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题名: Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells via PI3K/AKT and NF-kappa B signaling pathways
作者: Leung, Hoi-Wing2, 3; Wang, Zhe1, 5; Yue, Grace Gar-Lee2, 3; Zhao, Si-Meng1, 5; Lee, Julia Kin-Ming2, 3; Fung, Kwok-Pui2, 3, 4; Leung, Ping-Chung2, 3; Lau, Clara Bik-San2, 3; Tan, Ning-Hua1
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
出版日期: 2015-08-01
卷号: 1853, 期号:8, 页码:1827-1840
关键词: Cyclopeptide ; Cell adhesion ; Cell invasion ; Metastasis ; Breast cancer
学科分类: Biochemistry & Molecular Biology; Cell Biology
DOI: 10.1016/j.bbamcr.2015.04.020
通讯作者: Lau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China. ; claralau@cuhk.edu.hk ; nhtan@mail.kib.ac.cn
文章类型: Article
英文摘要: Cyclopeptide RA-V has potent anti-tumor and anti-angiogenic activities, but its potential anti-metastatic activity is unknown. Cancer cells acquire invasive ability to degrade and adhere to extracellular matrix (ECM), allowing them to migrate to adjacent tissues and ultimately metastasize. Hence, the present study aimed to investigate the effects of RA-V on cell adhesion, migration, invasion and matrix degradation, and its underlying mechanism in two human breast cancer cell lines MCF-7 (ER-positive) and MDA-MB-231 (ER-negative). Our results demonstrated that RA-V (12.5 nM) can significantly inhibit breast cancer cell adhesion and migration via interfering cofilin signaling and chemokine receptors involved in cell migration. RA-V reduced the expressions of vascular intracellular adhesion molecule (VCAM), intracellular adhesion molecule (ICAM), focal adhesion kinase (FAR) and integrins. The activities and expressions of matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs) and urokinase-type of plasminogen activator (uPA) were also inhibited by RA-V. Furthermore, RA-V inhibits the expressions of EGFR, PI3K/AKT and NF-kappa B signaling molecules, and reduces the binding of beta-estradiol to ER via affecting binding ability of ER in MCF-7 cells. RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitro, implying that RA-V is a potential anti-metastatic agent in breast cancer, and likely acts via PI3K/AKT and NF-kappa B signaling pathways in both ER-positive and ER-negative breast cancer cells. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: ANTITUMOR CYCLIC HEXAPEPTIDES ; MATRIX METALLOPROTEINASES ; PLASMINOGEN-ACTIVATOR ; RUBIA-YUNNANENSIS ; TISSUE INHIBITOR ; OVER-EXPRESSION ; METASTASIS ; MIGRATION ; KINASE ; LUNG
收录类别: SCI
项目资助者: National Natural Science Foundation of China [U1032602, 91013002, 30725048] ; Foundation of Chinese Academy of Sciences (Hundred Talents Program) [XDA09030301-4] ; State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from Hong Kong Special Administrative Region ; Chinese University of Hong Kong (FIS-A) [1907014]
语种: 英语
WOS记录号: WOS:000356209600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21357
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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