| Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells | |
Yan, Chen1,2,3; Huang, Li4 ; Liu, Hong-Chun5; Chen, Duo-Zhi1; Liu, Hai-Yang1; Li, Xiao-Hui1; Zhang, Yu1; Geng, Mei-Yu5; Chen, Quan4; Hao, Xiao-Jiang1
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| 通讯作者 | Chen,Q (reprint author),Chinese Acad Sci,Inst Zool,State Key Lab Biomembrane & Membrane Biotechnol,Beijing 100101,Peoples R China. ; chenq@ioz.ac.cn ; haoxj@mail.kib.ac.cn |
| 2014-04-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 24期号:8页码:1884-1888 |
| 摘要 | Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Spiramine Derivative Bax(-/-)/bak(-/-) Cells Alpha Apoptosis Beta-unsaturated Ketone Cytotoxicity |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2014.03.019 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000333579500004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18127 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Chen,Huang, Li,Liu, Hong-Chun,et al. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(8):1884-1888. |
| APA | Yan, Chen.,Huang, Li.,Liu, Hong-Chun.,Chen, Duo-Zhi.,Liu, Hai-Yang.,...&Hao, Xiao-Jiang.(2014).Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(8),1884-1888. |
| MLA | Yan, Chen,et al."Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.8(2014):1884-1888. |
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