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题名: Eriocalyxin B-Induced Apoptosis in Pancreatic Adenocarcinoma Cells Through Thiol-Containing Antioxidant Systems and Downstream Signalling Pathways
作者: Li, L.1, 2, 3; Yue, G. G. L.2, 3; Pu, J. X.4; Sun, H. D.4; Fung, K. P.1, 2, 3; Leung, P. C.2, 3; Han, Q. B.5; Lau, C. B. S.2, 3; Leung, P. S.1
刊名: CURRENT MOLECULAR MEDICINE
出版日期: 2014
卷号: 14, 期号:5, 页码:673-689
关键词: Apoptosis ; eriocalyxin B ; pancreatic cancer ; reactive oxygen species ; thiols
学科分类: Medicine, Research & Experimental
通讯作者: Xu, JC (reprint author), Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China. ; j.c.xu@cgiar.org ; kdhyde3@gmail.com
文章类型: Article
英文摘要: Thiol-containing antioxidant systems play an important role in regulating cellular redox homeostasis. Several anti-cancer agents act by targeting these systems by inducing the production of reactive oxygen species (ROS). Our earlier studies have shown that Eriocalyxin B (EriB), a diterpenoid isolated from Isodon eriocalyx, possesses anti-pancreatic tumour activities in vitro and in vivo. The present study further demonstrated that only thiol-containing antioxidants, N-acetylcysteine (NAC) or dithiothreitol (DTT), inhibited EriB-induced cytotoxicity and apoptosis. EriB suppressed the glutathione and thioredoxin antioxidant systems, thus increasing the intracellular ROS levels and regulating the MAPK, NF kappa B pathways. Treatment with EriB depleted the intracellular thiol-containing proteins in CAPAN-2 cells. In vivo studies also showed that EriB treatment (2.5 mg/kg) reduced the pancreatic tumour weights significantly in nude mice with increased superoxide levels. Taken together, our results shed important new light on the molecular mechanisms of EriB acting as an apoptogenic agent and its therapeutic potential for pancreatic cancer.
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: FACTOR-KAPPA-B ; OXIDATIVE STRESS ; THIOREDOXIN REDUCTASE ; CANCER CELLS ; MAMMALIAN THIOREDOXIN ; REDOX REGULATION ; TUMOR-GROWTH ; IN-VITRO ; INHIBITION ; GLUTATHIONE
收录类别: SCI
语种: 英语
WOS记录号: WOS:000338528100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18277
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Hong Kong, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Mengla, Yunnan, Peoples R China
5.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Li,L.;Yue,G.G. L.;Pu,J.X.;Sun,H.D.;Fung,K.P.;Leung,P.C.;Han,Q.B.;Lau,C.B.S.;Leung,P.S..Eriocalyxin B-Induced Apoptosis in Pancreatic Adenocarcinoma Cells Through Thiol-Containing Antioxidant Systems and Downstream Signalling Pathways,CURRENT MOLECULAR MEDICINE,2014,14(5):673-689
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