1512.
MLA Pan, Li-Li,et al."Tigliane-Type Diterpenoid Glycosides from Euphorbia fischeriana".JOURNAL OF NATURAL PRODUCTS 74.6(2011):1508-1512.
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