Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis
Wen, Yan-Shi1,2; Ni, Wei1; Qin, Xu-Jie1; Yan, Huan1; Chen, Chang-Xiang1; Hua, Yan2; Cheng, Yung-Chi3; He, Li4; Liu, Hai-Yang1; Liu,HY (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; haiyangliu@mail.kib.ac.cn
2015-06-01
发表期刊PHYTOCHEMISTRY LETTERS
卷号12页码:31-34
摘要Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Paris Polyphylla Var. Yunnanensis Steroidal Saponins Dianchonglouoside a Dianchonglouoside b Cytotoxic Activity
资助信息Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004-03-4]; National Natural Science Funding of China [31170333]; Innovation Team of the Ministry of Education [IRT13067]; Scientific and Technological Projects of Yunnan Province [2014IB008]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytol.2015.02.011
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000356336400007
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21335
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu,HY (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; haiyangliu@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southwest Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China
3.Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
4.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
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GB/T 7714
Wen, Yan-Shi,Ni, Wei,Qin, Xu-Jie,et al. Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis[J]. PHYTOCHEMISTRY LETTERS,2015,12:31-34.
APA Wen, Yan-Shi.,Ni, Wei.,Qin, Xu-Jie.,Yan, Huan.,Chen, Chang-Xiang.,...&haiyangliu@mail.kib.ac.cn.(2015).Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis.PHYTOCHEMISTRY LETTERS,12,31-34.
MLA Wen, Yan-Shi,et al."Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis".PHYTOCHEMISTRY LETTERS 12(2015):31-34.
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