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NF-kappa B and JNK mediated apoptosis and G(0)/G(1) arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 220, 页码: 220-227
作者:  Zeng, Guang-Zhi;  Wang, Zhe;  Zhao, Li-Mei;  Fan, Jun-Ting;  Tan, Ning-Hua
收藏  |  浏览/下载：248/0  |  提交时间：2018/07/16
Rubiarbonol g  Rubia Yunnanensis  Cytotoxicity  Mechanism  
Stereochemical assignments of rubiaquinones A-C, naphthoquinone derivatives from &ITRubia yunnanensis&IT 期刊论文
TETRAHEDRON LETTERS, 2017, 卷号: 58, 期号: 48, 页码: 4568-4571
作者:  Suyama, Yoshihiro;  Higashino, Yusuke;  Tanaka, Naonobu;  Tatano, Yutaka;  Yagi, Hideki;  Kawazoe, Kazuyoshi;  Murakami, Kotaro;  Li, Shun-Lin;  Sun, Han-Dong;  Kashiwada, Yoshiki
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Naphthoquinone Derivative  Rubiaquinones A-c  Stereochemical Assignment  Composite Ecd Spectrum  Rubia Yunnanensis  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 卷号: 164, 期号: 7, 页码: 1883-1898
作者:  Yue, Grace G. L.;  Fan, Jun-Ting;  Lee, Julia K. M.;  Zeng, Guang-Zhi;  Ho, Tina W. F.;  Fung, Kwok-Pui;  Leung, Ping-Chung;  Tan, Ning-Hua;  Lau, Clara B. S.
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Cyclopeptide  Ra-v  Angiogenesis  Erk1  2  Rubia Yunnanensis  Huvec  Hmec-1  Endothelial Cells  
Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis 期刊论文
TETRAHEDRON LETTERS, 2010, 卷号: 51, 期号: 52, 页码: 6810-6813
作者:  Fan, Jun-Ting;  Chen, Yi-Shan;  Xu, Wen-Yan;  Du, Liangcheng;  Zeng, Guang-Zhi;  Zhang, Yu-Mei;  Su, Jia;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(444Kb)  |  收藏  |  浏览/下载：415/149  |  提交时间：2012/03/21
Rubia Yunnanensis  Rubiyunnanin a  Rubiyunnanin b  Cyclopeptides  Cytotoxicity  Inhibition Of No Production  
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 卷号: 18, 期号: 23, 页码: 8226-8234
作者:  Fan, Jun-Ting;  Su, Jia;  Peng, Yan-Min;  Li, Yan;  Li, Jia;  Zhou, Yu-Bo;  Zeng, Guang-Zhi;  Yan, He;  Tan, Ning-Hua
Adobe PDF(424Kb)  |  收藏  |  浏览/下载：450/181  |  提交时间：2012/03/21
Rubia Yunnanensis  Rubiyunnanins C-h  Cyclopeptides  Cytotoxicity  Inhibition Of No Production  Nf-kappa b Pathway Inhibitors