Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo
Cheng, Bao-Hui1,2; Zhou, Xuelin1,2; Wang, Yan3; Chan, Judy Yuet-Wa1,2; Lin, Huang-Quan1,2; Or, Penelope M. Y.4; Wan, David Chi-Cheong4; Leung, Ping-Chung1,2; Fung, Kwok-Pui1,2,4; Wang, Yi-Fen5; Lau, Clara Bik-San1,2; Lau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China.; claralau@cuhk.edu.hk
2015-03-13
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
Volume162Pages:369-376
AbstractEthnopharmacological relevance: With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably decreased. With long-term use of HAART, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. Traditional herbal medicine has become more popular among HIV/AIDS patients as adjuvant therapy to reduce these adverse effects of HAART. SH formula is a Chinese herbal formula consisting of five traditional Chinese herbs including Morus alba L, Glycyrrhiza glabra L, Artemisia capillaris Thumb., Astragalus membranaceus Bge., and Carthamus tinctorius L. SH formula is clinically used for HIV treatment in Thailand. However, the possible pharmacokinetic interactions between these Chinese herbs and antiretroviral drugs have not been well documented. The aim of this study was to investigate the potential herb-drug interaction between SH herbal Chinese formula and the antiretroviral drug atazanavir (ATV).
KeywordSh Formula Atazanavir Anti-hiv Cyp3a2 Herb-drug Interaction
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.1016/j.jep.2015.01.010
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000351323400047
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20581
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China.; claralau@cuhk.edu.hk
Affiliation1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
4.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Bao-Hui,Zhou, Xuelin,Wang, Yan,et al. Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,162:369-376.
APA Cheng, Bao-Hui.,Zhou, Xuelin.,Wang, Yan.,Chan, Judy Yuet-Wa.,Lin, Huang-Quan.,...&claralau@cuhk.edu.hk.(2015).Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo.JOURNAL OF ETHNOPHARMACOLOGY,162,369-376.
MLA Cheng, Bao-Hui,et al."Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo".JOURNAL OF ETHNOPHARMACOLOGY 162(2015):369-376.
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