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题名: Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo
作者: Cheng, Bao-Hui1, 2; Zhou, Xuelin1, 2; Wang, Yan3; Chan, Judy Yuet-Wa1, 2; Lin, Huang-Quan1, 2; Or, Penelope M. Y.4; Wan, David Chi-Cheong4; Leung, Ping-Chung1, 2; Fung, Kwok-Pui1, 2, 4; null(王易芬)5; Lau, Clara Bik-San1, 2
刊名: JOURNAL OF ETHNOPHARMACOLOGY
出版日期: 2015-03-13
卷号: 162, 页码:369-376
关键词: SH formula ; Atazanavir ; Anti-HIV ; CYP3A2 ; Herb-drug interaction
学科分类: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
DOI: 10.1016/j.jep.2015.01.010
通讯作者: Lau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China. ; claralau@cuhk.edu.hk
文章类型: Article
英文摘要: Ethnopharmacological relevance: With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably decreased. With long-term use of HAART, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. Traditional herbal medicine has become more popular among HIV/AIDS patients as adjuvant therapy to reduce these adverse effects of HAART. SH formula is a Chinese herbal formula consisting of five traditional Chinese herbs including Morus alba L, Glycyrrhiza glabra L, Artemisia capillaris Thumb., Astragalus membranaceus Bge., and Carthamus tinctorius L. SH formula is clinically used for HIV treatment in Thailand. However, the possible pharmacokinetic interactions between these Chinese herbs and antiretroviral drugs have not been well documented. The aim of this study was to investigate the potential herb-drug interaction between SH herbal Chinese formula and the antiretroviral drug atazanavir (ATV).
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; PROTEASE ; METABOLISM ; CYP3A4 ; CYP2D6
收录类别: SCI
项目资助者: grant of the State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from HKSAR ; grant of the State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from CUHK ; Focused Innovations Scheme (Major Area Scheme A - Phase 2) of The Chinese University of Hong Kong
语种: 英语
WOS记录号: WOS:000351323400047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20581
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
4.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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