Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii

doi:10.1021/ol5030579

	Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
	Zhu, Hucheng 1; Chen, Chunmei 1; Yang, Jing2,3 ; Li, Xiao-Nian 2; Liu, Junjun 1; Sun, Bin 1; Huang, Sheng-Xiong2 ; Li, Dongyan 4; Yao, Guangmin 1; Luo, Zengwei 1; Li, Yan2 ; Zhang, Jinwen 4; Xue, Yongbo 1; Zhang, Yonghui 1
	2014-12-19
发表期刊	ORGANIC LETTERS
卷号	16 期号:24 页码:6322-6325
摘要	Hyperisampsins AD (1-4), with tetracyclo[6.3.1.1(3,10).0(3,7)]tridecane skeletons and seven biogenetically related congeners (5=11), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established by ECD calculations, and those of 5 and 9 were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 mu M and selectivity index of 4.80 and 7.70, respectively.
DOI	10.1021/ol5030579
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000346759900015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/20472
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Hucheng,Chen, Chunmei,Yang, Jing,et al. Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii[J]. ORGANIC LETTERS,2014,16(24):6322-6325.
APA	Zhu, Hucheng.,Chen, Chunmei.,Yang, Jing.,Li, Xiao-Nian.,Liu, Junjun.,...&Zhang, Yonghui.(2014).Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii.ORGANIC LETTERS,16(24),6322-6325.
MLA	Zhu, Hucheng,et al."Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii".ORGANIC LETTERS 16.24(2014):6322-6325.

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