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题名: Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata
作者: Feng, Tao3, 4; Wang, Rui-Rui1, 2; null(蔡祥海)4; Zheng, Yong-Tang1, 2; null(罗晓东)4
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
关键词: Poncirus trifoliata ; chemical constituent ; prenylated flavonoid ; anti-human immunodeficiency virus-1 activity
英文摘要: A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65.
出版日期: 2010-07-01
卷号: 58, 期号:7, 页码:971-975
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
ISSN号: 0009-2363
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4112
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Feng, T; Wang, RR; Cai, XH; Zheng, YT; Luo, XD.Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata,CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975
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