Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro

doi:10.1016/j.canlet.2008.01.012

	Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro
	Sun, Wei-Hao 1; Zhu, Feng 2; Chen, Guo-Sheng 1; Su, Han 3; Luo, Cheng 4,5; Zhao, Qin-Shi4 ; Zhang, Yuan 1; Shao, Yun 1; Sun, Jian 6; Zhou, Su-Ming 1; Ding, Guo-Xian 1; Cheng, Yun-Lin 1
	2008-05-18
发表期刊	CANCER LETTERS
ISSN	0304-3835
卷号	263 期号:2 页码:302-311
摘要	Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词	Cholecystokinin-2 Receptor Cyclooxygenase-2 Mkn-45 Cell Proliferation Apoptosis
学科领域	Oncology
DOI	10.1016/j.canlet.2008.01.012
收录类别	SCI
语种	英语
WOS记录号	WOS:000255810500017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1841
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China 2.Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China 3.Govt Off Hosp Jiangsu Prov Peoples Govt, Dept Med, Nanjing 210024, Jiangsu, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 5.Univ Turku, Inst Biomed, FIN-20520 Turku, Finland 6.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Sun, Wei-Hao,Zhu, Feng,Chen, Guo-Sheng,et al. Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro[J]. CANCER LETTERS,2008,263(2):302-311.
APA	Sun, Wei-Hao.,Zhu, Feng.,Chen, Guo-Sheng.,Su, Han.,Luo, Cheng.,...&Cheng, Yun-Lin.(2008).Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro.CANCER LETTERS,263(2),302-311.
MLA	Sun, Wei-Hao,et al."Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro".CANCER LETTERS 263.2(2008):302-311.

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