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AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21 期刊论文
CELL CYCLE, 2016, 卷号: 15, 期号: 13, 页码: 1733-1741
作者:  Gongpan, Pianchou;  Lu, Yanting;  Wang, Fang;  Xu, Yuhui;  Xiong, Wenyong
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As160/tbc1d4  Cell Cycle  Cell Proliferation  G1/s  P21  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 卷号: 670, 期号: 2-3, 页码: 427-434
作者:  Luo, Xiang-jian;  Li, Wei;  Yang, Li-fang;  Yu, Xin-fang;  Xiao, Lan-bo;  Tang, Min;  Dong, Xin;  Deng, Qi-pan;  Bode, Ann M.;  Liu, Ji-kai;  Cao, Ya
Adobe PDF(1137Kb)  |  收藏  |  浏览/下载：517/161  |  提交时间：2012/04/10
Grifolin  Dapk1  Cell Cycle  P21  Erk1/2  Npc  Mushroom