Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
Zhu, Hucheng1; Chen, Chunmei1; Yang, Jing2,3; Li, Xiao-Nian2; Liu, Junjun1; Sun, Bin1; Huang, Sheng-Xiong2; Li, Dongyan4; Yao, Guangmin1; Luo, Zengwei1; Li, Yan2; Zhang, Jinwen4; Xue, Yongbo1; Zhang, Yonghui1
2014-12-19
Source PublicationORGANIC LETTERS
Volume16Issue:24Pages:6322-6325
AbstractHyperisampsins AD (1-4), with tetracyclo[6.3.1.1(3,10).0(3,7)]tridecane skeletons and seven biogenetically related congeners (5=11), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established by ECD calculations, and those of 5 and 9 were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 mu M and selectivity index of 4.80 and 7.70, respectively.
DOI10.1021/ol5030579
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000346759900015
Citation statistics
Cited Times:55[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20472
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Hucheng,Chen, Chunmei,Yang, Jing,et al. Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii[J]. ORGANIC LETTERS,2014,16(24):6322-6325.
APA Zhu, Hucheng.,Chen, Chunmei.,Yang, Jing.,Li, Xiao-Nian.,Liu, Junjun.,...&Zhang, Yonghui.(2014).Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii.ORGANIC LETTERS,16(24),6322-6325.
MLA Zhu, Hucheng,et al."Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii".ORGANIC LETTERS 16.24(2014):6322-6325.
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