| Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata | |
Feng, Tao3,4; Wang, Rui-Rui1,2; Cai, Xiang-Hai4 ; Zheng, Yong-Tang1,2; Luo, Xiao-Dong4
| |
| 2010-07-01 | |
| 发表期刊 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| ISSN | 0009-2363 |
| 卷号 | 58期号:7页码:971-975 |
| 摘要 | A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65. |
| 关键词 | Poncirus Trifoliata Chemical Constituent Prenylated Flavonoid Anti-human Immunodeficiency Virus-1 Activity |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000279213500019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4112 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,et al. Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975. |
| APA | Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,Zheng, Yong-Tang,&Luo, Xiao-Dong.(2010).Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),971-975. |
| MLA | Feng, Tao,et al."Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):971-975. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 201112280039.pdf（321KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论