Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea
Liang, Cheng-Qin1,3,4; Shi, Yi-Ming1,3; Luo, Rong-Hua2,3; Li, Xing-Yao1,3; Gao, Zhong-Hua1,3; Li, Xiao-Nian1; Yang, Liu-Meng2; Shang, Shan-Zhai1,3; Li, Yan1; Zheng, Yong-Tang2; Zhang, Hong-Bin4; Xiao, Wei-Lie1; Sun, Han-Dong1
2012-12-21
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号14期号:24页码:6362-6365
摘要A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively.
关键词Lancifodilactone-g Stereocontrolled Synthesis Schisandra-chinensis Ring Nortriterpenoids Roots Route Core
资助信息NSFC [20802082, 30830115, 81102483]; CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]; 973 programs [2009CB522300, 2009CB940900]; Natural Science Foundation of Yunnan Province [2012FB178]; project of recruited top talent of sciences and technology of Yunnan Province [2009C1120]; Key Scientific and Technological Projects of China [2009ZX09501-029, 2012ZX10001-006]
学科领域Chemistry, Organic
DOI10.1021/ol303168y
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000312564500062
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15954
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
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GB/T 7714
Liang, Cheng-Qin,Shi, Yi-Ming,Luo, Rong-Hua,et al. Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea[J]. ORGANIC LETTERS,2012,14(24):6362-6365.
APA Liang, Cheng-Qin.,Shi, Yi-Ming.,Luo, Rong-Hua.,Li, Xing-Yao.,Gao, Zhong-Hua.,...&Sun, Han-Dong.(2012).Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea.ORGANIC LETTERS,14(24),6362-6365.
MLA Liang, Cheng-Qin,et al."Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea".ORGANIC LETTERS 14.24(2012):6362-6365.
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