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An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
Adobe PDF(523Kb)  |  收藏  |  浏览/下载：73/19  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：82/29  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
New cytotoxic dichapetalins in the leaves of Phyllanthus acidus: Identification, quantitative analysis, and preliminary toxicity assessment 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105125
作者:  Geng,Hui-Chun;  Zhu,Hong-Tao;  Yang,Wei-Nong;  Wang,Dong;  Yang,Chong-Ren;  Zhang,Ying-Jun
浏览  |  Adobe PDF(774Kb)  |  收藏  |  浏览/下载：81/14  |  提交时间：2022/04/02
Phyllanthus acidus  Euphorbiaceae  Dichapetalins  Pacidusins A-D  Cytotoxicity  TRITERPENOIDS  CONSTITUENTS  
Structurally diverse lanostane triterpenoids from medicinal and edible mushroom Ganoderma resinaceum Boud 期刊论文
BIOORGANIC CHEMISTRY, 2020
作者:  Shi, Qiang-Qiang;  Huang, Yan-Jie;  Su, Hai-Guo;  Gao, Ya;  Lu, Shuang-Yang;  Peng, Xing-Rong;  Li, Xiao-Nian;  Zhou, Lin;  Qiu, Ming-Hua
浏览  |  Adobe PDF(1645Kb)  |  收藏  |  浏览/下载：99/23  |  提交时间：2021/01/05
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
浏览  |  Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：189/30  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine