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题名: Two immunosuppressive compounds from the mushroom Rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation
作者: Li, Long-Fei1, 2; Chan, Ben Chung-Lap1, 2; Yue, Grace Gar-Lee1, 2; Lau, Clara Bik-San1, 2; Han, Quan-Bin4; Leung, Ping-Chung1, 2; Liu, Ji-Kai5; Fung, Kwok-Pui1, 2, 3
刊名: PHYTOMEDICINE
关键词: Pistillarin ; 1-ribofuranosyl-s-triazin-2(1H)-one ; Rubinoboletus ballouii ; bioassay-guided fractionation ; peripheral blood mononuclear cells (PBMCs)
英文摘要: Rubinoboletus ballouii is an edible mushroom wildly grown in Yunnan province, China. Up till now, little was known about the chemical and biological properties of this mushroom. The aim of this study was to investigate the immunomodulatory effects of the ethanolic extract of Rubinoboletus ballouii and its fractions on human peripheral blood mononuclear cells (PBMCs) using bioactivity-guided fractionation. The crude extract of the fruiting bodies of RB was fractionated by high-speed counter current chromatography (HSCCC). Twelve fractions were obtained and the third fraction (Fraction C) exerted the most potent anti-inflammatory activities in mitogen-activated PBMCs. Further fractionation of fraction C led to the isolation of two single compounds which were elucidated as 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin, respectively. The results showed that both 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin exhibited significant immunosuppressive effects on phytohemagglutinin (PHA)-stimulated human PBMCs by inhibiting [methyl-H-3]-thymidine uptake and inflammatory cytokines productions such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma and IL-1 beta. Besides, 1-ribofuranosyl-s-triazin-2(1H)-one was-firstly-found in-natural-resources, and pistillarin was also-isolated-from-the-family Boletaceae for the first time. They exhibited great potential in developing as anti-inflammatory reagents. (C) 2013 Elsevier GmbH. All rights reserved.
出版日期: 2013-10-15
卷号: 20, 期号:13, 页码:1196-1202
语种: 英语
ISSN号: 0944-7113
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17277
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

Recommended Citation:
Li, Long-Fei;Chan, Ben Chung-Lap;Yue, Grace Gar-Lee;Lau, Clara Bik-San;Han, Quan-Bin;Leung, Ping-Chung;Liu, Ji-Kai;Fung, Kwok-Pui.Two immunosuppressive compounds from the mushroom Rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation,PHYTOMEDICINE,2013,20(13):1196-1202
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