Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana
Yang, Guang-Yu1,4; Wang, Rui-Rui2,3; Gao, Zhong-Hua1; Li, Yin-Ke1,5; Yang, Liu-Meng2,3; Li, Xiao-Nian1; Shang, Shan-Zhai1; Zheng, Yong-Tang2,3; Xiao, Wei-Lie1; Sun, Han-Dong1
2013-04-01
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号8期号:4页码:467-470
摘要Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 mu g/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.
关键词Schisandra Wilsoniana Lignans Anti-hiv-1 Activities Antitumor Activities
资助信息CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]; Natural Science Foundation of Yunnan Province [2012FB178]; NSFC [20802082, 30830115]; 973 programs [2009CB522300, 2009CB940900]; Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Key Scientific and Technological Projects of China [2009ZX09501-029]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16471
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan Province, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan Province, Peoples R China
4.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China
5.Yunnan Nationalities Univ, Sch Chem & Biotechnol, Kunming 650031, Yunnan, Peoples R China
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Yang, Guang-Yu,Wang, Rui-Rui,Gao, Zhong-Hua,et al. Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana[J]. NATURAL PRODUCT COMMUNICATIONS,2013,8(4):467-470.
APA Yang, Guang-Yu.,Wang, Rui-Rui.,Gao, Zhong-Hua.,Li, Yin-Ke.,Yang, Liu-Meng.,...&Sun, Han-Dong.(2013).Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana.NATURAL PRODUCT COMMUNICATIONS,8(4),467-470.
MLA Yang, Guang-Yu,et al."Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana".NATURAL PRODUCT COMMUNICATIONS 8.4(2013):467-470.
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