The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia
Chen, Jian-Chao1; Lau, Clara Bik-San2,3; Chan, Judy Yuet-Wa2,3; Fung, Kwok-Pui2,3; Leung, Ping-Chung2,3; Liu, Jie-Qing1; Zhou, Lin1; Xie, Ming-Jin4; Qiu, Ming-Hua1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; claralau@cuhk.edu.hk; mhchiu@mail.kib.ac.cn
2015-03-01
发表期刊PLANTA MEDICA
卷号81期号:4页码:327-332
摘要Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5 beta, 19-epoxycucurbit-23-en-7-on-3 beta, 25-diol (1), 5 beta, 19-epoxycucurbit-7,23-dion-3 beta, 25-diol (2), 5 beta, 19-epoxycucurbit-6-en-19,23-dion3 beta, 25-diol (3), 5 beta, 19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3 beta, 22-diol (4), and cucurbit-5-en-7,23-dion-3 beta, 19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 mu M) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 mu M) showed around 20-30% inhibition on PEPCK activity.
关键词Momordica Charantia Cucurbitaceae Cucurbitacin Kuguacins Ii-vi Antigluconeogenic Activity Pepck Activity
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-0035-1545695
收录类别SCI
语种英语
WOS记录号WOS:000350747900010
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20580
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; claralau@cuhk.edu.hk; mhchiu@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.State Key Lab Phytochem & Plant Resources West Ch, Hong Kong, Hong Kong, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Kunming, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jian-Chao,Lau, Clara Bik-San,Chan, Judy Yuet-Wa,et al. The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia[J]. PLANTA MEDICA,2015,81(4):327-332.
APA Chen, Jian-Chao.,Lau, Clara Bik-San.,Chan, Judy Yuet-Wa.,Fung, Kwok-Pui.,Leung, Ping-Chung.,...&mhchiu@mail.kib.ac.cn.(2015).The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia.PLANTA MEDICA,81(4),327-332.
MLA Chen, Jian-Chao,et al."The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia".PLANTA MEDICA 81.4(2015):327-332.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Chen-2015-The Antigl(142KB) 开放获取CC BY-NC-ND浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Jian-Chao]的文章
[Lau, Clara Bik-San]的文章
[Chan, Judy Yuet-Wa]的文章
百度学术
百度学术中相似的文章
[Chen, Jian-Chao]的文章
[Lau, Clara Bik-San]的文章
[Chan, Judy Yuet-Wa]的文章
必应学术
必应学术中相似的文章
[Chen, Jian-Chao]的文章
[Lau, Clara Bik-San]的文章
[Chan, Judy Yuet-Wa]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Chen-2015-The Antigluconeogenic Activity of Cu.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。