| Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi | |
Wu, Xing-De2,3; He, Juan2; Shen, Yu4; Dong, Liao-Bin2,3; Pan, Zheng-Hong2; Xu, Gang2 ; Gong, Xun2; Song, Liu-Dong1; Leng, Ying4; Li, Yan2; Peng, Li-Yan2; Zhao, Qin-Shi2
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| 通讯作者 | Song, LD (reprint author), Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China, ynsld@126.com ; qinshizhao@mail.kib.ac.cn |
| 2012-02-15 | |
| 发表期刊 | TETRAHEDRON LETTERS
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| ISSN | 0040-4039 |
| 卷号 | 53期号:7页码:800-803 |
| 摘要 | Three novel triterpenoids, pseudoferic acids A and B (1 and 2) possessed a unique 16,24-cyclo-26-norlanostane skeleton, and pseudoferic acid C (3) featured a cis-fused D/E-ring system, were isolated from the root bark of Pseudolarix kaempferi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 exhibited weak inhibitory activities against 110-HSD1 (110-hydroxysteroid dehydrogenase 1) with IC50 values of 0.44 (mouse 11 beta-HSD1) and 0.75 mu M (human 11 beta-HSD1), respectively. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Pseudolarix Kaempferi Triterpenoids 11 Beta-hsd1 Inhibitory Activity |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1016/j.tetlet.2011.12.004 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000300518900019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/10505 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Kunming Med Univ, Coll Pharmacol, Kunming 650031, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xing-De,He, Juan,Shen, Yu,et al. Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi[J]. TETRAHEDRON LETTERS,2012,53(7):800-803. |
| APA | Wu, Xing-De.,He, Juan.,Shen, Yu.,Dong, Liao-Bin.,Pan, Zheng-Hong.,...&Zhao, Qin-Shi.(2012).Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi.TETRAHEDRON LETTERS,53(7),800-803. |
| MLA | Wu, Xing-De,et al."Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi".TETRAHEDRON LETTERS 53.7(2012):800-803. |
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