| Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis | |
Wen, Yan-Shi1,2; Ni, Wei1; Qin, Xu-Jie1 ; Yan, Huan1; Chen, Chang-Xiang1; Hua, Yan2; Cheng, Yung-Chi3; He, Li4; Liu, Hai-Yang1; Liu,HY (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; haiyangliu@mail.kib.ac.cn
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| 2015-06-01 | |
| 发表期刊 | PHYTOCHEMISTRY LETTERS
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| 卷号 | 12页码:31-34 |
| 摘要 | Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| 关键词 | Paris Polyphylla Var. Yunnanensis Steroidal Saponins Dianchonglouoside a Dianchonglouoside b Cytotoxic Activity |
| 学科领域 | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytol.2015.02.011 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356336400007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21335 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Liu,HY (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; haiyangliu@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southwest Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China 3.Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA 4.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Yan-Shi,Ni, Wei,Qin, Xu-Jie,et al. Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis[J]. PHYTOCHEMISTRY LETTERS,2015,12:31-34. |
| APA | Wen, Yan-Shi.,Ni, Wei.,Qin, Xu-Jie.,Yan, Huan.,Chen, Chang-Xiang.,...&haiyangliu@mail.kib.ac.cn.(2015).Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis.PHYTOCHEMISTRY LETTERS,12,31-34. |
| MLA | Wen, Yan-Shi,et al."Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis".PHYTOCHEMISTRY LETTERS 12(2015):31-34. |
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