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Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：395/44  |  提交时间：2017/12/18
Sauruchinenols A and B, unprecedented monocyclic diterpenes with new carbon skeleton from the aerial parts of Saururus chinensis 期刊论文
FITOTERAPIA, 2017, 卷号: 116, 页码: 116-120
作者:  Gao, Xiu;  He, Juan;  Wu, Xing-De;  Peng, Li-Yan;  Shao, Li-Dong;  Li, Yan;  Cheng, Xiao;  Zhao, Qin-Shi
浏览  |  Adobe PDF(503Kb)  |  收藏  |  浏览/下载：349/41  |  提交时间：2017/04/18
Saururus Chinensis  Saururaceae  Sauruchinenols A-d  Anti-no Production  
Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation 期刊论文
CANCER RESEARCH, 2016, 卷号: 76, 期号: 9, 页码: 2698-2709
作者:  Yu, Zu-Yin;  Xiao, He;  Wang, Li-Mei;  Shen, Xing;  Jing, Yu;  Wang, Lin;  Sun, Wen-Feng;  Zhang, Yan-Feng;  Cui, Yu;  Shan, Ya-Jun;  Zhou, Wen-Bing;  Xing, Shuang;  Xiong, Guo-Lin;  Liu, Xiao-Lan;  Dong, Bo;  Feng, Jian-Nan;  Wang, Li-Sheng;  Luo, Qing-Liang;  Zhao, Qin-Shi;  Cong, Yu-Wen
Adobe PDF(1368Kb)  |  收藏  |  浏览/下载：298/98  |  提交时间：2016/08/22
Natural product vibsanine A induces differentiation of myeloid leukemia cells through PKC activation 期刊论文
Cancer Research, 2016, 期号: 1, 页码: 1
作者:  Zhao QS(赵勤实)
浏览  |  Adobe PDF(1368Kb)  |  收藏  |  浏览/下载：148/49  |  提交时间：2017/02/28
Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis 期刊论文
JOURNAL OF IMMUNOLOGY, 2015, 卷号: 194, 期号: 9, 页码: 4489-4497
作者:  Ye, Bai-Xin;  Deng, Xu;  Shao, Li-Dong;  Lu, Ying;  Xiao, Run;  Liu, Yi-Jie;  Jin, Yi;  Xie, Yin-Yin;  Zhao, Yan;  Luo, Liu-Fei;  Ma, Shun;  Gao, Ming;  Zhang, Lian-Ru;  He, Juan;  Zhang, Wei-Na;  Chen, Yi;  Xia, Cheng-Feng;  Deng, Min;  Liu, Ting-Xi;  Zhao, Qin-Shi;  Chen, Sai-Juan;  Chen, Zhu;  Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China.;  qinshizhao@mail.kib.ac.cn;  sjchen@stn.sh.cn;  zchen@stn.sh.cn
浏览  |  Adobe PDF(1516Kb)  |  收藏  |  浏览/下载：286/46  |  提交时间：2015/07/20
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
浏览  |  Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：301/79  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 3, 页码: 841-852
作者:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Li, Jingxia;  Deng, Xu;  Zhao, Qin-shi;  Huang, Chuanshu
浏览  |  Adobe PDF(3282Kb)  |  收藏  |  浏览/下载：324/69  |  提交时间：2014/05/16
Cheliensisin a  Apoptosis  Colon Cancer  P53  Chemotherapeutic Agent  
New Lycopodium alkaloids from Phlegmariurus squarrosus 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 卷号: 16, 期号: 6, 页码: 574-580
作者:  Liu, Fei;  Dong, Liao-Bin;  Gao, Xiu;  Wu, Xing-De;  He, Juan;  Peng, Li-Yan;  Cheng, Xiao;  Zhao, Qin-Shi;  Zhao, QS (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China.;  qinshizhao@mail.kib.ac.cn
浏览  |  Adobe PDF(218Kb)  |  收藏  |  浏览/下载：214/43  |  提交时间：2014/10/11
Phlegmariurus Squarrosus  Lycopodium Alkaloids  8 Alpha-hydroxylycojapodine a  8 Beta-acetoxy-12 Beta-hydroxy-epidihydrolycopodine  8 Beta-acetyllycoposerramine-u  11 Beta-acetoxyl-n-methylhuperzine b  
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：415/155  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：323/71  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol