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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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耿长安 [3]
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GST, p < 0.01). At the regional level, Chinese and Japanese L. hodgsonii had a similar estimate of genetic diversity (China: Hd = 0.847, HT = 0.869; Japan: Hd = 0.766, HT = 0.867). Populations from China and Japan possess unique sets of haplotypes, and no haplotypes were shared between the regions. Furthermore, both the phyloegenetic and network analyses recovered the haplotypes of China and Japan as two distinct clades. Thus, we suggested the disjunct distribution of L. hodgsonii in China and Japan may present the climatic vicariant relicts of the ancient widely distributed populations. After divergence, this species within each region experienced independent evolutionary process. In China, L. hodgsonii was distributed around the Sichuan Basin. This distribution range can be divided into five regions. They were Jiajin Mountain region, E’mei Mountain region, Yunnan-Guizhou Plateau region, Wushan-Wuling Mountain region and Qinling Mountain region. Twelve haplotypes were indentified within these regions. Each region had its own specific haplotypes, which had different ancestry in the network. We deduced that Chinese L. hodgsonii might survive the LGM in multiple isolated refugia around the Sichuan Basin. In Japan, L. hodgsonii was disjunctively distributed in northern Honshu and Hokkaido. Seven haplotypes were identified within this region. However, the genetic diversity in Honshu (Hd = 0.821) was much higher than that in Hokkaido (Hd = 0.513). And all haplotypes in Hokkaido were derived from Honshu. This haplotype distribution suggested that the northern Honshu could have served as refuge in Japan. Nested clade analysis (NCA) indicated multiple forces including the vicariance and long-distance dispersal affected the disjunctive distribution among populations of L. hodgsonii in Japan.2. The phylogeography of L. tongolensis，Ligularia tongolensis was distributed along the Jinshajiang watershed, Yalongjiang watershed and Wumeng Mountain. In order to deduce the demographic history of this species, we sequenced two chloroplast DNA (cpDNA) intergenic spacers (trnQ-5’rps16, trnL-rpl32) in 140 individuals from 14 populations of three groups (Jinshajiang vs. Yalongjiang vs. Wumeng) within this species range. High levels of haplotype diversity (Hd = 0.814) and total genetic diversity (HT = 0.862) were detected at the species level, based on a total oftwelve haplotypes identified. However, the intrapopulation diversity (HS = 0.349) was low, which led to the high levels of genetic divergence (GST = 0.595, NST = 0.614, FST = 0.597). In consideration of the speciation of L. tongolensis resulting from the uplifts of the Qinghai-Tibetan Plateau (QTP), we thought the present genetic structure of L. tongolensis was shaped by the fragmentation of ancestral populations during the courses of QTP uplifts. This was further supported by the absence of IBD tests (r = –0.291, p = 0.964), which suggest that the differentiation had not occurred in accordance with the isolation by distance model. The genetic differentiation in L. tongolensis appears to be associated with historical events. Meanwhile, H2 and H5, the dominant haplotypes that located on internal nodes and deviated from extinct ancestral haplotype in the network, were detected to be shared between Jinshajiang and Yalongjiang groups. We deduced that ancestral populations of this species might have had a continuous distribution range, which was then fragmented and isolated by the following tectonic events. Finally, the ancestral polymorphism, H2 and H5, were randomly allocated in Jinshajiang watershed and Yalongjiang watershed. Meanwhile, H5 was the dominant haplotype in Jinshajiang watershed; H7 was the domiant haplotype in Yalongjiang watershed and Wumeng Mountain. This haplotype distribution pattern indicated that each group might have served as a refuge for L. tongolensis during the Quaternary Glaciation. Postglacial demographic expansion was supported by unimodal mismatch distribution and star-like phylogenies, with expansion ages of 274 ka B. P. for this 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thesis includes four chapters: Chapters 1 and 2 cover bioactive constituents of two traditional Chininese medicines of Ding-Zhi-Yuan prescription: Acorus tatarinowii Schott. and Poria cum Radix Pini. Chapter 3 introduces chemical components of flavonoids from the gum of Cerasus conradinae. In the last chapter, the research progress of Acorus was reviewed. As a result, 60 compounds were isolated from these plants, and eight of them were identified as new ones. Their structures were established on the basis of spectroscopic data. The types of these compounds include phenylpropanoids, lignans, flavonoids, sesquiterpenoids, alkaloids, and steroids.Chapter 1 introduced the chemical constitutents of Acorus tatarinowii Schott. Acorus tatarinowii Schott is a famous traditional Chinese medicine possessing anticonvulsive,spasmolytic, and neuroprotective effects. To study its pharmacological mechanism, 47 compounds, including 7 new ones, were isolated from this herb. AlphaScreen cAMP assay showed that six phenylpropanoids significantly increased cAMP level at the concentration of 50 µM. Two novel spiro-alkaloids inhibited high glucose-induced ROS production in mesangial cells. Besides, their anti-oxidant activities were dose-dependent and reached to the maximum at 10 μM and 50 μM, respectively.Chapter 2 introduced the chemical constitutents of Poria cum Radix Pin. Poria cum Radix Pini is the xylem of Poria cocos (Schw.) Wolf. As a traditional Chinese medicine, it has the effects for treatment of palpitation, forgettery, insomnia and other diseases. Chemical investigation about it resulted in 9 compounds and 1 compound was elucidated to be new. Chater 3 introduced the chemical constituents of flavonoids from the gum of Cerasus conradina.ere isolated from the gum ofCerasus conradinae. The fruits of Cerasus conradina were used to deal with heart failure, beriberi and edema. Because of frostibe, pest, and mechanical damage, Cerasus conradin excrete lots of gum in winter. To investigate the chemical constituents and the chemical defence function of the gum, 4 flavonoids with different structure types w. Chapter 4 reviewed the progress of the studies on chemistry and bioactivity of chemical constituents from Acorus","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E5%2580%258D%25E5%258D%258A%25E8%2590%259C&order=desc&&fq=dc.project.title_filter%3AThe%5C+thesis%5C+includes%5C+four%5C+chapters%5C%3A%5C+Chapters%5C+1%5C+and%5C+2%5C+cover%5C+bioactive%5C+constituents%5C+of%5C+two%5C+traditional%5C+Chininese%5C+medicines%5C+of%5C+Ding%5C-Zhi%5C-Yuan%5C+prescription%5C%3A%5C+Acorus%5C+tatarinowii%5C+Schott.%5C+and%5C+Poria%5C+cum%5C+Radix%5C+Pini.%5C+Chapter%5C+3%5C+introduces%5C+chemical%5C+components%5C+of%5C+flavonoids%5C+from%5C+the%5C+gum%5C+of%5C+Cerasus%5C+conradinae.%5C+In%5C+the%5C+last%5C+chapter%2C%5C+the%5C+research%5C+progress%5C+of%5C+Acorus%5C+was%5C+reviewed.%5C+As%5C+a%5C+result%2C%5C+60%5C+compounds%5C+were%5C+isolated%5C+from%5C+these%5C+plants%2C%5C+and%5C+eight%5C+of%5C+them%5C+were%5C+identified%5C+as%5C+new%5C+ones.%5C+Their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+spectroscopic%5C+data.%5C+The%5C+types%5C+of%5C+these%5C+compounds%5C+include%5C+phenylpropanoids%2C%5C+lignans%2C%5C+flavonoids%2C%5C+sesquiterpenoids%2C%5C+alkaloids%2C%5C+and%5C+steroids.Chapter%5C+1%5C+introduced%5C+the%5C+chemical%5C+constitutents%5C+of%5C+Acorus%5C+tatarinowii%5C+Schott.%5C+Acorus%5C+tatarinowii%5C+Schott%5C+is%5C+a%5C+famous%5C+traditional%5C+Chinese%5C+medicine%5C+possessing%5C+anticonvulsive%2Cspasmolytic%2C%5C+and%5C+neuroprotective%5C+effects.%5C+To%5C+study%5C+its%5C+pharmacological%5C+mechanism%2C%5C+47%5C+compounds%2C%5C+including%5C+7%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+this%5C+herb.%5C+AlphaScreen%5C+cAMP%5C+assay%5C+showed%5C+that%5C+six%5C+phenylpropanoids%5C+significantly%5C+increased%5C+cAMP%5C+level%5C+at%5C+the%5C+concentration%5C+of%5C+50%5C+%C2%B5M.%5C+Two%5C+novel%5C+spiro%5C-alkaloids%5C+inhibited%5C+high%5C+glucose%5C-induced%5C+ROS%5C+production%5C+in%5C+mesangial%5C+cells.%5C+Besides%2C%5C+their%5C+anti%5C-oxidant%5C+activities%5C+were%5C+dose%5C-dependent%5C+and%5C+reached%5C+to%5C+the%5C+maximum%5C+at%5C+10%5C+%CE%BCM%5C+and%5C+50%5C+%CE%BCM%2C%5C+respectively.Chapter%5C+2%5C+introduced%5C+the%5C+chemical%5C+constitutents%5C+of%5C+Poria%5C+cum%5C+Radix%5C+Pin.%5C+Poria%5C+cum%5C+Radix%5C+Pini%5C+is%5C+the%5C+xylem%5C+of%5C+Poria%5C+cocos%5C+%5C%28Schw.%5C%29%5C+Wolf.%5C+As%5C+a%5C+traditional%5C+Chinese%5C+medicine%2C%5C+it%5C+has%5C+the%5C+effects%5C+for%5C+treatment%5C+of%5C+palpitation%2C%5C+forgettery%2C%5C+insomnia%5C+and%5C+other%5C+diseases.%5C+Chemical%5C+investigation%5C+about%5C+it%5C+resulted%5C+in%5C+9%5C+compounds%5C+and%5C+1%5C+compound%5C+was%5C+elucidated%5C+to%5C+be%5C+new.%5C+Chater%5C+3%5C+introduced%5C+the%5C+chemical%5C+constituents%5C+of%5C+flavonoids%5C+from%5C+the%5C+gum%5C+of%5C+Cerasus%5C+conradina.ere%5C+isolated%5C+from%5C+the%5C+gum%5C+ofCerasus%5C+conradinae.%5C+The%5C+fruits%5C+of%5C+Cerasus%5C+conradina%5C+were%5C+used%5C+to%5C+deal%5C+with%5C+heart%5C+failure%2C%5C+beriberi%5C+and%5C+edema.%5C+Because%5C+of%5C+frostibe%2C%5C+pest%2C%5C+and%5C+mechanical%5C+damage%2C%5C+Cerasus%5C+conradin%5C+excrete%5C+lots%5C+of%5C+gum%5C+in%5C+winter.%5C+To%5C+investigate%5C+the%5C+chemical%5C+constituents%5C+and%5C+the%5C+chemical%5C+defence%5C+function%5C+of%5C+the%5C+gum%2C%5C+4%5C+flavonoids%5C+with%5C+different%5C+structure%5C+types%5C+w.%5C+Chapter%5C+4%5C+reviewed%5C+the%5C+progress%5C+of%5C+the%5C+studies%5C+on%5C+chemistry%5C+and%5C+bioactivity%5C+of%5C+chemical%5C+constituents%5C+from%5C+Acorus"},{"jsname":"The thesis includes three chapters, which introduce chemical constituents of three plants, Dysoxylum laxiracemosum, Dysoxylum hainanense and Allophylus longipes. Eighty compounds, 14 of which are new, were isolated from above plants. New compounds include 8 new N-containing tirucallanes, 1 new tirucallane,4 nordammaranes and 1 ent-pimarane. Chapter 1. Studies on Chemical Constituents of Dysoxylum laxiracemosum, Plants of the Meliaceae family are rich sources of structurally diverse and biologically significant limonoids. The chemical constituents of Dysoxylum laxiracemosum of Meliaceae have not been investigated up to date. In the present study on the chemical constituents of this species, 8 new N-containing tirucallanes and 1 new tirucallane, together with 18 known compounds were obtained by chromatographic methods. Those structures were determined by spectral methods.Chapter 2. Studies on Chemical Constituents from Dysoxylum hainanense, Different types of limonoids, tirucallanes, apo-tirucallols, dammaranes, and ent-pimaranes were isolated from Dysoxylum hainanense collected from Yunnan province in our previous studies. However, two novel rearranged oleanane-type triterpenes and six ring A modified novel triterpenoids were reported from D. hainanense collected from Hainan province recently, which prompt us to re-investigate chemical constitutents of Dysoxylum hainanense in Yunnan. As a result, neither rearranged oleananes nor ring A modified triterpenoids were found in this experiment, but 5 new compounds, including 4 nordammaranes and 1 ent-pimarane, along with 21 known compounds, were obtained by chromatographic methods. Those structures were determined by spectral methods.Chapter 3. Studies on Chemical Constituents from Allophylus longipes, The genus Allophylus comprises about 255 species, 6 of which are distributed in China. 3 species of this genus have been found in Yunnan province. Allophylus longipes has been historically used as a folk remedy in ‘Dai’ ethnopharmacy for treatments of cold and inflammation in Yunnan province, China. But the chemical constituents of Allophylus longipes have not been investigated up to now. In the present study on the chemical constituents of this species, 27 compounds were isolated and identified by chromatographic methods. Those structures were determined by spectral methods.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E5%2580%258D%25E5%258D%258A%25E8%2590%259C&order=desc&&fq=dc.project.title_filter%3AThe%5C+thesis%5C+includes%5C+three%5C+chapters%2C%5C+which%5C+introduce%5C+chemical%5C+constituents%5C+of%5C+three%5C+plants%2C%5C+Dysoxylum%5C+laxiracemosum%2C%5C+Dysoxylum%5C+hainanense%5C+and%5C+Allophylus%5C+longipes.%5C+Eighty%5C+compounds%2C%5C+14%5C+of%5C+which%5C+are%5C+new%2C%5C+were%5C+isolated%5C+from%5C+above%5C+plants.%5C+New%5C+compounds%5C+include%5C+8%5C+new%5C+N%5C-containing%5C+tirucallanes%2C%5C+1%5C+new%5C+tirucallane%2C4%5C+nordammaranes%5C+and%5C+1%5C+ent%5C-pimarane.%5C+Chapter%5C+1.%5C+Studies%5C+on%5C+Chemical%5C+Constituents%5C+of%5C+Dysoxylum%5C+laxiracemosum%2C%5C+Plants%5C+of%5C+the%5C+Meliaceae%5C+family%5C+are%5C+rich%5C+sources%5C+of%5C+structurally%5C+diverse%5C+and%5C+biologically%5C+significant%5C+limonoids.%5C+The%5C+chemical%5C+constituents%5C+of%5C+Dysoxylum%5C+laxiracemosum%5C+of%5C+Meliaceae%5C+have%5C+not%5C+been%5C+investigated%5C+up%5C+to%5C+date.%5C+In%5C+the%5C+present%5C+study%5C+on%5C+the%5C+chemical%5C+constituents%5C+of%5C+this%5C+species%2C%5C+8%5C+new%5C+N%5C-containing%5C+tirucallanes%5C+and%5C+1%5C+new%5C+tirucallane%2C%5C+together%5C+with%5C+18%5C+known%5C+compounds%5C+were%5C+obtained%5C+by%5C+chromatographic%5C+methods.%5C+Those%5C+structures%5C+were%5C+determined%5C+by%5C+spectral%5C+methods.Chapter%5C+2.%5C+Studies%5C+on%5C+Chemical%5C+Constituents%5C+from%5C+Dysoxylum%5C+hainanense%2C%5C+Different%5C+types%5C+of%5C+limonoids%2C%5C+tirucallanes%2C%5C+apo%5C-tirucallols%2C%5C+dammaranes%2C%5C+and%5C+ent%5C-pimaranes%5C+were%5C+isolated%5C+from%5C+Dysoxylum%5C+hainanense%5C+collected%5C+from%5C+Yunnan%5C+province%5C+in%5C+our%5C+previous%5C+studies.%5C+However%2C%5C+two%5C+novel%5C+rearranged%5C+oleanane%5C-type%5C+triterpenes%5C+and%5C+six%5C+ring%5C+A%5C+modified%5C+novel%5C+triterpenoids%5C+were%5C+reported%5C+from%5C+D.%5C+hainanense%5C+collected%5C+from%5C+Hainan%5C+province%5C+recently%2C%5C+which%5C+prompt%5C+us%5C+to%5C+re%5C-investigate%5C+chemical%5C+constitutents%5C+of%5C+Dysoxylum%5C+hainanense%5C+in%5C+Yunnan.%5C+As%5C+a%5C+result%2C%5C+neither%5C+rearranged%5C+oleananes%5C+nor%5C+ring%5C+A%5C+modified%C2%A0triterpenoids%5C+were%5C+found%5C+in%5C+this%5C+experiment%2C%5C+but%5C+5%5C+new%5C+compounds%2C%5C+including%5C+4%5C+nordammaranes%5C+and%5C+1%5C+ent%5C-pimarane%2C%5C+along%5C+with%5C+21%5C+known%5C+compounds%2C%5C+were%5C+obtained%5C+by%5C+chromatographic%5C+methods.%5C+Those%5C+structures%5C+were%5C+determined%5C+by%5C+spectral%5C+methods.Chapter%5C+3.%5C+Studies%5C+on%5C+Chemical%5C+Constituents%5C+from%5C+Allophylus%5C+longipes%2C%5C+The%5C+genus%5C+Allophylus%5C+comprises%5C+about%5C+255%5C+species%2C%5C+6%5C+of%5C+which%5C+are%5C+distributed%5C+in%5C+China.%5C+3%5C+species%5C+of%5C+this%5C+genus%5C+have%5C+been%5C+found%5C+in%5C+Yunnan%5C+province.%5C+Allophylus%5C+longipes%5C+has%5C+been%5C+historically%5C+used%5C+as%5C+a%5C+folk%5C+remedy%5C+in%5C+%E2%80%98Dai%E2%80%99%5C+ethnopharmacy%5C+for%5C+treatments%5C+of%5C+cold%5C+and%5C+inflammation%5C+in%5C+Yunnan%5C+province%2C%5C+China.%5C+But%5C+the%5C+chemical%5C+constituents%5C+of%5C+Allophylus%5C+longipes%5C+have%5C+not%5C+been%5C+investigated%5C+up%5C+to%5C+now.%5C+In%5C+the%5C+present%5C+study%5C+on%5C+the%5C+chemical%5C+constituents%5C+of%5C+this%5C+species%2C%5C+27%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%5C+by%5C+chromatographic%5C+methods.%5C+Those%5C+structures%5C+were%5C+determined%5C+by%5C+spectral%5C+methods."},{"jsname":"This dissertation consists of four chapters. First chapter presents the result of investigation on chemical constituents and cytotoxic activities of Isodon rubescens var. rubescens f. lushanensis collected in Luanchuan prefecture of Henan province. Second chapter gives the research result on chemical constituents and cytotoxic activities of I leucophyllus (Dunn)Kudo collected in Shangri-La county, Yunnan province. The third chapter describes the same theme of I. scoparius C. Y. Wu et H. W. Li(Dunn)Kudocollected in Shangri-La county, Yunnan province. Chapter 4 is a review on the research progress of bicyclic and tricyclic diterpenoids in natural products, recently.80 compounds were isolated and identified from the above mentioned plants of the genus Isodon by means of chromatograhy methods and spectroscopic analyses, including 24 new compounds. Structural style of these compounds includes diterpenoids (ent-kaurane, ent-kaurane dimer, ent-abietane, ent-labdane, ent-clerodane), triterpenoids, steroids, flavonoids, and lignans. From ITwo diterpenoid dimmers with unique 16→17'' linkage were isolated and characterized from I leucophyllus for the first time. One ent-kaurane diterpenoids and one ent-clerodane dinorditerpenoid were isolated from Isodon scoparius. Especially, it was a powerful chemical evidence to clarify Isodon scoparius was one original species in the genus Isodon in view of biosynthetic pathway... rubescens var. rubescens f. lushanensis, two novel diterpenoids with unprecedented skeletons (one possessed a broken A ring and another with an expanded B ring) were isolated for the first time. Most diterpenoids were evaluated for their cytotoxic activity against several kinds of human tumor cell lines in vitro. Some of them exhibited significant activities and deserved to be studied thoroughly. With the preservation of bioactive center (α-mythelene cyclopentanone) in the structure, the diterpenoid which possesed a broken A ring still displayed potent cytotoxicity in HL-60 cell line. It could provide a helpful clue for simplifying the chemical structure of diterpenoids with significant cytotoxicity.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E5%2580%258D%25E5%258D%258A%25E8%2590%259C&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+consists%5C+of%5C+four%5C+chapters.%5C+First%5C+chapter%5C+presents%5C+the%5C+result%5C+of%5C+investigation%5C+on%5C+chemical%5C+constituents%5C+and%5C+cytotoxic%5C+activities%5C+of%5C+Isodon%5C+rubescens%5C+var.%5C+rubescens%5C+f.%5C+lushanensis%5C+collected%5C+in%5C+Luanchuan%5C+prefecture%5C+of%5C+Henan%5C+province.%5C+Second%5C+chapter%5C+gives%5C+the%5C+research%5C+result%5C+on%5C+chemical%5C+constituents%5C+and%5C+cytotoxic%5C+activities%5C+of%5C+I%5C+leucophyllus%5C+%5C%28Dunn%5C%29Kudo%5C+collected%5C+in%5C+Shangri%5C-La%5C+county%2C%5C+Yunnan%5C+province.%5C+The%5C+third%5C+chapter%5C+describes%5C+the%5C+same%5C+theme%5C+of%5C+I.%5C+scoparius%5C+C.%5C+Y.%5C+Wu%5C+et%5C+H.%5C+W.%5C+Li%5C%28Dunn%5C%29Kudocollected%5C+in%5C+Shangri%5C-La%5C+county%2C%5C+Yunnan%5C+province.%5C+Chapter%5C+4%5C+is%5C+a%5C+review%5C+on%5C+the%5C+research%5C+progress%5C+of%5C+bicyclic%5C+and%5C+tricyclic%5C+diterpenoids%5C+in%5C+natural%5C+products%2C%5C+recently.80%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+above%5C+mentioned%5C+plants%5C+of%5C+the%5C+genus%5C+Isodon%5C+by%5C+means%5C+of%5C+chromatograhy%5C+methods%5C+and%5C+spectroscopic%5C+analyses%2C%5C+including%5C+24%5C+new%5C+compounds.%5C+Structural%5C+style%5C+of%5C+these%5C+compounds%5C+includes%5C+diterpenoids%5C+%5C%28ent%5C-kaurane%2C%5C+ent%5C-kaurane%5C+dimer%2C%5C+ent%5C-abietane%2C%5C+ent%5C-labdane%2C%5C+ent%5C-clerodane%5C%29%2C%5C+triterpenoids%2C%5C+steroids%2C%5C+flavonoids%2C%5C+and%5C+lignans.%5C+From%5C+ITwo%5C+diterpenoid%5C+dimmers%5C+with%5C+unique%5C+16%E2%86%9217%27%27%5C+linkage%5C+were%5C+isolated%5C+and%5C+characterized%5C+from%5C+I%5C+leucophyllus%5C+for%5C+the%5C+first%5C+time.%5C+One%5C+ent%5C-kaurane%5C+diterpenoids%5C+and%5C+one%5C+ent%5C-clerodane%5C+dinorditerpenoid%5C+were%5C+isolated%5C+from%5C+Isodon%5C+scoparius.%5C+Especially%2C%5C+it%5C+was%5C+a%5C+powerful%5C+chemical%5C+evidence%5C+to%5C+clarify%5C+Isodon%5C+scoparius%5C+was%5C+one%5C+original%5C+species%5C+in%5C+the%5C+genus%5C+Isodon%5C+in%5C+view%5C+of%5C+biosynthetic%5C+pathway...%5C+rubescens%5C+var.%5C+rubescens%5C+f.%5C+lushanensis%2C%5C+two%5C+novel%5C+diterpenoids%5C+with%5C+unprecedented%5C+skeletons%5C+%5C%28one%5C+possessed%5C+a%5C+broken%5C+A%5C+ring%5C+and%5C+another%5C+with%5C+an%5C+expanded%5C+B%5C+ring%5C%29%5C+were%5C+isolated%5C+for%5C+the%5C+first%5C+time.%5C+Most%5C+diterpenoids%5C+were%5C+evaluated%5C+for%5C+their%5C+cytotoxic%5C+activity%5C+against%5C+several%5C+kinds%5C+of%5C+human%5C+tumor%5C+cell%5C+lines%5C+in%5C+vitro.%5C+Some%5C+of%5C+them%5C+exhibited%5C+significant%5C+activities%5C+and%5C+deserved%5C+to%5C+be%5C+studied%5C+thoroughly.%5C+With%5C+the%5C+preservation%5C+of%5C+bioactive%5C+center%5C+%5C%28%CE%B1%5C-mythelene%5C+cyclopentanone%5C%29%5C+in%5C+the%5C+structure%2C%5C+the%5C+diterpenoid%5C+which%5C+possesed%5C+a%5C+broken%5C+A%5C+ring%5C+still%5C+displayed%5C+potent%5C+cytotoxicity%5C+in%5C+HL%5C-60%5C+cell%5C+line.%5C+It%5C+could%5C+provide%5C+a%5C+helpful%5C+clue%5C+for%5C+simplifying%5C+the%5C+chemical%5C+structure%5C+of%5C+diterpenoids%5C+with%5C+significant%5C+cytotoxicity."},{"jsname":"This dissertation is composed of eight chapters. In chapters 1-7, the chemical and bioactive constituents of seven higher fungi, Boreostereum vibrans, Hexagonia speciosa, Panaeolus leucophanes, Gomphus purpuraceus, Sparassis crispa, Craterellus aureus and Hydnum repandum have been investigated. In chapter 8, a review about the chemical and bioactivity of N-containing compounds of macromycetes between 2004 and 2009 was given.100 compounds, including 36 new ones, were isolated from the above mentioned seven species. Their structures were established on the basis of extensive spectroscopic methods in combination with single-crystal X-ray diffraction analysis. The type of the isolated compounds includes sesquiterpenoids, ergostols, isocoumarins, vibralactone derivertives, as well as oxygenated cyclohexanoids.Fourteen compounds were isolated from the culture broth of basidiomycete Boreostereum vibrans (Berk & M.A. Curtis Davydkina & Bondartseva (Aphyllophorales)). Among them, seven new ones were the vibralactone derivatives. 1,5-Secovibralactone and vibralactone C exhibited moderate inhibitory effect against human 11β-HSD1 but did not exhibit inhibition on 11β-HSD2. Vibralactone B, vibralactone D and acetylated vibralactone showed inhibitory activities against both 11β-HSD1 and 11β-HSD2. Twenty new oxygenated cyclohexanoids and a new acetylated aporpinone compounds, together with seven known compounds were isolated from the broth cultures of the basidiomycete Hexagonia speciosa. Their structures were elucidated on the basis of extensive spectroscopic analysis, while the structure of 8 was confirmed by single crystal X-ray diffraction data.Phytochemical study of the culture of Panaeolus leucophanes has resulted in the isolation of thirteen compounds which of eight were isocoumarins, including four new ones. Their structures were elucidated on the basis of extensive spectroscopic analysis. A new alliacane sesquiterpene, together with 5 known compounds, have been isolated from the fruiting bodies of Gomphus purpuraceu. Their structures were elucidated by means of spectroscopic methods (1D and 2D NMR, MS, IR). Five known compounds have been isolated from the culture broth of Sparassis crispa, and five from the fruiting bodies including two new compounds. Their structures were elucidated by means of spectroscopic methods (1D and 2D NMR, MS, IR). A new hydroxyl acetylenic fatty acid, together with ten known compounds have been isolated from the fruiting bodies of Craterellus aureus, and their structures were elucidated by means of spectroscopic methods (1D and 2D NMR, MS, IR). Eleven known compounds have been isolated from the culture broth of Hydnum repandum. Their structures were elucidated by means of spectroscopic methods (1D NMR, MS).In chapter 8, the chemical, biological, and mycological literature dealing with the isolation, structure elucidation, biological activities, and synthesis of nitrogen-containing compounds from the fruiting bodies and the culture broths of macromycetes were reviewed (2004-2009).","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E5%2580%258D%25E5%258D%258A%25E8%2590%259C&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+is%5C+composed%5C+of%5C+eight%5C+chapters.%5C+In%5C+chapters%5C+1%5C-7%2C%5C+the%5C+chemical%5C+and%5C+bioactive%5C+constituents%5C+of%5C+seven%5C+higher%5C+fungi%2C%5C+Boreostereum%5C+vibrans%2C%5C+Hexagonia%5C+speciosa%2C%5C+Panaeolus%5C+leucophanes%2C%5C+Gomphus%5C+purpuraceus%2C%5C+Sparassis%5C+crispa%2C%5C+Craterellus%5C+aureus%5C+and%5C+Hydnum%5C+repandum%5C+have%5C+been%5C+investigated.%5C+In%5C+chapter%5C+8%2C%5C+a%5C+review%5C+about%5C+the%5C+chemical%5C+and%5C+bioactivity%5C+of%5C+N%5C-containing%5C+compounds%5C+of%5C+macromycetes%5C+between%5C+2004%5C+and%5C+2009%5C+was%5C+given.100%5C+compounds%2C%5C+including%5C+36%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+the%5C+above%5C+mentioned%5C+seven%5C+species.%5C+Their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+methods%5C+in%5C+combination%5C+with%5C+single%5C-crystal%5C+X%5C-ray%5C+diffraction%5C+analysis.%5C+The%5C+type%5C+of%5C+the%5C+isolated%5C+compounds%5C+includes%5C+sesquiterpenoids%2C%5C+ergostols%2C%5C+isocoumarins%2C%5C+vibralactone%5C+derivertives%2C%5C+as%5C+well%5C+as%5C+oxygenated%5C+cyclohexanoids.Fourteen%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+basidiomycete%5C+Boreostereum%5C+vibrans%5C+%5C%28Berk%5C+%5C%26%5C+M.A.%5C+Curtis%5C+Davydkina%5C+%5C%26%5C+Bondartseva%5C+%5C%28Aphyllophorales%5C%29%5C%29.%5C+Among%5C+them%2C%5C+seven%5C+new%5C+ones%5C+were%5C+the%5C+vibralactone%5C+derivatives.%5C+1%2C5%5C-Secovibralactone%5C+and%5C+vibralactone%5C+C%5C+exhibited%5C+moderate%5C+inhibitory%5C+effect%5C+against%5C+human%5C+11%CE%B2%5C-HSD1%5C+but%5C+did%5C+not%5C+exhibit%5C+inhibition%5C+on%5C+11%CE%B2%5C-HSD2.%5C+Vibralactone%5C+B%2C%5C+vibralactone%5C+D%5C+and%5C+acetylated%5C+vibralactone%5C+showed%5C+inhibitory%5C+activities%5C+against%5C+both%5C+11%CE%B2%5C-HSD1%5C+and%5C+11%CE%B2%5C-HSD2.%5C+Twenty%5C+new%5C+oxygenated%5C+cyclohexanoids%5C+and%5C+a%5C+new%5C+acetylated%5C+aporpinone%5C+compounds%2C%5C+together%5C+with%5C+seven%5C+known%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+broth%5C+cultures%5C+of%5C+the%5C+basidiomycete%5C+Hexagonia%5C+speciosa.%5C+Their%5C+structures%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis%2C%5C+while%5C+the%5C+structure%5C+of%5C+8%5C+was%5C+confirmed%5C+by%5C+single%5C+crystal%5C+X%5C-ray%5C+diffraction%5C+data.Phytochemical%5C+study%5C+of%5C+the%5C+culture%5C+of%5C+Panaeolus%5C+leucophanes%5C+has%5C+resulted%5C+in%5C+the%5C+isolation%5C+of%5C+thirteen%5C+compounds%5C+which%5C+of%5C+eight%5C+were%5C+isocoumarins%2C%5C+including%5C+four%5C+new%5C+ones.%5C+Their%5C+structures%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis.%5C+A%5C+new%5C+alliacane%5C+sesquiterpene%2C%5C+together%5C+with%5C+5%5C+known%5C+compounds%2C%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+fruiting%5C+bodies%5C+of%5C+Gomphus%5C+purpuraceu.%5C+Their%5C+structures%5C+were%5C+elucidated%5C+by%5C+means%5C+of%5C+spectroscopic%5C+methods%5C+%5C%281D%5C+and%5C+2D%5C+NMR%2C%5C+MS%2C%5C+IR%5C%29.%5C+Five%5C+known%5C+compounds%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Sparassis%5C+crispa%2C%5C+and%5C+five%5C+from%5C+the%5C+fruiting%5C+bodies%5C+including%5C+two%5C+new%5C+compounds.%5C+Their%5C+structures%5C+were%5C+elucidated%5C+by%5C+means%5C+of%5C+spectroscopic%5C+methods%5C+%5C%281D%5C+and%5C+2D%5C+NMR%2C%5C+MS%2C%5C+IR%5C%29.%5C+A%5C+new%5C+hydroxyl%5C+acetylenic%5C+fatty%5C+acid%2C%5C+together%5C+with%5C+ten%5C+known%5C+compounds%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+fruiting%5C+bodies%5C+of%5C+Craterellus%5C+aureus%2C%5C+and%5C+their%5C+structures%5C+were%5C+elucidated%5C+by%5C+means%5C+of%5C+spectroscopic%5C+methods%5C+%5C%281D%5C+and%5C+2D%5C+NMR%2C%5C+MS%2C%5C+IR%5C%29.%5C+Eleven%5C+known%5C+compounds%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Hydnum%5C+repandum.%5C+Their%5C+structures%5C+were%5C+elucidated%5C+by%5C+means%5C+of%5C+spectroscopic%5C+methods%5C+%5C%281D%5C+NMR%2C%5C+MS%5C%29.In%5C+chapter%5C+8%2C%5C+the%5C+chemical%2C%5C+biological%2C%5C+and%5C+mycological%5C+literature%5C+dealing%5C+with%5C+the%5C+isolation%2C%5C+structure%5C+elucidation%2C%5C+biological%5C+activities%2C%5C+and%5C+synthesis%5C+of%5C+nitrogen%5C-containing%5C+compounds%5C+from%5C+the%5C+fruiting%5C+bodies%5C+and%5C+the%5C+culture%5C+broths%5C+of%5C+macromycetes%5C+were%5C+reviewed%5C+%5C%282004%5C-2009%5C%29."},{"jsname":"This dissertation is composed of five chapters, in which the chemical constituents of four medicinal plants, Hypoxis aurea Lour., Albizia mollis (Wall.) Boiv., Dobinea delavayi (Baill.) Baill. and Poria cococs (Schw.) Wolf, which are belonged to families of Hypoxidaceae, Leguminosae, Polyporaceae and Podoaceae, respectively, have been phytochemically studied. Chapter 5 reviews the chemical and bioactivities progresses of Albizia and Hypoxis genera. 79 compounds, including 12 new ones, were isolated from the above mentioned four species. All of the components were separated by column chromatography (siliga gel, sephadex LH-20, RP-18, RP-8 and half-preparation HPLC) and identified on the basis of extensive spectroscopic methods. The type of all compounds include phenolic glycosides, triterpenoids (lanosterol, oleanane type), diterpenoids (ent-kaurane type), eudesmane sesquiterpenes, lignanoids, ceramides, flavones, fatty acid (ester). We put forward a proposal that Albizia and Hypoxis genera should belong to Hypoxidaceae and be independent from Amaryllidaceae. Parts of compounds have been or being texted for antineoplastic, antidepressant.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E5%2580%258D%25E5%258D%258A%25E8%2590%259C&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+is%5C+composed%5C+of%5C+five%5C+chapters%2C%5C+in%5C+which%5C+the%5C+chemical%5C+constituents%5C+of%5C+four%5C+medicinal%5C+plants%2C%5C+Hypoxis%5C+aurea%5C+Lour.%2C%5C+Albizia%5C+mollis%5C+%5C%28Wall.%5C%29%5C+Boiv.%2C%5C+Dobinea%5C+delavayi%5C+%5C%28Baill.%5C%29%5C+Baill.%5C+and%5C+Poria%5C+cococs%5C+%5C%28Schw.%5C%29%5C+Wolf%2C%5C+which%5C+are%5C+belonged%5C+to%5C+families%5C+of%5C+Hypoxidaceae%2C%5C+Leguminosae%2C%5C+Polyporaceae%5C+and%5C+Podoaceae%2C%5C+respectively%2C%5C+have%5C+been%5C+phytochemically%5C+studied.%5C+Chapter%5C+5%5C+reviews%5C+the%5C+chemical%5C+and%5C+bioactivities%5C+progresses%5C+of%5C+Albizia%5C+and%5C+Hypoxis%5C+genera.%5C+79%5C+compounds%2C%5C+including%5C+12%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+the%5C+above%5C+mentioned%5C+four%5C+species.%5C+All%5C+of%5C+the%5C+components%5C+were%5C+separated%5C+by%5C+column%5C+chromatography%5C+%5C%28siliga%5C+gel%2C%5C+sephadex%5C+LH%5C-20%2C%5C+RP%5C-18%2C%5C+RP%5C-8%5C+and%5C+half%5C-preparation%5C+HPLC%5C%29%5C+and%5C+identified%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+methods.%5C+The%5C+type%5C+of%5C+all%5C+compounds%5C+include%5C+phenolic%5C+glycosides%2C%5C+triterpenoids%5C+%5C%28lanosterol%2C%5C+oleanane%5C+type%5C%29%2C%5C+diterpenoids%5C+%5C%28ent%5C-kaurane%5C+type%5C%29%2C%5C+eudesmane%5C+sesquiterpenes%2C%5C+lignanoids%2C%5C+ceramides%2C%5C+flavones%2C%5C+fatty%5C+acid%5C+%5C%28ester%5C%29.%5C+We%5C+put%5C+forward%5C+a%5C+proposal%5C+that%5C+Albizia%5C+and%5C+Hypoxis%5C+genera%5C+should%5C+belong%5C+to%5C+Hypoxidaceae%5C+and%5C+be%5C+independent%5C+from%5C+Amaryllidaceae.%5C+Parts%5C+of%5C+compounds%5C+have%5C+been%5C+or%5C+being%5C+texted%5C+for%5C+antineoplastic%2C%5C+antidepressant."},{"jsname":"lastIndexed","jscount":"2025-04-24"}],"Funding Project","dc.project.title_filter")'>
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多花蒿中流份 B 和 E 的抗肝癌活性成分研究
学位论文
: 中国科学院大学, 2022
Authors:
张鑫
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多花蒿，多花蒿素 A~L，吉玛烷型倍半萜，抗肝癌细胞毒活性
Artemisia myriantha, artemyrianosins A~L, germacrane sesquiterpenoids, antihepatoma activity
茵陈蒿和牛尾蒿的抗肝纤维化与抗肝癌活性成分研究
学位论文
: 中国科学院大学, 2022
Authors:
高振
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茵陈蒿，牛尾蒿，茵陈香豆酸，倍半萜二聚体，倍半萜，抗肝纤维化活性，抗肝癌活性，细胞周期，凋亡
Artemisia capillaris, Artemisia dubia, Coumaric acids, Sesquiterpenoids, Sesquiterpenoid dimers, Antihepatic fibrosis effects, Antihepatoma activity, Cell cycle, Apoptosis
西印度醋栗果实的化学成分研究
学位论文
: 中国科学院大学, 2022
Authors:
胥佳
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大戟科，西印度醋栗，化学成分，生物活性，营养分析
Euphorbiaceae, Phyllanthus acidus (L.) Skeels, Chemical constituents, Biological activity, Nutritional analysis
中药砂仁降血糖活性成分研究
学位论文
: 中国科学院大学, 2022
Authors:
丁敏
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砂仁，姜科，降木脂素，降血糖活性，促GLP-1分泌，GPa抑制活性
Amomum villosum
Zingiberaceae
norlignans
antidiabetic effects
GLP-1 stimulation
GPa inhibition
两种产地米团花的化学成分及其生物活性研究
学位论文
: 中国科学院大学, 2022
Authors:
张嫚雯
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米团花，化学成分，二倍半萜，二萜，生物活性
Leucosceptrum canum, Chemical constituents, Sesterterpenoids, Diterpenoids, Biological activities
几种唇形科植物萜类合酶及杂萜gwa-1组合生物合成研究
学位论文
: 中国科学院大学, 2022
Authors:
王安
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黄芩
Scutellaria baicalensis
半枝莲
Scutellaria barbata
萜类合酶
Terpenoid synthase
β-石竹烯合酶
β-caryophyllene synthase
大麻素类
Cannabinoid derivatives
愈创木烷倍半萜 ludartin 衍生物合成与抗 肝癌活性研究
学位论文
: 中国科学院大学, 2022
Authors:
孙金金
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Ludartin 衍生物合成
Synthesis of ludartin derivatives, Antihepatoma activity, HepG2 cells, Huh7 cells
抗肝癌活性
HepG2 细胞
Huh7 细胞
瘤枝五味子的化学成分及其生物活性研究
学位论文
: 中国科学院大学, 2022
Authors:
张水妹
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瘤枝五味子，木脂素，倍半萜，量子化学计算，神经保护活性
Schisandra bicolor var. tuberculata, Lignans, Sesquiterpenoids, Quantum chemical calculation, Neuroprotective activities
千日红和细梗美登木的化学成分与抗菌活性研究
学位论文
: 中国科学院大学, 2022
Authors:
徐祥娟
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千日红、细梗美登木、抗铜绿假单胞菌、抗MRSA
Gomphrena globosa, Maytenus graciliramula, Anti-Pseudomonas aeruginosa activities, Anti-MRSA activity
海菜花化学成分研究和Telekin的结构改造
学位论文
: 中国科学院大学, 2022
Authors:
曾政权
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天然产物、海菜花、天名精、倍半萜内酯、结构修饰
Natural Products, Ottelia acuminata, Carpesium abrotanoides L., Sesquiterpene lactone, Structural modification
