Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis

doi:10.1016/j.steroids.2012.07.007

	Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis
	Qin, Xu-Jie1,2 ; Sun, Dong-Jie 3; Ni, Wei 1; Chen, Chang-Xiang1 ; Hua, Yan 2; He, Li 3; Liu, Hai-Yang1
通讯作者	Liu, HY (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,haiyangliu@mail.kib.ac.cn
	2012-10-01
发表期刊	STEROIDS
ISSN	0039-128X
卷号	77 期号:12 页码:1242-1248
摘要	Rhizoma Paridis, the root of Paris polyphylla var. yunnanensis (Trilliaceae), is a Chinese traditional medicine, which resources become less and less. However, the aerial parts of this herb, which can regenerate every year, were discarded. In order to expand the resources, detailed chemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis led to isolation of one sapogenin and 24 steroidal saponins (1-25). including 6 new glycosides, named chonglouosides SL-1-SL-6 (1-6). Their structures were elucidated on the basis of detailed analyses of their 1D and 2D NMR spectra and acid hydrolysis. Among them, compounds 3 and 4 are the first 23,27-dihydroxydiosgenin saponin having a sugar chain attached to C-23 or C-27, while compound 6 is the first 27-hydroxyruscogenin glycoside bearing 1, 27-di-O-sugar chains. The known compounds 10, 12, 14, 19, 20, 22, and 25 were isolated from the genus Paris for the first time. Antimicrobial testing activities of the selected compounds showed that compound 2, 3, 6, 8, 9, 11, 13, 17, 18, 21, and 24 were active against Propionibacterium acnes with MIC values of 62.5, 62.5, 3.9, 16.5, 17.2, 7.8, 39.0, 17.2, 31.3, 62.5, and 31.3 mu g/ml, respectively. (c) 2012 Elsevier Inc. All rights reserved.
关键词	Paris Polyphylla Var. Yunnanensis Trililiaceae Steroidal Saponins Chonglouosides Sl-1-sl-6
学科领域	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI	10.1016/j.steroids.2012.07.007
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000310480800009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/15950
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.SW Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China 3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Qin, Xu-Jie,Sun, Dong-Jie,Ni, Wei,et al. Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis[J]. STEROIDS,2012,77(12):1242-1248.
APA	Qin, Xu-Jie.,Sun, Dong-Jie.,Ni, Wei.,Chen, Chang-Xiang.,Hua, Yan.,...&Liu, Hai-Yang.(2012).Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis.STEROIDS,77(12),1242-1248.
MLA	Qin, Xu-Jie,et al."Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis".STEROIDS 77.12(2012):1242-1248.

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