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题名: The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia
作者: Chen, Jian-Chao1; Lau, Clara Bik-San2, 3; Chan, Judy Yuet-Wa2, 3; Fung, Kwok-Pui2, 3; Leung, Ping-Chung2, 3; Liu, Jie-Qing1; Zhou, Lin1; Xie, Ming-Jin4; null(邱明华)1
刊名: PLANTA MEDICA
出版日期: 2015-03-01
卷号: 81, 期号:4, 页码:327-332
关键词: Momordica charantia ; Cucurbitaceae ; cucurbitacin ; kuguacins II-VI ; antigluconeogenic activity ; PEPCK activity
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
DOI: 10.1055/s-0035-1545695
通讯作者: Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; claralau@cuhk.edu.hk ; mhchiu@mail.kib.ac.cn
文章类型: Article
英文摘要: Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5 beta, 19-epoxycucurbit-23-en-7-on-3 beta, 25-diol (1), 5 beta, 19-epoxycucurbit-7,23-dion-3 beta, 25-diol (2), 5 beta, 19-epoxycucurbit-6-en-19,23-dion3 beta, 25-diol (3), 5 beta, 19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3 beta, 22-diol (4), and cucurbit-5-en-7,23-dion-3 beta, 19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 mu M) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 mu M) showed around 20-30% inhibition on PEPCK activity.
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: ISOLATED MAJOR COMPOUNDS ; TRITERPENOIDS ; GLYCOSIDES ; CANCER ; LEAVES ; FRUITS
收录类别: SCI
项目资助者: NSFC [81373288] ; Natural Science Foundation of Yunnan Province [2008CD158] ; Western Doctoral Foundation of Chinese Academy of Sciences ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences [P2008ZZ23, P2010ZZ14] ; Cooperative Project of Guangdong Province [2009B091300135] ; Cooperative Project of CAS [2009B091300135] ; State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from the Hong Kong Special Administrative Region ; State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from CUHK ; Focused Innovations Scheme (Major Area Scheme A - Phase 2) of the Chinese University of Hong Kong
语种: 英语
WOS记录号: WOS:000350747900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20580
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.State Key Lab Phytochem & Plant Resources West Ch, Hong Kong, Hong Kong, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Kunming, Peoples R China
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