Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells
Sun, Wei-Hao1; Chen, Guo-Sheng1; Ou, Xi-Long2; Yang, Ye3; Luo, Cheng4,5; Zhang, Yuan1; Shao, Yun1; Xu, Hai-Chen1; Xiao, Bin1; Xue, Yi-Ping1; Zhou, Su-Ming1; Zhao, Qin-Shi4; Ding, Guo-Xian1
2009-03-18
Source PublicationCANCER LETTERS
ISSN0304-3835
Volume275Issue:2Pages:247-255
AbstractAlthough inhibition of cyclooxygenase-2 (COX-2) or activation of peroxisome proliferators-activated receptor gamma (PPAR-gamma) leads to growth inhibition in malignancies, the synergistic anti-tumor effects of combination of COX-2 inhibitor (NS-398) and PPAR-gamma agonist (rosiglitazone) on the human pancreatic cancer cells remains unknown. Here, we evaluated the effects of NS-398 and/or rosiglitazone on the cell proliferation and apoptosis in a pancreatic cancer cell line, SW1990. NS-398 and rosiglitazone decreased cell proliferation in a dose- and time-dependent manner. Proliferating cell nuclear antigen (PCNA) labeling index significantly decreased in the cells treated with either NS-398 or rosiglitazone. Both NS-398 and rosiglitazone alone induced apoptotic cell death of SW1990. The combination of NS-398 and rosiglitazone exerted synergistic effects on proliferation inhibition, and apoptosis induction in SW1990 cells. with down-regulation of Bcl-2 and up-regulation of Bax expression. Our results indicate that simultaneous targeting of COX-2 and PPAR-gamma inhibits pancreatic cancer development more effectively than targeting each molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
KeywordPancreatic Cancer Cyclooxygenase-2 Peroxisome Proliferators-activated Receptor Gamma Proliferation Apoptosis
Subject AreaOncology
DOI10.1016/j.canlet.2008.10.023
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000264037600013
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2903
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu Prov, Peoples R China
2.Southeast Univ, Affiliated Zhongda Hosp, Dept Gastroenterol, Nanjing 210009, Jiangsu, Peoples R China
3.Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
5.Univ Turku, Inst Biomed, FIN-20520 Turku, Finland
Recommended Citation
GB/T 7714
Sun, Wei-Hao,Chen, Guo-Sheng,Ou, Xi-Long,et al. Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells[J]. CANCER LETTERS,2009,275(2):247-255.
APA Sun, Wei-Hao.,Chen, Guo-Sheng.,Ou, Xi-Long.,Yang, Ye.,Luo, Cheng.,...&Ding, Guo-Xian.(2009).Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells.CANCER LETTERS,275(2),247-255.
MLA Sun, Wei-Hao,et al."Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells".CANCER LETTERS 275.2(2009):247-255.
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