The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia
Chen, Jian-Chao1; Lau, Clara Bik-San2,3; Chan, Judy Yuet-Wa2,3; Fung, Kwok-Pui2,3; Leung, Ping-Chung2,3; Liu, Jie-Qing1; Zhou, Lin1; Xie, Ming-Jin4; Qiu, Ming-Hua1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; claralau@cuhk.edu.hk; mhchiu@mail.kib.ac.cn
2015-03-01
Source PublicationPLANTA MEDICA
Volume81Issue:4Pages:327-332
AbstractFive new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5 beta, 19-epoxycucurbit-23-en-7-on-3 beta, 25-diol (1), 5 beta, 19-epoxycucurbit-7,23-dion-3 beta, 25-diol (2), 5 beta, 19-epoxycucurbit-6-en-19,23-dion3 beta, 25-diol (3), 5 beta, 19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3 beta, 22-diol (4), and cucurbit-5-en-7,23-dion-3 beta, 19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 mu M) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 mu M) showed around 20-30% inhibition on PEPCK activity.
KeywordMomordica Charantia Cucurbitaceae Cucurbitacin Kuguacins Ii-vi Antigluconeogenic Activity Pepck Activity
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-0035-1545695
Indexed BySCI
Language英语
WOS IDWOS:000350747900010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20580
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; claralau@cuhk.edu.hk; mhchiu@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.State Key Lab Phytochem & Plant Resources West Ch, Hong Kong, Hong Kong, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jian-Chao,Lau, Clara Bik-San,Chan, Judy Yuet-Wa,et al. The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia[J]. PLANTA MEDICA,2015,81(4):327-332.
APA Chen, Jian-Chao.,Lau, Clara Bik-San.,Chan, Judy Yuet-Wa.,Fung, Kwok-Pui.,Leung, Ping-Chung.,...&mhchiu@mail.kib.ac.cn.(2015).The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia.PLANTA MEDICA,81(4),327-332.
MLA Chen, Jian-Chao,et al."The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia".PLANTA MEDICA 81.4(2015):327-332.
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