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题名: Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis
作者: Wen, Yan-Shi1, 2; Ni, Wei1; Qin, Xu-Jie1; Yan, Huan1; Chen, Chang-Xiang1; Hua, Yan2; Cheng, Yung-Chi3; He, Li4; null(刘海洋)1
刊名: PHYTOCHEMISTRY LETTERS
关键词: Paris polyphylla var. yunnanensis ; Steroidal saponins ; Dianchonglouoside A ; Dianchonglouoside B ; Cytotoxic activity
英文摘要: Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
出版日期: 2015-06-01
卷号: 12, 页码:31-34
DOI标识: 10.1016/j.phytol.2015.02.011
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21335
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southwest Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China
3.Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
4.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
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