Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis
Qin, Xu-Jie1,2; Sun, Dong-Jie3; Ni, Wei1; Chen, Chang-Xiang1; Hua, Yan2; He, Li3; Liu, Hai-Yang1
Corresponding AuthorLiu, HY (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China.,haiyangliu@mail.kib.ac.cn
2012-10-01
Source PublicationSTEROIDS
ISSN0039-128X
Volume77Issue:12Pages:1242-1248
AbstractRhizoma Paridis, the root of Paris polyphylla var. yunnanensis (Trilliaceae), is a Chinese traditional medicine, which resources become less and less. However, the aerial parts of this herb, which can regenerate every year, were discarded. In order to expand the resources, detailed chemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis led to isolation of one sapogenin and 24 steroidal saponins (1-25). including 6 new glycosides, named chonglouosides SL-1-SL-6 (1-6). Their structures were elucidated on the basis of detailed analyses of their 1D and 2D NMR spectra and acid hydrolysis. Among them, compounds 3 and 4 are the first 23,27-dihydroxydiosgenin saponin having a sugar chain attached to C-23 or C-27, while compound 6 is the first 27-hydroxyruscogenin glycoside bearing 1, 27-di-O-sugar chains. The known compounds 10, 12, 14, 19, 20, 22, and 25 were isolated from the genus Paris for the first time. Antimicrobial testing activities of the selected compounds showed that compound 2, 3, 6, 8, 9, 11, 13, 17, 18, 21, and 24 were active against Propionibacterium acnes with MIC values of 62.5, 62.5, 3.9, 16.5, 17.2, 7.8, 39.0, 17.2, 31.3, 62.5, and 31.3 mu g/ml, respectively. (c) 2012 Elsevier Inc. All rights reserved.
KeywordParis Polyphylla Var. Yunnanensis Trililiaceae Steroidal Saponins Chonglouosides Sl-1-sl-6
Subject AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI10.1016/j.steroids.2012.07.007
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000310480800009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15950
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.SW Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
Recommended Citation
GB/T 7714
Qin, Xu-Jie,Sun, Dong-Jie,Ni, Wei,et al. Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis[J]. STEROIDS,2012,77(12):1242-1248.
APA Qin, Xu-Jie.,Sun, Dong-Jie.,Ni, Wei.,Chen, Chang-Xiang.,Hua, Yan.,...&Liu, Hai-Yang.(2012).Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis.STEROIDS,77(12),1242-1248.
MLA Qin, Xu-Jie,et al."Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis".STEROIDS 77.12(2012):1242-1248.
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