Identification of two novel inhibitors of mTOR signaling pathway based on high content screening
Yan, Juming1,2; Zhou, Hongyu1; Kong, Lingmei1,2; Zhang, Jing1,2; Zhao, Qinshi1; Li, Yan1
2013-10-01
发表期刊CANCER CHEMOTHERAPY AND PHARMACOLOGY
ISSN0344-5704
卷号72期号:4页码:799-808
摘要Mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation and survival. Dysregulation of mTOR signaling pathway is closely involved in cancer development and chemotherapy resistance. Inhibitors of mTOR signaling pathway have been demonstrated to be attractive therapeutics for cancer therapy. In the present study, we aim to discover novel mTOR signaling pathway inhibitors from a natural compound library.
关键词Mtor Signaling Inhibitor High Content Screening Cancer Apoptosis
资助信息hundreds of talents program; west light foundation of the Chinese Academy of Sciences; Major State Basic Research Development Program of China [2009CB522300]; NSFC [81173076]; project of recruited top talent of science and technology of Yunnan Province [2009C1120]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17289
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yan, Juming,Zhou, Hongyu,Kong, Lingmei,et al. Identification of two novel inhibitors of mTOR signaling pathway based on high content screening[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2013,72(4):799-808.
APA Yan, Juming,Zhou, Hongyu,Kong, Lingmei,Zhang, Jing,Zhao, Qinshi,&Li, Yan.(2013).Identification of two novel inhibitors of mTOR signaling pathway based on high content screening.CANCER CHEMOTHERAPY AND PHARMACOLOGY,72(4),799-808.
MLA Yan, Juming,et al."Identification of two novel inhibitors of mTOR signaling pathway based on high content screening".CANCER CHEMOTHERAPY AND PHARMACOLOGY 72.4(2013):799-808.
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