Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii
Xu, Gang; Yang, Xing-Wei; Wu, Chun-Yan; Li, Xiao-Nian; Su, Jia; Deng, Xu; Li, Yan; Qin, Hong-Bo; Yang, Li-Xin; Zhao, Qin-Shi
2012
发表期刊CHEMICAL COMMUNICATIONS
ISSN1359-7345
卷号48期号:37页码:4438-4440
摘要Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels-Alder cycloaddition, was isolated from the roots of Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis of NMR spectra and crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC50 0.69-2.35 mu M).
关键词Ligularia Species Eremophilanes Oplopanes Phenylpropenoids Dna Introgression Chemotaxonomy Sinapyl Alcohol Derivatives Eremophilane-type Sesquiterpenoids Polyacetylenic Compounds Southwestern Sichuan Medicinal-plants Constituents Diversity Nelumbifolia Senecioneae Veitchiana
资助信息foundation from NSFC[20702054]; CAS[KSCX2-EW-J-24]; Shanghai Landscaping Administration Bureau[G102404]; Young Academic and Technical Leader Raising Foundation of Yunnan Province[2009CI073]
学科领域Chemistry, Multidisciplinary
DOI10.1039/c2cc30405h
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000302559100013
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/10349
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Xu, Gang,Yang, Xing-Wei,Wu, Chun-Yan,et al. Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii[J]. CHEMICAL COMMUNICATIONS,2012,48(37):4438-4440.
APA Xu, Gang.,Yang, Xing-Wei.,Wu, Chun-Yan.,Li, Xiao-Nian.,Su, Jia.,...&Zhao, Qin-Shi.(2012).Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii.CHEMICAL COMMUNICATIONS,48(37),4438-4440.
MLA Xu, Gang,et al."Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii".CHEMICAL COMMUNICATIONS 48.37(2012):4438-4440.
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