Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Chenggong Campus,Kunming 650050,Yunnan,Peoples R China.
Two new monoterpenoid indole alkaloids, vincamajorines A (1) and B (2), were isolated from Vinca major. Their structures were elucidated by means of 1D and 2D NMR, and HREIMS spectroscopic data. The relative and absolute configurations were deduced by comparing the experimental C-13 NMR, ECD spectra, and OR data with those theoretically calculated. Vincamajorine A (1) represents a new C-20 carbon skeleton arranged compactly in seven rings, and vincamajorine B(2) is an alkaloid with an unprecedented 6/5/7/5/6 pentacyclic ring system. A possible biosynthetic pathway was also proposed for the formation of 1 and 2. (C) 2014 Elsevier Ltd. All rights reserved.
National Natural Science Foundation of China [31320103919, 31300199]
; National Key Basic Research Program of China [2014CB954100]
; Key Research Program of the Chinese Academy of Sciences [KJZD-EW-L07]
; Natural Science Foundation of Yunnan Province [2011FB101]
; Western Light Project of the Chinese Academy of Sciences [292013312D11015]
1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
Zhang,Zhi-Jun;Yang,Jing;He,Juan;Wu,Xing-De;Shao,Li-Dong;Li,Yan;Huang,Sheng-Xiong;Li,Rong-Tao;Zhao,Qin-Shi.Vincamajorines A and B, monoterpenoid indole alkaloids with new carbon skeletons from Vinca major,TETRAHEDRON LETTERS,2014,176(3):421-433