Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata
Feng, Tao3,4; Wang, Rui-Rui1,2; Cai, Xiang-Hai4; Zheng, Yong-Tang1,2; Luo, Xiao-Dong4
2010-07-01
Source PublicationCHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
Volume58Issue:7Pages:971-975
AbstractA total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65.
KeywordPoncirus Trifoliata Chemical Constituent Prenylated Flavonoid Anti-human Immunodeficiency Virus-1 Activity
Subject AreaChemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
Indexed BySCI ; IC
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000279213500019
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4112
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,et al. Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975.
APA Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,Zheng, Yong-Tang,&Luo, Xiao-Dong.(2010).Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),971-975.
MLA Feng, Tao,et al."Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):971-975.
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