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题名: Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro
作者: Sun, Wei-Hao1; Zhu, Feng2; Chen, Guo-Sheng1; Su, Han3; Luo, Cheng4, 5; null(赵勤实)4; Zhang, Yuan1; Shao, Yun1; Sun, Jian6; Zhou, Su-Ming1; Ding, Guo-Xian1; Cheng, Yun-Lin1
刊名: CANCER LETTERS
关键词: cholecystokinin-2 receptor ; cyclooxygenase-2 ; MKN-45 cell ; proliferation ; apoptosis
英文摘要: Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
出版日期: 2008-05-18
卷号: 263, 期号:2, 页码:302-311
DOI标识: 10.1016/j.canlet.2008.01.012
语种: 英语
ISSN号: 0304-3835
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1841
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China
2.Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China
3.Govt Off Hosp Jiangsu Prov Peoples Govt, Dept Med, Nanjing 210024, Jiangsu, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
5.Univ Turku, Inst Biomed, FIN-20520 Turku, Finland
6.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Sun, WH; Zhu, F; Chen, GS; Su, H; Luo, C; Zhao, QS; Zhang, Y; Shao, Y; Sun, J; Zhou, SM; Ding, GX; Cheng, YL.Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro,CANCER LETTERS,2008,263(2):302-311
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