Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera
Liang, Cheng-Qin1,2,3; Luo, Rong-Hua4; Yan, Ju-Ming1; Li, Yan1; Li, Xiao-Nian1; Shi, Yi-Ming1,3; Shang, Shan-Zhai1,3; Gao, Zhong-Hua1,3; Yang, Liu-Meng4; Zheng, Yong-Tang4; Xiao, Wei-Lie1; Zhang, Hong-Bin2; Sun, Han-Dong1
2014-02-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号37期号:2页码:168-174
摘要Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 mu g ml(-1) and therapeutic index value of 117.12.
关键词Schisandra Sphenanthera Triterpenoid Cytotoxicity Anti-hiv-1
资助信息Chinese Academy of Sciences [KSCX2-EW-Q-10]; NSFC [81102483, 81001462, 30830115]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]; Key Scientific and Technological Program of China [2012ZX10001-006]; project of recruited top talent of sciences and technology of Yunnan Province [2009C1120]; Natural Science Foundation of Yunnan Province [2012FB178]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s12272-013-0133-3
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000330958500002
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17929
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650201, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
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Liang, Cheng-Qin,Luo, Rong-Hua,Yan, Ju-Ming,et al. Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera[J]. ARCHIVES OF PHARMACAL RESEARCH,2014,37(2):168-174.
APA Liang, Cheng-Qin.,Luo, Rong-Hua.,Yan, Ju-Ming.,Li, Yan.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2014).Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera.ARCHIVES OF PHARMACAL RESEARCH,37(2),168-174.
MLA Liang, Cheng-Qin,et al."Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera".ARCHIVES OF PHARMACAL RESEARCH 37.2(2014):168-174.
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