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Genomic and structural basis for evolution of tropane alkaloid biosynthesis 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 17, 页码: e2302448120
作者:  Wang,Yong-Jiang;  Tain,Tian;  Yu,Jia-Yi;  Li,Jie;  Xu,Bingyan;  Chen,Jianghua;  D'Auria,John C.;  Huang,Jian-Ping;  Huang,Sheng-Xiong
Adobe PDF(2613Kb)  |  收藏  |  浏览/下载：4/1  |  提交时间：2024/05/09
tropane alkaloids  evolution  biosynthesis  genome  structural biology  METHYLTRANSFERASE  REVEAL  
Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis 期刊论文
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 4994
作者:  Tian, Tian;  Wang, Yong-Jiang;  Huang, Jian-Ping;  Li, Jie;  Xu, Bingyan;  Chen, Yin;  Wang, Li;  Yang, Jing;  Yan, Yijun;  Huang, Sheng-Xiong
Adobe PDF(1664Kb)  |  收藏  |  浏览/下载：17/6  |  提交时间：2024/04/30
TROPANE ALKALOID BIOSYNTHESIS  CHAIN-LENGTH CONTROL  
Tropane alkaloid biosynthesis: a centennial review 期刊论文
NATURAL PRODUCT REPORTS, 2021, 卷号: 38, 期号: 9, 页码: 1634-1658
作者:  Huang,Jian-Ping;  Wang,Yong-Jiang;  Tian,Tian;  Wang,Li;  Yan,Yijun;  Huang,Sheng-Xiong
Adobe PDF(2786Kb)  |  收藏  |  浏览/下载：122/34  |  提交时间：2022/04/02
PUTRESCINE N-METHYLTRANSFERASE  TRANSFORMED ROOT CULTURES  2 TROPINONE REDUCTASES  ROLLE DES ACETATS  DATURA-STRAMONIUM  HYOSCYAMUS-NIGER  TOBACCO ALKALOIDS  ORNITHINE-DECARBOXYLASE  2-OXOGLUTARATE-DEPENDENT DIOXYGENASE  DIFFERENT STEREOSPECIFICITIES  
Biochemical and Metabolic Insights into Hyoscyamine Dehydrogenase 期刊论文
ACS CATALYSIS, 2021, 卷号: 11, 期号: 5, 页码: 2912-2924
作者:  Qiu,Fei;  Yan,Yijun;  Zeng,Junlan;  Huang,Jian-Ping;  Zeng,Lingjiang;  Zhong,Wei;  Lan,Xiaozhong;  Chen,Min;  Huang,Sheng-Xiong;  Liao,Zhihua
Adobe PDF(4893Kb)  |  收藏  |  浏览/下载：77/16  |  提交时间：2022/04/02
biosynthesis  crystal structure  hyoscyamine  hyoscyamine dehydrogenase  metabolic engineering  TROPANE ALKALOID BIOSYNTHESIS  TRANSGENIC ATROPA-BELLADONNA  POLYKETIDE SYNTHASE  ROOT CULTURES  SCOPOLAMINE  PUTRESCINE  PLANTS  6-BETA-HYDROXYLASE  CYTOCHROME-P450  PATHWAY  
Functional genomics analysis reveals two novel genes required for littorine biosynthesis 期刊论文
NEW PHYTOLOGIST, 2020, 卷号: 225, 期号: 5, 页码: 1906-1914
作者:  Qiu,Fei;  Zeng,Junlan;  Wang,Jing;  Huang,Jian-Ping;  Zhou,Wei;  Yang,Chunxian;  Lan,Xiaozhong;  Chen,Min;  Huang,Sheng-Xiong;  Kai,Guoyin;  Liao,Zhihua
Adobe PDF(1279Kb)  |  收藏  |  浏览/下载：181/64  |  提交时间：2020/04/02
Concise and efficient syntheses of methyl 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine 期刊论文
CANADIAN JOURNAL OF CHEMISTRY, 2020
作者:  Ma, Xiao-Yan;  Huang, Jian-Ping;  Yang, Jing;  Liu, Xingyong;  Hu, Xinjun;  Huang, Sheng-Xiong
Adobe PDF(201Kb)  |  收藏  |  浏览/下载：115/57  |  提交时间：2021/01/05
Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 8
作者:  Huang, Jian-Ping;  Fang, Chengli;  Ma, Xiaoyan;  Wang, Li;  Yang, Jing;  Luo, Jianying;  Yan, Yijun;  Zhang, Yu;  Huang, Sheng-Xiong
Adobe PDF(1048Kb)  |  收藏  |  浏览/下载：211/51  |  提交时间：2019/10/28
Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6 beta-hydroxylase gene 期刊论文
PLANT SCIENCE, 2019, 卷号: 283, 页码: 301-310
作者:  Schlesinger, Daniel;  Rikanati, Rachel Davidovich;  Volis, Sergei;  Faigenboim, Adi;  Vendramin, Vera;  Cattonaro, Federica;  Hooper, Matthew;  Oren, Elad;  Taylor, Mark;  Sitrit, Yaron;  Inbar, Moshe;  Lewinsohn, Efraim
Adobe PDF(5585Kb)  |  收藏  |  浏览/下载：182/36  |  提交时间：2019/07/29
Tropane alkaloids  Anisodamine  Hyoscyamine  Scopolamine  Solanaceae  Cleaved-amplified-polymorphic-sequence (CAPS) analyses  2-Oxoglutarate-dependent dioxygenases  
Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2, 页码: 8
作者:  He, Xin;  Yang, Jing;  Qiu, Ling;  Feng, Dan;  Ju, Feng;  Tan, Lu;  Li, Yu-Zhi;  Gu, Yu-Cheng;  Zhang, Zhen;  Guo, Da-Le;  Deng, Yun
Adobe PDF(2070Kb)  |  收藏  |  浏览/下载：138/29  |  提交时间：2019/03/18
Penicillium crustosum  Isaria cicadae  thiodiketopiperazines  Mosher analysis  ECD calculation  gastrointestinal motility  
Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 18, 页码: 4880-4883
作者:  Zhao, Jie;  Zhao, Xiao-Jing;  Cao, Pei;  Liu, Ji-Kai;  Wu, Bin
Adobe PDF(1162Kb)  |  收藏  |  浏览/下载：234/64  |  提交时间：2017/10/23
C-h Functionalization  c(Sp(3))-h Bonds  Beta-lactams  Stereoselective-synthesis  Organic-synthesis  Aliphatic-amines  Activation  Derivatives  Cyclization  Amidation