Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum
Cao, Mingming1,2; Zhang, Yu1; He, Hongping1; Li, Shifei1,2; Huang, Shendian1,2; Chen, Duozhi1,2; Tang, Guihua1,2; Li, Shunlin1; Di, Yingtong1; Hao, Xiaojiang1
2012-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:6页码:1076-1082
摘要Ten new yuzurine-type Daphniphyllum alkaloids, daphmacromines A-J (1-10), along with seven known alkaloids were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The pesticidal and cytotoxic activities of the isolated alkaloids were evaluated in vitro against brine shrimp (Artemia sauna) and five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), respectively. This study also suggested structural revisions of oxodaphnigracine, oxodaphnigraciline, and epioxodaphnigraciline.
关键词Skeleton Cascade Humile Assay Miq
资助信息National Natural Science Foundation of China [30830114, 31100259]; National Basic Research Program of China (973 Program) [2009CB522303, 2009CB940900]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
DOI10.1021/np200960z
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000305503500011
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/15762
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Cao, Mingming,Zhang, Yu,He, Hongping,et al. Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1076-1082.
APA Cao, Mingming.,Zhang, Yu.,He, Hongping.,Li, Shifei.,Huang, Shendian.,...&Hao, Xiaojiang.(2012).Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum.JOURNAL OF NATURAL PRODUCTS,75(6),1076-1082.
MLA Cao, Mingming,et al."Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1076-1082.
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