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题名: Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells
作者: Yan, Chen1, 2, 3; Huang, Li4; Liu, Hong-Chun5; Chen, Duo-Zhi1; null(刘海洋)1; Li, Xiao-Hui1; Zhang, Yu1; Geng, Mei-Yu5; Chen, Quan4; null(郝小江)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Spiramine derivative ; alpha,beta-Unsaturated ketone ; Bax(-/-)/Bak(-/-) cells ; Apoptosis ; Cytotoxicity
英文摘要: Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved.
出版日期: 2014-04-15
卷号: 24, 期号:8, 页码:1884-1888
语种: 英语
收录类别: SCI ; IC
学科分类: Pharmacology & Pharmacy ; Chemistry
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18127
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

Recommended Citation:
Yan,Chen;Huang,Li;Liu,Hong-Chun;Chen,Duo-Zhi;Liu,Hai-Yang;Li,Xiao-Hui;Zhang,Yu;Geng,Mei-Yu;Chen,Quan;Hao,Xiao-Jiang.Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(8):1884-1888
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