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Tropane alkaloid biosynthesis: a centennial review
Huang,Jian-Ping; Wang,Yong-Jiang; Tian,Tian; Wang,Li; Yan,Yijun; Huang,Sheng-Xiong
2021
Source PublicationNATURAL PRODUCT REPORTS
ISSN0265-0568
Volume38Issue:9Pages:1634-1658
AbstractCovering: 1917 to 2020 Tropane alkaloids (TAs) are a remarkable class of plant secondary metabolites, which are characterized by an 8-azabicyclo[3.2.1]octane (nortropane) ring. Members of this class, such as hyoscyamine, scopolamine, and cocaine, are well known for their long history as poisons, hallucinogens, and anaesthetic agents. Since the structure of the tropane ring system was first elucidated in 1901, organic chemists and biochemists have been interested in how these mysterious tropane alkaloids are assembled in vitro and in vivo. However, it was only in 2020 that the complete biosynthetic route of hyoscyamine and scopolamine was clarified, and their de novo production in yeast was also achieved. The aim of this review is to present the innovative ideas and results in exploring the story of tropane alkaloid biosynthesis in plants from 1917 to 2020. This review also highlights that Robinson's classic synthesis of tropinone, which is one hundred years old, is biomimetic, and underscores the importance of total synthesis in the study of natural product biosynthesis.
KeywordPUTRESCINE N-METHYLTRANSFERASE TRANSFORMED ROOT CULTURES 2 TROPINONE REDUCTASES ROLLE DES ACETATS DATURA-STRAMONIUM HYOSCYAMUS-NIGER TOBACCO ALKALOIDS ORNITHINE-DECARBOXYLASE 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE DIFFERENT STEREOSPECIFICITIES
DOI10.1039/d0np00076k
WOS IDWOS:000698386800007
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73626
Collection中国科学院昆明植物研究所
Affiliation1.[Huang, Jian-Ping
2.Wang, Yong-Jiang
3.Tian, Tian
4.Wang, Li
5.Yan, Yijun
6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, CAS Ctr Excellence Mol Plant Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
7.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
8.[Tian, Tian
9.Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710119, Peoples R China
Recommended Citation
GB/T 7714
Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,et al. Tropane alkaloid biosynthesis: a centennial review[J]. NATURAL PRODUCT REPORTS,2021,38(9):1634-1658.
APA Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,Wang,Li,Yan,Yijun,&Huang,Sheng-Xiong.(2021).Tropane alkaloid biosynthesis: a centennial review.NATURAL PRODUCT REPORTS,38(9),1634-1658.
MLA Huang,Jian-Ping,et al."Tropane alkaloid biosynthesis: a centennial review".NATURAL PRODUCT REPORTS 38.9(2021):1634-1658.
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