Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro
Sun, Wei-Hao1; Zhu, Feng2; Chen, Guo-Sheng1; Su, Han3; Luo, Cheng4,5; Zhao, Qin-Shi4; Zhang, Yuan1; Shao, Yun1; Sun, Jian6; Zhou, Su-Ming1; Ding, Guo-Xian1; Cheng, Yun-Lin1
2008-05-18
发表期刊CANCER LETTERS
ISSN0304-3835
卷号263期号:2页码:302-311
摘要Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词Cholecystokinin-2 Receptor Cyclooxygenase-2 Mkn-45 Cell Proliferation Apoptosis
学科领域Oncology
DOI10.1016/j.canlet.2008.01.012
收录类别SCI
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000255810500017
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1841
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China
2.Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China
3.Govt Off Hosp Jiangsu Prov Peoples Govt, Dept Med, Nanjing 210024, Jiangsu, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
5.Univ Turku, Inst Biomed, FIN-20520 Turku, Finland
6.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
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Sun, Wei-Hao,Zhu, Feng,Chen, Guo-Sheng,et al. Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro[J]. CANCER LETTERS,2008,263(2):302-311.
APA Sun, Wei-Hao.,Zhu, Feng.,Chen, Guo-Sheng.,Su, Han.,Luo, Cheng.,...&Cheng, Yun-Lin.(2008).Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro.CANCER LETTERS,263(2),302-311.
MLA Sun, Wei-Hao,et al."Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro".CANCER LETTERS 263.2(2008):302-311.
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