Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum
Cheng, Yuan-Yuan1,2; Chen, Huan2,3; He, Hong-Ping1; Zhang, Yu1; Li, Shi-Fei1,2; Tang, Gui-Hua1,2; Guo, Ling-Li1; Yang, Wei1,2; Zhu, Feng1,2; Zheng, Yong-Tang3; Li, Shun-Lin1; Hao, Xiao-Jiang1
2013-12-01
Source PublicationPHYTOCHEMISTRY
Volume96Pages:360-369
AbstractSixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thy rsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordTrigonostemon Thyrsoideum Euphorbiaceae Daphnane Diterpenoids Trigothysoids A-p Anti-hiv-1
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000328869500038
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/19233
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Yuan-Yuan,Chen, Huan,He, Hong-Ping,et al. Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum[J]. PHYTOCHEMISTRY,2013,96:360-369.
APA Cheng, Yuan-Yuan.,Chen, Huan.,He, Hong-Ping.,Zhang, Yu.,Li, Shi-Fei.,...&Hao, Xiao-Jiang.(2013).Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.PHYTOCHEMISTRY,96,360-369.
MLA Cheng, Yuan-Yuan,et al."Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum".PHYTOCHEMISTRY 96(2013):360-369.
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