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题名: Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis
作者: Qin, Xu-Jie1, 2; Sun, Dong-Jie3; Ni, Wei1; Chen, Chang-Xiang1; Hua, Yan2; He, Li3; null(刘海洋)1
刊名: STEROIDS
关键词: Paris polyphylla var. yunnanensis ; Trililiaceae ; Steroidal saponins ; Chonglouosides SL-1-SL-6
英文摘要: Rhizoma Paridis, the root of Paris polyphylla var. yunnanensis (Trilliaceae), is a Chinese traditional medicine, which resources become less and less. However, the aerial parts of this herb, which can regenerate every year, were discarded. In order to expand the resources, detailed chemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis led to isolation of one sapogenin and 24 steroidal saponins (1-25). including 6 new glycosides, named chonglouosides SL-1-SL-6 (1-6). Their structures were elucidated on the basis of detailed analyses of their 1D and 2D NMR spectra and acid hydrolysis. Among them, compounds 3 and 4 are the first 23,27-dihydroxydiosgenin saponin having a sugar chain attached to C-23 or C-27, while compound 6 is the first 27-hydroxyruscogenin glycoside bearing 1, 27-di-O-sugar chains. The known compounds 10, 12, 14, 19, 20, 22, and 25 were isolated from the genus Paris for the first time. Antimicrobial testing activities of the selected compounds showed that compound 2, 3, 6, 8, 9, 11, 13, 17, 18, 21, and 24 were active against Propionibacterium acnes with MIC values of 62.5, 62.5, 3.9, 16.5, 17.2, 7.8, 39.0, 17.2, 31.3, 62.5, and 31.3 mu g/ml, respectively. (c) 2012 Elsevier Inc. All rights reserved.
出版日期: 2012-10-01
卷号: 77, 期号:12, 页码:1242-1248
DOI标识: 10.1016/j.steroids.2012.07.007
语种: 英语
ISSN号: 0039-128X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/15950
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.SW Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China

Recommended Citation:
Qin, Xu-Jie; Sun, Dong-Jie; Ni, Wei; Chen, Chang-Xiang; Hua, Yan; He, Li; Liu, Hai-Yang.Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis,STEROIDS,2012,77(12):1242-1248
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