Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells
Yan, Chen1,2,3; Huang, Li4; Liu, Hong-Chun5; Chen, Duo-Zhi1; Liu, Hai-Yang1; Li, Xiao-Hui1; Zhang, Yu1; Geng, Mei-Yu5; Chen, Quan4; Hao, Xiao-Jiang1
2014-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号24期号:8页码:1884-1888
摘要Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Spiramine Derivative Bax(-/-)/bak(-/-) Cells Alpha Apoptosis Beta-unsaturated Ketone Cytotoxicity
资助信息National Natural Science Foundation of China [U1032603]
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2014.03.019
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000333579500004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18127
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Yan, Chen,Huang, Li,Liu, Hong-Chun,et al. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(8):1884-1888.
APA Yan, Chen.,Huang, Li.,Liu, Hong-Chun.,Chen, Duo-Zhi.,Liu, Hai-Yang.,...&Hao, Xiao-Jiang.(2014).Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(8),1884-1888.
MLA Yan, Chen,et al."Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.8(2014):1884-1888.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yan-2014-Spiramine d(1562KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yan, Chen]的文章
[Huang, Li]的文章
[Liu, Hong-Chun]的文章
百度学术
百度学术中相似的文章
[Yan, Chen]的文章
[Huang, Li]的文章
[Liu, Hong-Chun]的文章
必应学术
必应学术中相似的文章
[Yan, Chen]的文章
[Huang, Li]的文章
[Liu, Hong-Chun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。