Tropane alkaloid biosynthesis: a centennial review

doi:10.1039/d0np00076k

KIB OpenIR

	Tropane alkaloid biosynthesis: a centennial review
	Huang,Jian-Ping ; Wang,Yong-Jiang ; Tian,Tian ; Wang,Li; Yan,Yijun ; Huang,Sheng-Xiong
	2021
发表期刊	NATURAL PRODUCT REPORTS
ISSN	0265-0568
卷号	38 期号:9 页码:1634-1658
摘要	Covering: 1917 to 2020 Tropane alkaloids (TAs) are a remarkable class of plant secondary metabolites, which are characterized by an 8-azabicyclo[3.2.1]octane (nortropane) ring. Members of this class, such as hyoscyamine, scopolamine, and cocaine, are well known for their long history as poisons, hallucinogens, and anaesthetic agents. Since the structure of the tropane ring system was first elucidated in 1901, organic chemists and biochemists have been interested in how these mysterious tropane alkaloids are assembled in vitro and in vivo. However, it was only in 2020 that the complete biosynthetic route of hyoscyamine and scopolamine was clarified, and their de novo production in yeast was also achieved. The aim of this review is to present the innovative ideas and results in exploring the story of tropane alkaloid biosynthesis in plants from 1917 to 2020. This review also highlights that Robinson's classic synthesis of tropinone, which is one hundred years old, is biomimetic, and underscores the importance of total synthesis in the study of natural product biosynthesis.
关键词	PUTRESCINE N-METHYLTRANSFERASE TRANSFORMED ROOT CULTURES 2 TROPINONE REDUCTASES ROLLE DES ACETATS DATURA-STRAMONIUM HYOSCYAMUS-NIGER TOBACCO ALKALOIDS ORNITHINE-DECARBOXYLASE 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE DIFFERENT STEREOSPECIFICITIES
DOI	10.1039/d0np00076k
WOS记录号	WOS:000698386800007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73626
专题	中国科学院昆明植物研究所
作者单位	1.[Huang, Jian-Ping 2.Wang, Yong-Jiang 3.Tian, Tian 4.Wang, Li 5.Yan, Yijun 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, CAS Ctr Excellence Mol Plant Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 7.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 8.[Tian, Tian 9.Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710119, Peoples R China
推荐引用方式 GB/T 7714	Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,et al. Tropane alkaloid biosynthesis: a centennial review[J]. NATURAL PRODUCT REPORTS,2021,38(9):1634-1658.
APA	Huang,Jian-Ping,Wang,Yong-Jiang,Tian,Tian,Wang,Li,Yan,Yijun,&Huang,Sheng-Xiong.(2021).Tropane alkaloid biosynthesis: a centennial review.NATURAL PRODUCT REPORTS,38(9),1634-1658.
MLA	Huang,Jian-Ping,et al."Tropane alkaloid biosynthesis: a centennial review".NATURAL PRODUCT REPORTS 38.9(2021):1634-1658.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
159-I21-072-黄建萍-Nat.（2786KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载