Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi
Wu, Xing-De2,3; He, Juan2; Shen, Yu4; Dong, Liao-Bin2,3; Pan, Zheng-Hong2; Xu, Gang2; Gong, Xun2; Song, Liu-Dong1; Leng, Ying4; Li, Yan2; Peng, Li-Yan2; Zhao, Qin-Shi2
2012-02-15
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号53期号:7页码:800-803
摘要Three novel triterpenoids, pseudoferic acids A and B (1 and 2) possessed a unique 16,24-cyclo-26-norlanostane skeleton, and pseudoferic acid C (3) featured a cis-fused D/E-ring system, were isolated from the root bark of Pseudolarix kaempferi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 exhibited weak inhibitory activities against 110-HSD1 (110-hydroxysteroid dehydrogenase 1) with IC50 values of 0.44 (mouse 11 beta-HSD1) and 0.75 mu M (human 11 beta-HSD1), respectively. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Pseudolarix Kaempferi Triterpenoids 11 Beta-hsd1 Inhibitory Activity
资助信息National Basic Research Program of China (973 Program)[2009CB522303, 2011CB915503]; National Natural Science Foundation of China[90813004, U0932602]; Chinese Academy of sciences[2009311211011, 2009312311024]; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ05]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10505
专题资源植物与生物技术所级重点实验室
作者单位1.Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
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Wu, Xing-De,He, Juan,Shen, Yu,et al. Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi[J]. TETRAHEDRON LETTERS,2012,53(7):800-803.
APA Wu, Xing-De.,He, Juan.,Shen, Yu.,Dong, Liao-Bin.,Pan, Zheng-Hong.,...&Zhao, Qin-Shi.(2012).Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi.TETRAHEDRON LETTERS,53(7),800-803.
MLA Wu, Xing-De,et al."Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi".TETRAHEDRON LETTERS 53.7(2012):800-803.
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