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题名: Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum
作者: Cheng, Yuan-Yuan1, 2; Chen, Huan2, 3; He, Hong-Ping1; Zhang, Yu1; Li, Shi-Fei1, 2; Tang, Gui-Hua1, 2; null(郭伶俐)1; Yang, Wei1, 2; Zhu, Feng1, 2; Zheng, Yong-Tang3; Li, Shun-Lin1; null(郝小江)1
刊名: PHYTOCHEMISTRY
出版日期: 2013-12-01
卷号: 96, 页码:360-369
关键词: Trigonostemon thyrsoideum ; Euphorbiaceae ; Daphnane diterpenoids ; Trigothysoids A-P ; Anti-HIV-1
文章类型: Article
英文摘要: Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thy rsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619. (C) 2013 Elsevier Ltd. All rights reserved.
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: IN-VITRO ; A-G ; REIDIOIDES ; POTENT ; CHINENSIS ; TRICHOSANTHIN ; CONSTITUENTS ; INHIBITORS ; REDIOCIDE ; HOWII
收录类别: SCI ; IC
语种: 英语
WOS记录号: WOS:000328869500038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19233
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
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