Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum
Cheng, Yuan-Yuan1,2; Chen, Huan2,3; He, Hong-Ping1; Zhang, Yu1; Li, Shi-Fei1,2; Tang, Gui-Hua1,2; Guo, Ling-Li1; Yang, Wei1,2; Zhu, Feng1,2; Zheng, Yong-Tang3; Li, Shun-Lin1; Hao, Xiao-Jiang1
2013-12-01
发表期刊PHYTOCHEMISTRY
卷号96页码:360-369
摘要Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thy rsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Trigonostemon Thyrsoideum Euphorbiaceae Daphnane Diterpenoids Trigothysoids A-p Anti-hiv-1
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000328869500038
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19233
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China
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Cheng, Yuan-Yuan,Chen, Huan,He, Hong-Ping,et al. Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum[J]. PHYTOCHEMISTRY,2013,96:360-369.
APA Cheng, Yuan-Yuan.,Chen, Huan.,He, Hong-Ping.,Zhang, Yu.,Li, Shi-Fei.,...&Hao, Xiao-Jiang.(2013).Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.PHYTOCHEMISTRY,96,360-369.
MLA Cheng, Yuan-Yuan,et al."Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum".PHYTOCHEMISTRY 96(2013):360-369.
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