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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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GST, P < 0.05) were exhibited by this species. The SAMOVA revealed seven diverging groups of related chlorotypes, six of them had distinct nonoverlapping geographical ranges: one in the northeast comprising 10 populations, a second with a southeast distribution comprising 22 populations, and the remaning four groups comprising 15 populations located in the west part of the species’ range along different river valleys. The genetic clustering of populations into three regions was also supported by analysis of molecular variance, which showed that most genetic variation (82.43%) was found among these three regions. Two clusters were distinguished by both phylogenetic analysis and genealogical analysis of chlorotypes, one consisting of chlorotypes from the western region and the second consisting of those from the eastern region. Significant genetic differences between the two regions might be attributed to vicariance and restricted gene flow, and this vicariance could be explained by the physical environmental heterogeneity on each side of the Tanaka-Kaiyong Line. Following the uplift of the Tibetan Plateau, the reorganization of the major river drainages was primarily caused by river separation and capture events. These historical events could change the distribution of S. davidii from fragmented to continuous (Upper/Lower Jinshajiang and Yalongjiang/Daduhe), and from continuous to fragmented (Nujiang and Jinshajiang/Honghe). However, spatial and temporal patterns of phylogeographic divergence are strongly associated with historical disjunction rather than modern drainage connections. Moreover, the following north-south split in the eastern region and effective isolation with their genetic diversity were essentially modelled by genetic drift. The higher chlorotype richness and genetic divergence for populations in western region compared with other two regions suggests that there were multipe refugia or in situ survival of S. davidii in the Himalayan-Hengduan Mountain region. Fixation of chlorotypes in the northeastern region and near fixation in the southeastern region suggest a recent colonization of these areas. We further found that this species underwent past range expansion around 37-303 thousand years ago (kya). The southeastern populations likely experienced a demographic expansion via unidirectional gene flow along rivers, while northeastern populations underwent a more northward expansion, both from initial populations (s) (21, 22, 23) preserved on eastern refugia (Jinshajiang). This process might have been accompanied with a series of founder effects or bottlenecks making populations genetically impoverished. 3. Phylogeographic analysisbased on nuclear sequence，We sequenced the nuclear (ncpGS) region in all populations sampled, recovering 23 nuclear haplotypes. Compared to cpDNA, both NST (0.470) and GST (0.338) were relatively lower, but NST was also significantly larger than GST. 37.10% of the total variation was distributed among regions which was much lower than that shown by chlorotypes. Thus, more extensive distribution of nuclear haplotypes was exhibited across the geographical range instead of the strong population subdivision observed in chlorotypes. Similarly to the chloroplast data, we found that genetic differentiation of nDNA was positively correlated with the geographical distance, but the increase in the geographical distance between populations did not increase the genetic differentiation of nDNA as rapidly as that of cpDNA. These contrasting levels between the chloroplast and nuclear genomes of S. davidii are likely due to limited gene flow of cpDNA by seeds vs. the extensive gene flow of nDNA by wind-mediated pollen in the population history. We also determined from nuclear markers that haplotype diversity was reduced in the southeastern and northeastern regions due to the loss of rare haplotypes in western region. This reduction of gene diversity is also a signature of founder events or recent bottleneck during post-glacial colonization. However, nuclear diversity within populations remains high. This provides evidence that regionally pollen flow might be sufficiently high to blur the genetic identity of founder populations over a reasonably large spatial scale.3. Relationships among three varieties，The phylogenetic analysis identified two phylogroups of chlorotypes, corresponding to S. davidii var. davidii and var. chuansinesis. The former was distinguished by the abscence of predonminant nuclear haplotype H1 of the latter. The monophyletic group of chlorotypes in var. davidii and var. liangshanesis showed their relatively close relationship. And their genetic divergence from the third variety appears to be relative to their slight morphological difference in leaf size and the divergent environmental niche spaces they occupy. Thus, the observed differences in morphological characters between var. chuansinesis and other two varieties can be explained by the seed dispersal limitation illustrated above (as inferred by geographical separation) and by environmental heterogeneity (as inferred by precipitation or elevation) or by a combination of both. After all, the geological changes, drainage reorganization, and floristic differences following the Himalayan uplift have been suggested to affect the genetic structure of S. davidii. These results provide new insights into the phylogeographic pattern of plants in China. In addition, the unique population genetic structure found in S. davidii has provided important insights into the evolutionary history of this species. The genetic profile uncovered in this study is also critical for its conservation management. Our study has uncovered the existence of at least two ‘evolutionary significant units’ independent units within S. davidii, corresponding to var. davidii from eastern region and var. chuansinensis from western region. The conservation efforts should first focus on most western populations and on the southeastern ones exhibiting high levels of genetic diversity, while the genetically homogeneous northeastern populations located in the degraded Loess Plateau should require much greater conservation 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chemical constituents of eight higher fungi and one medicinal plant were investigated. The fungi included Trametes corrugate, Campanella junghuhnii, Craterellus cornucopioides, Phlebia radiate, Laccaria amethystea, Hydnochaete sp., Nidula sp. and Rhodophyllus ater, which are all collected from Yunnan province, P. R. China. The leaves of Cynara scolymus L. (Artichoke) were collected from south of Vietnam. 119 compounds, including 91 different compounds and 9 new ones, have been obtained using varied chromatographic methods, and the structures of new metabolites were elucidated on the basis of extensive spectroscopic analysis including IR, UV, MS, 1D- and 2D-NMR experiments.Two unusual diterpenes (13-14) with neodolastane skeletons were isolated and identified from the culture broth of Trametes corrugate. This type of diterpene was obtained for the first time from higer fungi. A new tricyclo[6.3.1.02,5]dodecane sesquiterpene (1) was isolated from the culture broth of Campanella junghuhnii. Three new keto esters (65-67) and a series of illudine sesquiterpenes (4-10) were isolated and identified from the culture broth of the basidiomycete Craterellus cornucopioides. A new fatty acid ester (48) was isolated from the culture broth of Phlebia radiate.A new isoprenyl phenyl ether riboside (68) was isolated from culture broth of Laccaria amethystea. During our studies on chemical constituents of the culture broth of Hydnochaete sp., a conjugate lactone (71) was obtained. Preliminary biological assay showed that the lactone exhibited inhibitory activity against the11b-hydroxysteroid dehydrogenase (11β-HSD1) of human and mouse with IC50 value of 53.338 mg/mL and 95.950 mg/mL, respectively. A new guaiane-type sesquiterpene lactone (2) and a new phenolic glucoside gallate (69) were isolated and identified from the leaves of Cynara scolymus (Artichoke). A review summarized their structures, biological activities, and the producing species of naturally occurring triterpenes from higher fungi. The paper provides 433 structurally diverse compounds published between 1985~2010, and 114 references.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+chemical%5C+constituents%5C+of%5C+eight%5C+higher%5C+fungi%5C+and%5C+one%5C+medicinal%5C+plant%5C+were%5C+investigated.%5C+The%5C+fungi%5C+included%5C+Trametes%5C+corrugate%2C%5C+Campanella%5C+junghuhnii%2C%5C+Craterellus%5C+cornucopioides%2C%5C+Phlebia%5C+radiate%2C%5C+Laccaria%5C+amethystea%2C%5C+Hydnochaete%5C+sp.%2C%5C+Nidula%5C+sp.%5C+and%5C+Rhodophyllus%5C+ater%2C%5C+which%5C+are%5C+all%5C+collected%5C+from%5C+Yunnan%5C+province%2C%5C+P.%5C+R.%5C+China.%5C+The%5C+leaves%5C+of%5C+Cynara%5C+scolymus%5C+L.%5C+%5C%28Artichoke%5C%29%5C+were%5C+collected%5C+from%5C+south%5C+of%5C+Vietnam.%5C+119%5C+compounds%2C%5C+including%5C+91%5C+different%5C+compounds%5C+and%5C+9%5C+new%5C+ones%2C%5C+have%5C+been%5C+obtained%5C+using%5C+varied%5C+chromatographic%5C+methods%2C%5C+and%5C+the%5C+structures%5C+of%5C+new%5C+metabolites%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis%5C+including%5C+IR%2C%5C+UV%2C%5C+MS%2C%5C+1D%5C-%5C+and%5C+2D%5C-NMR%5C+experiments.Two%5C+unusual%5C+diterpenes%5C+%5C%2813%5C-14%5C%29%5C+with%5C+neodolastane%5C+skeletons%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Trametes%5C+corrugate.%5C+This%5C+type%5C+of%5C+diterpene%5C+was%5C+obtained%5C+for%5C+the%5C+first%5C+time%5C+from%5C+higer%5C+fungi.%5C+A%5C+new%5C+tricyclo%5C%5B6.3.1.02%2C5%5C%5Ddodecane%5C+sesquiterpene%5C+%5C%281%5C%29%5C+was%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Campanella%5C+junghuhnii.%5C+Three%5C+new%5C+keto%5C+esters%5C+%5C%2865%5C-67%5C%29%5C+and%5C+a%5C+series%5C+of%5C+illudine%5C+sesquiterpenes%5C+%5C%284%5C-10%5C%29%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+the%5C+basidiomycete%5C+Craterellus%5C+cornucopioides.%5C+A%5C+new%5C+fatty%5C+acid%5C+ester%5C+%5C%2848%5C%29%5C+was%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Phlebia%5C+radiate.A%5C+new%5C+isoprenyl%5C+phenyl%5C+ether%5C+riboside%5C+%5C%2868%5C%29%5C+was%5C+isolated%5C+from%5C+culture%5C+broth%5C+of%5C+Laccaria%5C+amethystea.%5C+During%5C+our%5C+studies%5C+on%5C+chemical%5C+constituents%5C+of%5C+the%5C+culture%5C+broth%5C+of%5C+Hydnochaete%5C+sp.%2C%5C+a%5C+conjugate%5C+lactone%5C+%5C%2871%5C%29%5C+was%5C+obtained.%5C+Preliminary%5C+biological%5C+assay%5C+showed%5C+that%5C+the%5C+lactone%5C+exhibited%5C+inhibitory%5C+activity%5C+against%5C+the11b%5C-hydroxysteroid%5C+dehydrogenase%5C+%5C%2811%CE%B2%5C-HSD1%5C%29%5C+of%5C+human%5C+and%5C+mouse%5C+with%5C+IC50%5C+value%5C+of%5C+53.338%5C+mg%5C%2FmL%5C+and%5C+95.950%5C+mg%5C%2FmL%2C%5C+respectively.%5C+A%5C+new%5C+guaiane%5C-type%5C+sesquiterpene%5C+lactone%5C+%5C%282%5C%29%5C+and%5C+a%5C+new%5C+phenolic%5C+glucoside%5C+gallate%5C+%5C%2869%5C%29%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+leaves%5C+of%5C+Cynara%5C+scolymus%5C+%5C%28Artichoke%5C%29.%5C+A%5C+review%5C+summarized%5C+their%5C+structures%2C%5C+biological%5C+activities%2C%5C+and%5C+the%5C+producing%5C+species%5C+of%5C+naturally%5C+occurring%5C+triterpenes%5C+from%5C+higher%5C+fungi.%5C+The%5C+paper%5C+provides%5C+433%5C+structurally%5C+diverse%5C+compounds%5C+published%5C+between%5C+1985%5C%7E2010%2C%5C+and%5C+114%5C+references."},{"jsname":"The chemistry constitutes and their anti-tobacco mosic virus activity from two species of Simaroubeaceae, namely Brucea javanica (L) Merr. and Harrisonia perforata (Blanco) Merr have been investigated.. By variety of chromatographies over various materials, Eighty-seven compounds were isolated from the two plants and eighty of them were identified， of which twenty-two were new compounds and one of them was a novel nortriterpenoids with unprecedented skeleton and another showed the polymorphism. A series of C-20 quassinoids with potent anti-tobacco mosic virus (TMV) activity was found by the bioassay-guided isolation of the seed of Brucea javanica. The characteristic secondary metabolites of Simaroubeaceae--quassinoids were reviewed. Chapter 1, phytochemistry investigation on the seed of Brucea javanica (L) Merr. has led to isolation of 41 compounds, and 34 of them were identified, including 17 quassinoids with anti-TMV activity. Among them compounds 1 and 2 were new quassinoids. Others were alkaloids, ligands, sequiterpenoids, and so on. Chapter 2, tobacco mosic virus inhibiting activity of quassinoids from Brucea javanica (L) Merr. From bioassay-guide isolation 17 quassinoids with potent anti-TMV activities were isolated from the seeds of Brucea javanica (L) Merr. Based on the results of in vivo and in vitro experiments, it was showed that those compounds can both inhibit virus infection and multiplication of TMV. The anti-TMV structure activity relationships were also discussed. Chapter 3, phytochemistry investigation on the leaves and branches of H. perforata has lead to isolation of 32 compounds and 31 were identified, including 20 new limonoids. Among them 1 was a novel limonoids with unprecedented skeleton, and another showed the polymorphism. Besides, 14 compounds, including 8 limonoids along with some triterpenoids, ligands and flavonoids were isolated from the fruit of H. perforata. Among the 14 compounds 1-3 were novel limonoids which have been isolated from the leaves and branches of this species. The limonoids isolated from H. perforata showed structure similarity with those from the Ptaeroxylaceae and Cneoraceae. Furthermore, most of them were the key intermediates of the biogenetic pathway previously proposed by Dr. Xin Fang of our research group. Based on the biogenetic pathway and structure similarity of limonoids it was suggested that the genus of Harrisonia has a very close relationship with Ptaeroxylaceae and Cneoraceae. Chapter 4, reviewed the progress on the phytochemistry study of the quassinoids of Simaroubaceae. The bioactivities along with proposed biogenetic pathway involving quassinoids reported from the Simaroubeaceae were systemically.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+chemistry%5C+constitutes%5C+and%5C+their%5C+anti%5C-tobacco%5C+mosic%5C+virus%5C+activity%5C+from%5C+two%5C+species%5C+of%5C+Simaroubeaceae%2C%5C+namely%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+and%5C+Harrisonia%5C+perforata%5C+%5C%28Blanco%5C%29%5C+Merr%5C+have%5C+been%5C+investigated..%5C+By%5C+variety%5C+of%5C+chromatographies%5C+over%5C+various%5C+materials%2C%5C+Eighty%5C-seven%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+two%5C+plants%5C+and%5C+eighty%5C+of%5C+them%5C+were%5C+identified%EF%BC%8C%5C+of%5C+which%5C+twenty%5C-two%5C+were%5C+new%5C+compounds%5C+and%5C+one%5C+of%5C+them%5C+was%5C+a%5C+novel%5C+nortriterpenoids%5C+with%5C+unprecedented%5C+skeleton%5C+and%5C+another%5C+showed%5C+the%5C+polymorphism.%5C+A%5C+series%5C+of%5C+C%5C-20%5C+quassinoids%5C+with%5C+potent%5C+anti%5C-tobacco%5C+mosic%5C+virus%5C+%5C%28TMV%5C%29%5C+activity%5C+was%5C+found%5C+by%5C+the%5C+bioassay%5C-guided%5C+isolation%5C+of%5C+the%5C+seed%5C+of%5C+Brucea%5C+javanica.%5C+The%5C+characteristic%5C+secondary%5C+metabolites%5C+of%5C+Simaroubeaceae%5C-%5C-quassinoids%5C+were%5C+reviewed.%5C+Chapter%5C+1%2C%5C+phytochemistry%5C+investigation%5C+on%5C+the%5C+seed%5C+of%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+has%5C+led%5C+to%5C+isolation%5C+of%5C+41%5C+compounds%2C%5C+and%5C+34%5C+of%5C+them%5C+were%5C+identified%2C%5C+including%5C+17%5C+quassinoids%5C+with%5C+anti%5C-TMV%5C+activity.%5C+Among%5C+them%5C+compounds%5C+1%5C+and%5C+2%5C+were%5C+new%5C+quassinoids.%5C+Others%5C+were%5C+alkaloids%2C%5C+ligands%2C%5C+sequiterpenoids%2C%5C+and%5C+so%5C+on.%5C+Chapter%5C+2%2C%5C+tobacco%5C+mosic%5C+virus%5C+inhibiting%5C+activity%5C+of%5C+quassinoids%5C+from%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+From%5C+bioassay%5C-guide%5C+isolation%5C+17%5C+quassinoids%5C+with%5C+potent%5C+anti%5C-TMV%5C+activities%5C+were%5C+isolated%5C+from%5C+the%5C+seeds%5C+of%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+Based%5C+on%5C+the%5C+results%5C+of%5C+in%5C+vivo%5C+and%5C+in%5C+vitro%5C+experiments%2C%5C+it%5C+was%5C+showed%5C+that%5C+those%5C+compounds%5C+can%5C+both%5C+inhibit%5C+virus%5C+infection%5C+and%5C+multiplication%5C+of%5C+TMV.%5C+The%5C+anti%5C-TMV%5C+structure%5C+activity%5C+relationships%5C+were%5C+also%5C+discussed.%5C+Chapter%5C+3%2C%5C+phytochemistry%5C+investigation%5C+on%5C+the%5C+leaves%5C+and%5C+branches%5C+of%5C+H.%5C+perforata%5C+has%5C+lead%5C+to%5C+isolation%5C+of%5C+32%5C+compounds%5C+and%5C+31%5C+were%5C+identified%2C%5C+including%5C+20%5C+new%5C+limonoids.%5C+Among%5C+them%5C+1%5C+was%5C+a%5C+novel%5C+limonoids%5C+with%5C+unprecedented%5C+skeleton%2C%5C+and%5C+another%5C+showed%5C+the%5C+polymorphism.%5C+Besides%2C%5C+14%5C+compounds%2C%5C+including%5C+8%5C+limonoids%5C+along%5C+with%5C+some%5C+triterpenoids%2C%5C+ligands%5C+and%5C+flavonoids%5C+were%5C+isolated%5C+from%5C+the%5C+fruit%5C+of%5C+H.%5C+perforata.%5C+Among%5C+the%5C+14%5C+compounds%5C+1%5C-3%5C+were%5C+novel%5C+limonoids%5C+which%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+leaves%5C+and%5C+branches%5C+of%5C+this%5C+species.%5C+The%5C+limonoids%5C+isolated%5C+from%5C+H.%5C+perforata%5C+showed%5C+structure%5C+similarity%5C+with%5C+those%5C+from%5C+the%5C+Ptaeroxylaceae%5C+and%5C+Cneoraceae.%5C+Furthermore%2C%5C+most%5C+of%5C+them%5C+were%5C+the%5C+key%5C+intermediates%5C+of%5C+the%5C+biogenetic%5C+pathway%5C+previously%5C+proposed%5C+by%5C+Dr.%5C+Xin%5C+Fang%5C+of%5C+our%5C+research%5C+group.%5C+Based%5C+on%5C+the%5C+biogenetic%5C+pathway%5C+and%5C+structure%5C+similarity%5C+of%5C+limonoids%5C+it%5C+was%5C+suggested%5C+that%5C+the%5C+genus%5C+of%5C+Harrisonia%5C+has%5C+a%5C+very%5C+close%5C+relationship%5C+with%5C+Ptaeroxylaceae%5C+and%5C+Cneoraceae.%5C+Chapter%5C+4%2C%5C+reviewed%5C+the%5C+progress%5C+on%5C+the%5C+phytochemistry%5C+study%5C+of%5C+the%5C+quassinoids%5C+of%5C+Simaroubaceae.%5C+The%5C+bioactivities%5C+along%5C+with%5C+proposed%5C+biogenetic%5C+pathway%5C+involving%5C+quassinoids%5C+reported%5C+from%5C+the%5C+Simaroubeaceae%5C+were%5C+systemically."},{"jsname":"The dissertation deals with the chemical constituents of six plants, Brainea insignis, Dipteris chinensis, Lygodium japonicum, Hypericum lagarocladum, Hypericum androsaemum, and Uncaria macrophylla. More than 100 compounds, including 18 new ones, were obtained using varied chromatography methods, and the structures of them were elucidated on the basis of extensive spectroscopic analysis. The classifications of new compounds include flavonoids, diterpenoids, polycyclic polyprenylated acylphloroglucinols (PPAPs), and oxindole alkaloids, etc. Brainicin was an unusual flavan derivative with a linkage between C-4 of epicatechin and the side chain of a phenylpropyl unit isolated from B. insignis. The type of linkage was found for the first time in nature. A series of new polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing a spirocyclic skeleton, were found in H. lagarocladum. Hyperandrone A, a complex adamantyl derivative was the first example of PPAPs from H. androsaemum. Macrophyllionium, the first example of a zwitterionic oxindole alkaloid was isolated from the aerial parts of U. macrophylla. It extended the structural variety of the known betaines. Macrophyllines A and B were a pair of isomers with acetonyl in skeleton compared with other analogues, and they were proved to be natural products. In addition, some compounds were evaluated for their cytotoxicity against five human cancer cell lines and vasodilative effects on KCl-/phenylephrine (PE)-induced contraction. As a result, corynantheidine exhibited cytotoxicity against HL-60 and SW480 cells with IC50 values of 13.96 and 23.28 μM, respectively; macrophylline A, isorhynchophylline, and dihydrocorynantheine showed strong inhibitory action on KCl-/PE-induced contraction. It was noteworthy that dihydrocorynantheine almost inhibited completely PE-induced contraction in rats thoracic aorta at 30 μg/ml. In contrast to the relatively smaller inhibitory effects of verapamil on PE-induced contraction at 3 and 10 μg/ml, dihydrocorynantheine showed significant inhibitory actions. It was shown to be a potent vasorelaxant of aorta. Finally, a review titled advances of chemistry and pharmacology of the genus Uncaria is presented.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+dissertation%5C+deals%5C+with%5C+the%5C+chemical%5C+constituents%5C+of%5C+six%5C+plants%2C%5C+Brainea%5C+insignis%2C%5C+Dipteris%5C+chinensis%2C%5C+Lygodium%5C+japonicum%2C%5C+Hypericum%5C+lagarocladum%2C%5C+Hypericum%5C+androsaemum%2C%5C+and%5C+Uncaria%5C+macrophylla.%5C+More%5C+than%5C+100%5C+compounds%2C%5C+including%5C+18%5C+new%5C+ones%2C%5C+were%5C+obtained%5C+using%5C+varied%5C+chromatography%5C+methods%2C%5C+and%5C+the%5C+structures%5C+of%5C+them%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis.%5C+The%5C+classifications%5C+of%5C+new%5C+compounds%5C+include%5C+flavonoids%2C%5C+diterpenoids%2C%5C+polycyclic%5C+polyprenylated%5C+acylphloroglucinols%5C+%5C%28PPAPs%5C%29%2C%5C+and%5C+oxindole%5C+alkaloids%2C%5C+etc.%5C+Brainicin%5C+was%5C+an%5C+unusual%5C+flavan%5C+derivative%5C+with%5C+a%5C+linkage%5C+between%5C+C%5C-4%5C+of%5C+epicatechin%5C+and%5C+the%5C+side%5C+chain%5C+of%5C+a%5C+phenylpropyl%5C+unit%5C+isolated%5C+from%5C+B.%5C+insignis.%5C+The%5C+type%5C+of%5C+linkage%5C+was%5C+found%5C+for%5C+the%5C+first%5C+time%5C+in%5C+nature.%C2%A0A%5C+series%5C+of%5C+new%5C+polycyclic%5C+polyprenylated%5C+acylphloroglucinols%5C+%5C%28PPAPs%5C%29%5C+possessing%5C+a%5C+spirocyclic%5C+skeleton%2C%5C+were%5C+found%5C+in%5C+H.%5C+lagarocladum.%5C+Hyperandrone%5C+A%2C%5C+a%5C+complex%5C+adamantyl%5C+derivative%5C+was%5C+the%5C+first%5C+example%5C+of%5C+PPAPs%5C+from%5C+H.%5C+androsaemum.%5C+Macrophyllionium%2C%5C+the%5C+first%5C+example%5C+of%5C+a%5C+zwitterionic%5C+oxindole%5C+alkaloid%5C+was%5C+isolated%5C+from%5C+the%5C+aerial%5C+parts%5C+of%5C+U.%5C+macrophylla.%5C+It%5C+extended%5C+the%5C+structural%5C+variety%5C+of%5C+the%5C+known%5C+betaines.%5C+Macrophyllines%5C+A%5C+and%5C+B%5C+were%5C+a%5C+pair%5C+of%5C+isomers%5C+with%5C+acetonyl%5C+in%5C+skeleton%5C+compared%5C+with%5C+other%5C+analogues%2C%5C+and%5C+they%5C+were%5C+proved%5C+to%5C+be%5C+natural%5C+products.%5C+In%5C+addition%2C%5C+some%5C+compounds%5C+were%5C+evaluated%5C+for%5C+their%5C+cytotoxicity%5C+against%5C+five%5C+human%5C+cancer%5C+cell%5C+lines%5C+and%5C+vasodilative%5C+effects%5C+on%5C+KCl%5C-%5C%2Fphenylephrine%5C+%5C%28PE%5C%29%5C-induced%5C+contraction.%5C+As%5C+a%5C+result%2C%5C+corynantheidine%5C+exhibited%5C+cytotoxicity%5C+against%5C+HL%5C-60%5C+and%5C+SW480%5C+cells%5C+with%5C+IC50%5C+values%5C+of%5C+13.96%5C+and%5C+23.28%5C+%CE%BCM%2C%5C+respectively%5C%3B%5C+macrophylline%5C+A%2C%5C+isorhynchophylline%2C%5C+and%5C+dihydrocorynantheine%5C+showed%5C+strong%5C+inhibitory%5C+action%5C+on%5C+KCl%5C-%5C%2FPE%5C-induced%5C+contraction.%5C+It%5C+was%5C+noteworthy%5C+that%5C+dihydrocorynantheine%5C+almost%5C+inhibited%5C+completely%5C+PE%5C-induced%5C+contraction%5C+in%5C+rats%5C+thoracic%5C+aorta%5C+at%5C+30%5C+%CE%BCg%5C%2Fml.%5C+In%5C+contrast%5C+to%5C+the%5C+relatively%5C+smaller%5C+inhibitory%5C+effects%5C+of%5C+verapamil%5C+on%5C+PE%5C-induced%5C+contraction%5C+at%5C+3%5C+and%5C+10%5C+%CE%BCg%5C%2Fml%2C%5C+dihydrocorynantheine%5C+showed%5C+significant%5C+inhibitory%5C+actions.%5C+It%5C+was%5C+shown%5C+to%5C+be%5C+a%5C+potent%5C+vasorelaxant%5C+of%5C+aorta.%5C+Finally%2C%5C+a%5C+review%5C+titled%5C+advances%5C+of%5C+chemistry%5C+and%5C+pharmacology%5C+of%5C+the%5C+genus%5C+Uncaria%5C+is%5C+presented."},{"jsname":"The dissertation is comprised of six chapters, in which the chemical and bioactive constituents of nine plants, Melodinus henryi, Melodinus tenuicaudatus, Alstonia scholaris, Alstonia yunnanensis, Lycoris radiata, Lycoris aurea, Litsea cubeba, Poncirus trifoliata, and Pinus yunnanensis, have been phytochemically studied. A total of 267 compounds, including 57 new ones, were isolated from these species. Their structures were established on the basis of extensive spectroscopic methods and the combination with X-ray diffraction analysis. Of these compounds, monoterpenoid indole alkaloids are an important part, including several novel carbon skeletons, such as melohenines A and B and melotenine A, and a series of new and bioactive compounds, such as new bisindole alkaloids from two Melodinus species showing significant cytotoxicity against five human cancer cell lines. As a whole, the discovery of these compounds enriched the family of natural products, and the structural elucidation of these compounds enhanced our understanding towards the relationship among the monoterpenoid indole alkaloids types.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+dissertation%5C+is%5C+comprised%5C+of%5C+six%5C+chapters%2C%5C+in%5C+which%5C+the%5C+chemical%5C+and%5C+bioactive%5C+constituents%5C+of%5C+nine%5C+plants%2C%5C+Melodinus%5C+henryi%2C%5C+Melodinus%5C+tenuicaudatus%2C%5C+Alstonia%5C+scholaris%2C%5C+Alstonia%5C+yunnanensis%2C%5C+Lycoris%5C+radiata%2C%5C+Lycoris%5C+aurea%2C%5C+Litsea%5C+cubeba%2C%5C+Poncirus%5C+trifoliata%2C%5C+and%5C+Pinus%5C+yunnanensis%2C%5C+have%5C+been%5C+phytochemically%5C+studied.%5C+A%5C+total%5C+of%5C+267%5C+compounds%2C%5C+including%5C+57%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+these%5C+species.%5C+Their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+methods%5C+and%5C+the%5C+combination%5C+with%5C+X%5C-ray%5C+diffraction%5C+analysis.%5C+Of%5C+these%5C+compounds%2C%5C+monoterpenoid%5C+indole%5C+alkaloids%5C+are%5C+an%5C+important%5C+part%2C%5C+including%5C+several%5C+novel%5C+carbon%5C+skeletons%2C%5C+such%5C+as%5C+melohenines%5C+A%5C+and%5C+B%5C+and%5C+melotenine%5C+A%2C%5C+and%5C+a%5C+series%5C+of%5C+new%5C+and%5C+bioactive%5C+compounds%2C%5C+such%5C+as%5C+new%5C+bisindole%5C+alkaloids%5C+from%5C+two%5C+Melodinus%5C+species%5C+showing%5C+significant%5C+cytotoxicity%5C+against%5C+five%5C+human%5C+cancer%5C+cell%5C+lines.%5C+As%5C+a%5C+whole%2C%5C+the%5C+discovery%5C+of%5C+these%5C+compounds%5C+enriched%5C+the%5C+family%5C+of%5C+natural%5C+products%2C%5C+and%5C+the%5C+structural%5C+elucidation%5C+of%5C+these%5C+compounds%5C+enhanced%5C+our%5C+understanding%5C+towards%5C+the%5C+relationship%5C+among%5C+the%5C+monoterpenoid%5C+indole%5C+alkaloids%5C+types."},{"jsname":"The thesis has investagated on alkaloids in the fruits of three Daphniphyllum species Daphniphyllum longeracemosum, D. oldhami, and D. himalense, along with chemical compounds from leaves of Trichilia connaroides and Mitrephora maingayi. 83 compounds in total were acquired from those five plants and their structures were identified by organic spetra (NMR, MS, IR.), including two novel Daphniphyllum alkaloids, another three new ones, twelve new limonoids, a new steroids and a new acetogenin. Seventeen Daphniphyllum alkaloids were acquiered from Daphniphyllum longeracemosum, including two novel ones (Daphenylline and Longeramine) and another new alkaloid N-oxydaphnilongeranin C. Eighteen alkaloids were isolated from D. oldhamii, including two new alkaloids Daphnoldines A and B. Eleven alkaloids were afforded from D. himalense fruits.From Trichilia connaroides leaves, 22 compounds were afforded, including 12 new limonoids and a new steroid. 15 compounds were isolated from Mitrephora maingayi twigs and leaves, including a new annonaceous acetogenin.Furthermore, biological functions of Daphniphyllum alkaloids were initially seeked after based on their relation to squalene metabolism pathway. The alkaloids Longistylumphylline B and Paxdaphnine B were detected inhibtion against nAchR (a target protein for pesticide) from Drosophila. Furthermore, a phragmalin-type limonoid 30-acetyltrichagmalin F showed a moderate anti-PAF activity.In addition, squalene metabolism pathway along with its natual inhibitor and analogs were reviewed. The pathway was prospected as potential targets for antihyperlipoproteinemic drugs, pesticide, antifeedant or antifungal drugs.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+thesis%5C+has%5C+investagated%5C+on%5C+alkaloids%5C+in%5C+the%5C+fruits%5C+of%5C+three%5C+Daphniphyllum%5C+species%5C+Daphniphyllum%5C+longeracemosum%2C%5C+D.%5C+oldhami%2C%5C+and%5C+D.%5C+himalense%2C%5C+along%5C+with%5C+chemical%5C+compounds%5C+from%5C+leaves%5C+of%5C+Trichilia%5C+connaroides%5C+and%5C+Mitrephora%5C+maingayi.%5C+83%5C+compounds%5C+in%5C+total%5C+were%5C+acquired%5C+from%5C+those%5C+five%5C+plants%5C+and%5C+their%5C+structures%5C+were%5C+identified%5C+by%5C+organic%5C+spetra%5C+%5C%28NMR%2C%5C+MS%2C%5C+IR.%5C%29%2C%5C+including%5C+two%5C+novel%5C+Daphniphyllum%5C+alkaloids%2C%5C+another%5C+three%5C+new%5C+ones%2C%5C+twelve%5C+new%5C+limonoids%2C%5C+a%5C+new%5C+steroids%5C+and%5C+a%5C+new%5C+acetogenin.%5C+Seventeen%5C+Daphniphyllum%5C+alkaloids%5C+were%5C+acquiered%5C+from%5C+Daphniphyllum%5C+longeracemosum%2C%5C+including%5C+two%5C+novel%5C+ones%5C+%5C%28Daphenylline%5C+and%5C+Longeramine%5C%29%5C+and%5C+another%5C+new%5C+alkaloid%5C+N%5C-oxydaphnilongeranin%5C+C.%5C+Eighteen%5C+alkaloids%5C+were%5C+isolated%5C+from%5C+D.%5C+oldhamii%2C%5C+including%5C+two%5C+new%5C+alkaloids%5C+Daphnoldines%5C+A%5C+and%5C+B.%5C+Eleven%5C+alkaloids%5C+were%5C+afforded%5C+from%5C+D.%5C+himalense%5C+fruits.From%5C+Trichilia%5C+connaroides%5C+leaves%2C%5C+22%5C+compounds%5C+were%5C+afforded%2C%5C+including%5C+12%5C+new%5C+limonoids%5C+and%5C+a%5C+new%5C+steroid.%5C+15%5C+compounds%5C+were%5C+isolated%5C+from%5C+Mitrephora%5C+maingayi%5C+twigs%5C+and%5C+leaves%2C%5C+including%5C+a%5C+new%5C+annonaceous%5C+acetogenin.Furthermore%2C%5C+biological%5C+functions%5C+of%5C+Daphniphyllum%5C+alkaloids%5C+were%5C+initially%5C+seeked%5C+after%5C+based%5C+on%5C+their%5C+relation%5C+to%5C+squalene%5C+metabolism%5C+pathway.%5C+The%5C+alkaloids%5C+Longistylumphylline%5C+B%5C+and%5C+Paxdaphnine%5C+B%5C+were%5C+detected%5C+inhibtion%5C+against%5C+nAchR%5C+%5C%28a%5C+target%5C+protein%5C+for%5C+pesticide%5C%29%5C+from%5C+Drosophila.%5C+Furthermore%2C%5C+a%5C+phragmalin%5C-type%5C+limonoid%5C+30%5C-acetyltrichagmalin%5C+F%5C+showed%5C+a%5C+moderate%5C+anti%5C-PAF%5C+activity.In%5C+addition%2C%5C+squalene%5C+metabolism%5C+pathway%5C+along%5C+with%5C+its%5C+natual%5C+inhibitor%5C+and%5C+analogs%5C+were%5C+reviewed.%5C+The%5C+pathway%5C+was%5C+prospected%5C+as%5C+potential%5C+targets%5C+for%5C+antihyperlipoproteinemic%5C+drugs%2C%5C+pesticide%2C%5C+antifeedant%5C+or%5C+antifungal%5C+drugs."},{"jsname":"The thesis includes four chapters: Chapters 1 and 2 cover bioactive constituents of two traditional Chininese medicines of Ding-Zhi-Yuan prescription: Acorus tatarinowii Schott. and Poria cum Radix Pini. Chapter 3 introduces chemical components of flavonoids from the gum of Cerasus conradinae. In the last chapter, the research progress of Acorus was reviewed. As a result, 60 compounds were isolated from these plants, and eight of them were identified as new ones. Their structures were established on the basis of spectroscopic data. The types of these compounds include phenylpropanoids, lignans, flavonoids, sesquiterpenoids, alkaloids, and steroids.Chapter 1 introduced the chemical constitutents of Acorus tatarinowii Schott. Acorus tatarinowii Schott is a famous traditional Chinese medicine possessing anticonvulsive,spasmolytic, and neuroprotective effects. To study its pharmacological mechanism, 47 compounds, including 7 new ones, were isolated from this herb. AlphaScreen cAMP assay showed that six phenylpropanoids significantly increased cAMP level at the concentration of 50 µM. Two novel spiro-alkaloids inhibited high glucose-induced ROS production in mesangial cells. Besides, their anti-oxidant activities were dose-dependent and reached to the maximum at 10 μM and 50 μM, respectively.Chapter 2 introduced the chemical constitutents of Poria cum Radix Pin. Poria cum Radix Pini is the xylem of Poria cocos (Schw.) Wolf. As a traditional Chinese medicine, it has the effects for treatment of palpitation, forgettery, insomnia and other diseases. Chemical investigation about it resulted in 9 compounds and 1 compound was elucidated to be new. Chater 3 introduced the chemical constituents of flavonoids from the gum of Cerasus conradina.ere isolated from the gum ofCerasus conradinae. The fruits of Cerasus conradina were used to deal with heart failure, beriberi and edema. Because of frostibe, pest, and mechanical damage, Cerasus conradin excrete lots of gum in winter. To investigate the chemical constituents and the chemical defence function of the gum, 4 flavonoids with different structure types w. Chapter 4 reviewed the progress of the studies on chemistry and bioactivity of chemical constituents from Acorus","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThe%5C+thesis%5C+includes%5C+four%5C+chapters%5C%3A%5C+Chapters%5C+1%5C+and%5C+2%5C+cover%5C+bioactive%5C+constituents%5C+of%5C+two%5C+traditional%5C+Chininese%5C+medicines%5C+of%5C+Ding%5C-Zhi%5C-Yuan%5C+prescription%5C%3A%5C+Acorus%5C+tatarinowii%5C+Schott.%5C+and%5C+Poria%5C+cum%5C+Radix%5C+Pini.%5C+Chapter%5C+3%5C+introduces%5C+chemical%5C+components%5C+of%5C+flavonoids%5C+from%5C+the%5C+gum%5C+of%5C+Cerasus%5C+conradinae.%5C+In%5C+the%5C+last%5C+chapter%2C%5C+the%5C+research%5C+progress%5C+of%5C+Acorus%5C+was%5C+reviewed.%5C+As%5C+a%5C+result%2C%5C+60%5C+compounds%5C+were%5C+isolated%5C+from%5C+these%5C+plants%2C%5C+and%5C+eight%5C+of%5C+them%5C+were%5C+identified%5C+as%5C+new%5C+ones.%5C+Their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+spectroscopic%5C+data.%5C+The%5C+types%5C+of%5C+these%5C+compounds%5C+include%5C+phenylpropanoids%2C%5C+lignans%2C%5C+flavonoids%2C%5C+sesquiterpenoids%2C%5C+alkaloids%2C%5C+and%5C+steroids.Chapter%5C+1%5C+introduced%5C+the%5C+chemical%5C+constitutents%5C+of%5C+Acorus%5C+tatarinowii%5C+Schott.%5C+Acorus%5C+tatarinowii%5C+Schott%5C+is%5C+a%5C+famous%5C+traditional%5C+Chinese%5C+medicine%5C+possessing%5C+anticonvulsive%2Cspasmolytic%2C%5C+and%5C+neuroprotective%5C+effects.%5C+To%5C+study%5C+its%5C+pharmacological%5C+mechanism%2C%5C+47%5C+compounds%2C%5C+including%5C+7%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+this%5C+herb.%5C+AlphaScreen%5C+cAMP%5C+assay%5C+showed%5C+that%5C+six%5C+phenylpropanoids%5C+significantly%5C+increased%5C+cAMP%5C+level%5C+at%5C+the%5C+concentration%5C+of%5C+50%5C+%C2%B5M.%5C+Two%5C+novel%5C+spiro%5C-alkaloids%5C+inhibited%5C+high%5C+glucose%5C-induced%5C+ROS%5C+production%5C+in%5C+mesangial%5C+cells.%5C+Besides%2C%5C+their%5C+anti%5C-oxidant%5C+activities%5C+were%5C+dose%5C-dependent%5C+and%5C+reached%5C+to%5C+the%5C+maximum%5C+at%5C+10%5C+%CE%BCM%5C+and%5C+50%5C+%CE%BCM%2C%5C+respectively.Chapter%5C+2%5C+introduced%5C+the%5C+chemical%5C+constitutents%5C+of%5C+Poria%5C+cum%5C+Radix%5C+Pin.%5C+Poria%5C+cum%5C+Radix%5C+Pini%5C+is%5C+the%5C+xylem%5C+of%5C+Poria%5C+cocos%5C+%5C%28Schw.%5C%29%5C+Wolf.%5C+As%5C+a%5C+traditional%5C+Chinese%5C+medicine%2C%5C+it%5C+has%5C+the%5C+effects%5C+for%5C+treatment%5C+of%5C+palpitation%2C%5C+forgettery%2C%5C+insomnia%5C+and%5C+other%5C+diseases.%5C+Chemical%5C+investigation%5C+about%5C+it%5C+resulted%5C+in%5C+9%5C+compounds%5C+and%5C+1%5C+compound%5C+was%5C+elucidated%5C+to%5C+be%5C+new.%5C+Chater%5C+3%5C+introduced%5C+the%5C+chemical%5C+constituents%5C+of%5C+flavonoids%5C+from%5C+the%5C+gum%5C+of%5C+Cerasus%5C+conradina.ere%5C+isolated%5C+from%5C+the%5C+gum%5C+ofCerasus%5C+conradinae.%5C+The%5C+fruits%5C+of%5C+Cerasus%5C+conradina%5C+were%5C+used%5C+to%5C+deal%5C+with%5C+heart%5C+failure%2C%5C+beriberi%5C+and%5C+edema.%5C+Because%5C+of%5C+frostibe%2C%5C+pest%2C%5C+and%5C+mechanical%5C+damage%2C%5C+Cerasus%5C+conradin%5C+excrete%5C+lots%5C+of%5C+gum%5C+in%5C+winter.%5C+To%5C+investigate%5C+the%5C+chemical%5C+constituents%5C+and%5C+the%5C+chemical%5C+defence%5C+function%5C+of%5C+the%5C+gum%2C%5C+4%5C+flavonoids%5C+with%5C+different%5C+structure%5C+types%5C+w.%5C+Chapter%5C+4%5C+reviewed%5C+the%5C+progress%5C+of%5C+the%5C+studies%5C+on%5C+chemistry%5C+and%5C+bioactivity%5C+of%5C+chemical%5C+constituents%5C+from%5C+Acorus"},{"jsname":"This dissertation consists of four chapters. First chapter presents the result of investigation on chemical constituents and cytotoxic activities of Isodon rubescens var. rubescens f. lushanensis collected in Luanchuan prefecture of Henan province. Second chapter gives the research result on chemical constituents and cytotoxic activities of I leucophyllus (Dunn)Kudo collected in Shangri-La county, Yunnan province. The third chapter describes the same theme of I. scoparius C. Y. Wu et H. W. Li(Dunn)Kudocollected in Shangri-La county, Yunnan province. Chapter 4 is a review on the research progress of bicyclic and tricyclic diterpenoids in natural products, recently.80 compounds were isolated and identified from the above mentioned plants of the genus Isodon by means of chromatograhy methods and spectroscopic analyses, including 24 new compounds. Structural style of these compounds includes diterpenoids (ent-kaurane, ent-kaurane dimer, ent-abietane, ent-labdane, ent-clerodane), triterpenoids, steroids, flavonoids, and lignans. From ITwo diterpenoid dimmers with unique 16→17'' linkage were isolated and characterized from I leucophyllus for the first time. One ent-kaurane diterpenoids and one ent-clerodane dinorditerpenoid were isolated from Isodon scoparius. Especially, it was a powerful chemical evidence to clarify Isodon scoparius was one original species in the genus Isodon in view of biosynthetic pathway... rubescens var. rubescens f. lushanensis, two novel diterpenoids with unprecedented skeletons (one possessed a broken A ring and another with an expanded B ring) were isolated for the first time. Most diterpenoids were evaluated for their cytotoxic activity against several kinds of human tumor cell lines in vitro. Some of them exhibited significant activities and deserved to be studied thoroughly. With the preservation of bioactive center (α-mythelene cyclopentanone) in the structure, the diterpenoid which possesed a broken A ring still displayed potent cytotoxicity in HL-60 cell line. It could provide a helpful clue for simplifying the chemical structure of diterpenoids with significant cytotoxicity.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+consists%5C+of%5C+four%5C+chapters.%5C+First%5C+chapter%5C+presents%5C+the%5C+result%5C+of%5C+investigation%5C+on%5C+chemical%5C+constituents%5C+and%5C+cytotoxic%5C+activities%5C+of%5C+Isodon%5C+rubescens%5C+var.%5C+rubescens%5C+f.%5C+lushanensis%5C+collected%5C+in%5C+Luanchuan%5C+prefecture%5C+of%5C+Henan%5C+province.%5C+Second%5C+chapter%5C+gives%5C+the%5C+research%5C+result%5C+on%5C+chemical%5C+constituents%5C+and%5C+cytotoxic%5C+activities%5C+of%5C+I%5C+leucophyllus%5C+%5C%28Dunn%5C%29Kudo%5C+collected%5C+in%5C+Shangri%5C-La%5C+county%2C%5C+Yunnan%5C+province.%5C+The%5C+third%5C+chapter%5C+describes%5C+the%5C+same%5C+theme%5C+of%5C+I.%5C+scoparius%5C+C.%5C+Y.%5C+Wu%5C+et%5C+H.%5C+W.%5C+Li%5C%28Dunn%5C%29Kudocollected%5C+in%5C+Shangri%5C-La%5C+county%2C%5C+Yunnan%5C+province.%5C+Chapter%5C+4%5C+is%5C+a%5C+review%5C+on%5C+the%5C+research%5C+progress%5C+of%5C+bicyclic%5C+and%5C+tricyclic%5C+diterpenoids%5C+in%5C+natural%5C+products%2C%5C+recently.80%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+above%5C+mentioned%5C+plants%5C+of%5C+the%5C+genus%5C+Isodon%5C+by%5C+means%5C+of%5C+chromatograhy%5C+methods%5C+and%5C+spectroscopic%5C+analyses%2C%5C+including%5C+24%5C+new%5C+compounds.%5C+Structural%5C+style%5C+of%5C+these%5C+compounds%5C+includes%5C+diterpenoids%5C+%5C%28ent%5C-kaurane%2C%5C+ent%5C-kaurane%5C+dimer%2C%5C+ent%5C-abietane%2C%5C+ent%5C-labdane%2C%5C+ent%5C-clerodane%5C%29%2C%5C+triterpenoids%2C%5C+steroids%2C%5C+flavonoids%2C%5C+and%5C+lignans.%5C+From%5C+ITwo%5C+diterpenoid%5C+dimmers%5C+with%5C+unique%5C+16%E2%86%9217%27%27%5C+linkage%5C+were%5C+isolated%5C+and%5C+characterized%5C+from%5C+I%5C+leucophyllus%5C+for%5C+the%5C+first%5C+time.%5C+One%5C+ent%5C-kaurane%5C+diterpenoids%5C+and%5C+one%5C+ent%5C-clerodane%5C+dinorditerpenoid%5C+were%5C+isolated%5C+from%5C+Isodon%5C+scoparius.%5C+Especially%2C%5C+it%5C+was%5C+a%5C+powerful%5C+chemical%5C+evidence%5C+to%5C+clarify%5C+Isodon%5C+scoparius%5C+was%5C+one%5C+original%5C+species%5C+in%5C+the%5C+genus%5C+Isodon%5C+in%5C+view%5C+of%5C+biosynthetic%5C+pathway...%5C+rubescens%5C+var.%5C+rubescens%5C+f.%5C+lushanensis%2C%5C+two%5C+novel%5C+diterpenoids%5C+with%5C+unprecedented%5C+skeletons%5C+%5C%28one%5C+possessed%5C+a%5C+broken%5C+A%5C+ring%5C+and%5C+another%5C+with%5C+an%5C+expanded%5C+B%5C+ring%5C%29%5C+were%5C+isolated%5C+for%5C+the%5C+first%5C+time.%5C+Most%5C+diterpenoids%5C+were%5C+evaluated%5C+for%5C+their%5C+cytotoxic%5C+activity%5C+against%5C+several%5C+kinds%5C+of%5C+human%5C+tumor%5C+cell%5C+lines%5C+in%5C+vitro.%5C+Some%5C+of%5C+them%5C+exhibited%5C+significant%5C+activities%5C+and%5C+deserved%5C+to%5C+be%5C+studied%5C+thoroughly.%5C+With%5C+the%5C+preservation%5C+of%5C+bioactive%5C+center%5C+%5C%28%CE%B1%5C-mythelene%5C+cyclopentanone%5C%29%5C+in%5C+the%5C+structure%2C%5C+the%5C+diterpenoid%5C+which%5C+possesed%5C+a%5C+broken%5C+A%5C+ring%5C+still%5C+displayed%5C+potent%5C+cytotoxicity%5C+in%5C+HL%5C-60%5C+cell%5C+line.%5C+It%5C+could%5C+provide%5C+a%5C+helpful%5C+clue%5C+for%5C+simplifying%5C+the%5C+chemical%5C+structure%5C+of%5C+diterpenoids%5C+with%5C+significant%5C+cytotoxicity."},{"jsname":"This dissertation is composed of five chapters, in which the chemical constituents of four medicinal plants, Hypoxis aurea Lour., Albizia mollis (Wall.) Boiv., Dobinea delavayi (Baill.) Baill. and Poria cococs (Schw.) Wolf, which are belonged to families of Hypoxidaceae, Leguminosae, Polyporaceae and Podoaceae, respectively, have been phytochemically studied. Chapter 5 reviews the chemical and bioactivities progresses of Albizia and Hypoxis genera. 79 compounds, including 12 new ones, were isolated from the above mentioned four species. All of the components were separated by column chromatography (siliga gel, sephadex LH-20, RP-18, RP-8 and half-preparation HPLC) and identified on the basis of extensive spectroscopic methods. The type of all compounds include phenolic glycosides, triterpenoids (lanosterol, oleanane type), diterpenoids (ent-kaurane type), eudesmane sesquiterpenes, lignanoids, ceramides, flavones, fatty acid (ester). We put forward a proposal that Albizia and Hypoxis genera should belong to Hypoxidaceae and be independent from Amaryllidaceae. Parts of compounds have been or being texted for antineoplastic, antidepressant.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+is%5C+composed%5C+of%5C+five%5C+chapters%2C%5C+in%5C+which%5C+the%5C+chemical%5C+constituents%5C+of%5C+four%5C+medicinal%5C+plants%2C%5C+Hypoxis%5C+aurea%5C+Lour.%2C%5C+Albizia%5C+mollis%5C+%5C%28Wall.%5C%29%5C+Boiv.%2C%5C+Dobinea%5C+delavayi%5C+%5C%28Baill.%5C%29%5C+Baill.%5C+and%5C+Poria%5C+cococs%5C+%5C%28Schw.%5C%29%5C+Wolf%2C%5C+which%5C+are%5C+belonged%5C+to%5C+families%5C+of%5C+Hypoxidaceae%2C%5C+Leguminosae%2C%5C+Polyporaceae%5C+and%5C+Podoaceae%2C%5C+respectively%2C%5C+have%5C+been%5C+phytochemically%5C+studied.%5C+Chapter%5C+5%5C+reviews%5C+the%5C+chemical%5C+and%5C+bioactivities%5C+progresses%5C+of%5C+Albizia%5C+and%5C+Hypoxis%5C+genera.%5C+79%5C+compounds%2C%5C+including%5C+12%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+the%5C+above%5C+mentioned%5C+four%5C+species.%5C+All%5C+of%5C+the%5C+components%5C+were%5C+separated%5C+by%5C+column%5C+chromatography%5C+%5C%28siliga%5C+gel%2C%5C+sephadex%5C+LH%5C-20%2C%5C+RP%5C-18%2C%5C+RP%5C-8%5C+and%5C+half%5C-preparation%5C+HPLC%5C%29%5C+and%5C+identified%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+methods.%5C+The%5C+type%5C+of%5C+all%5C+compounds%5C+include%5C+phenolic%5C+glycosides%2C%5C+triterpenoids%5C+%5C%28lanosterol%2C%5C+oleanane%5C+type%5C%29%2C%5C+diterpenoids%5C+%5C%28ent%5C-kaurane%5C+type%5C%29%2C%5C+eudesmane%5C+sesquiterpenes%2C%5C+lignanoids%2C%5C+ceramides%2C%5C+flavones%2C%5C+fatty%5C+acid%5C+%5C%28ester%5C%29.%5C+We%5C+put%5C+forward%5C+a%5C+proposal%5C+that%5C+Albizia%5C+and%5C+Hypoxis%5C+genera%5C+should%5C+belong%5C+to%5C+Hypoxidaceae%5C+and%5C+be%5C+independent%5C+from%5C+Amaryllidaceae.%5C+Parts%5C+of%5C+compounds%5C+have%5C+been%5C+or%5C+being%5C+texted%5C+for%5C+antineoplastic%2C%5C+antidepressant."},{"jsname":"This dissertation is composed of four chapters, in which the chemical constituents of three medicinal plants, Abrus precatorius L., Echinops ritro L., and Saussurea laniceps Hand-Mazz. have been phytochemically studied. 150 compounds, including 10 new ones, were isolated from above mentioned three species. Their structures were established on the basis of extensive spectroscopic methods in conjunction with single-crystal X-ray diffraction analysis and computational methods. Chapter 4 is a review about the chemical constituentsand bioactivities from the plants genus Echinops of the family Compositae. These compounds include monoterpenes, sesquiterpenes (including guaiane and eudesmane mainly), triterpenoids, alkaloids, thiophenes, coumarins, steroids, lignans, flavones and its glycosides. A series of guaiane and eudesmane type sesquiterpenes have been isolated from Echinops ritro L., which is the first time in Echinops species. 21 substituted thiophenes (including 4 new ones) have been isolated from it. Some of them exhibited significant anti-microbial activity. As well as, one novel sulf-polyacetylene ester was isolated from Echinops ritro L.. The computational prediction of optical rotation values and 13C NMR chemical shift was attempted to elucidate structure of natural products. A series of sesquiterpenes have been isolated from Saussurea laniceps Hand-Mazz.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+dissertation%5C+is%5C+composed%5C+of%5C+four%5C+chapters%2C%5C+in%5C+which%5C+the%5C+chemical%5C+constituents%5C+of%5C+three%5C+medicinal%5C+plants%2C%5C+Abrus%5C+precatorius%5C+L.%2C%5C+Echinops%5C+ritro%5C+L.%2C%5C+and%5C+Saussurea%5C+laniceps%5C+Hand%5C-Mazz.%5C+have%5C+been%5C+phytochemically%5C+studied.%5C+150%5C+compounds%2C%5C+including%5C+10%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+above%5C+mentioned%5C+three%5C+species.%5C+Their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+methods%5C+in%5C+conjunction%5C+with%5C+single%5C-crystal%5C+X%5C-ray%5C+diffraction%5C+analysis%5C+and%5C+computational%5C+methods.%5C+Chapter%5C+4%5C+is%5C+a%5C+review%5C+about%5C+the%5C+chemical%5C+constituentsand%5C+bioactivities%5C+from%5C+the%5C+plants%5C+genus%5C+Echinops%5C+of%5C+the%5C+family%5C+Compositae.%5C+These%5C+compounds%5C+include%5C+monoterpenes%2C%5C+sesquiterpenes%5C+%5C%28including%5C+guaiane%5C+and%5C+eudesmane%5C+mainly%5C%29%2C%5C+triterpenoids%2C%5C+alkaloids%2C%5C+thiophenes%2C%5C+coumarins%2C%5C+steroids%2C%5C+lignans%2C%5C+flavones%5C+and%5C+its%5C+glycosides.%5C+A%5C+series%5C+of%5C+guaiane%5C+and%5C+eudesmane%5C+type%5C+sesquiterpenes%5C+have%5C+been%5C+isolated%5C+from%5C+Echinops%5C+ritro%5C+L.%2C%5C+which%5C+is%5C+the%5C+first%5C+time%5C+in%5C+Echinops%5C+species.%5C+21%5C+substituted%5C+thiophenes%5C+%5C%28including%5C+4%5C+new%5C+ones%5C%29%5C+have%5C+been%5C+isolated%5C+from%5C+it.%5C+Some%5C+of%5C+them%5C+exhibited%5C+significant%5C+anti%5C-microbial%5C+activity.%5C+As%5C+well%5C+as%2C%5C+one%5C+novel%5C+sulf%5C-polyacetylene%5C+ester%5C+was%5C+isolated%5C+from%5C+Echinops%5C+ritro%5C+L..%5C+The%5C+computational%5C+prediction%5C+of%5C+optical%5C+rotation%5C+values%5C+and%5C+13C%5C+NMR%5C+chemical%5C+shift%5C+was%5C+attempted%5C+to%5C+elucidate%5C+structure%5C+of%5C+natural%5C+products.%5C+A%5C+series%5C+of%5C+sesquiterpenes%5C+have%5C+been%5C+isolated%5C+from%5C+Saussurea%5C+laniceps%5C+Hand%5C-Mazz."},{"jsname":"This thesis consists of three chapters. Chapter 1 described the chemical constituents of Excoecaria acerifolia Didr., and their bioactivities. In the second chapter, we presented the results of the isolation and identification of chemical constituents of Verbascum thapsus L., and their bioactivities. In the last chapter, we reviewed all the chemical constituents from the genus Excoecaria based on revelant literatures since 1971. As a result, 42 compounds were isolated from the above-metioned two medicinal plants, including 2 new compounds, and their structures were established on the basis of spectral methods including 1D- and 2D NMR, MS, HR-MS, IR spectra, The identified 42 compounds possess various types, including flavonoid, monoterpene, sesquiterpenoids, iridoid, diterpene, triterpenoid, saponin, coumarin, alkaloid and so on. Chapter 1 Chemical Constituents and Bioactivity of Excoecaria acerifolia, Excoecaria acerifolia Didr., a member of the family Euphorbiaceae. In our present study, 21 compounds including a new one were isolated and identified. Compound 9 showed bioactivity in antiangiogenic effect. Additionally, compounds 4, 6, 10 and 11 showed bioactivity in inhibiting the growth of A549 lung cancer cells, and compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells. Chapter 2 Chemical Constituents and Bioactivity of Verbascum Thapsus, Verbascum thapsus L. belonging to the family Scrophulariaceae. In our current study, 21 compounds were isolated and identified, including a new compound. Compounds 17 and 20 showed bioactivity in inhibiting the growth of A549 lung cancer cells, and apoptosis-inducing effects. Chapter 3 Chemical Constituents of Plants from the Genus Excoecaria, This review covers 50 literatures published from 1971 to 2010 on the chemical constituents of the plants from the genus Excoecaria (Euphorbiaceae).","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+thesis%5C+consists%5C+of%5C+three%5C+chapters.%5C+Chapter%5C+1%5C+described%5C+the%5C+chemical%5C+constituents%5C+of%5C+Excoecaria%5C+acerifolia%5C+Didr.%2C%5C+and%5C+their%5C+bioactivities.%5C+In%5C+the%5C+second%5C+chapter%2C%5C+we%5C+presented%5C+the%5C+results%5C+of%5C+the%5C+isolation%5C+and%5C+identification%5C+of%5C+chemical%5C+constituents%5C+of%5C+Verbascum%5C+thapsus%5C+L.%2C%5C+and%5C+their%5C+bioactivities.%5C+In%5C+the%5C+last%5C+chapter%2C%5C+we%5C+reviewed%5C+all%5C+the%5C+chemical%5C+constituents%5C+from%5C+the%5C+genus%5C+Excoecaria%5C+based%5C+on%5C+revelant%5C+literatures%5C+since%5C+1971.%5C+As%5C+a%5C+result%2C%5C+42%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+above%5C-metioned%5C+two%5C+medicinal%5C+plants%2C%5C+including%5C+2%5C+new%5C+compounds%2C%5C+and%5C+their%5C+structures%5C+were%5C+established%5C+on%5C+the%5C+basis%5C+of%5C+spectral%5C+methods%5C+including%5C+1D%5C-%5C+and%5C+2D%5C+NMR%2C%5C+MS%2C%5C+HR%5C-MS%2C%5C+IR%5C+spectra%2C%5C+The%5C+identified%5C+42%5C+compounds%5C+possess%5C+various%5C+types%2C%5C+including%5C+flavonoid%2C%5C+monoterpene%2C%5C+sesquiterpenoids%2C%5C+iridoid%2C%5C+diterpene%2C%5C+triterpenoid%2C%5C+saponin%2C%5C+coumarin%2C%5C+alkaloid%5C+and%5C+so%5C+on.%5C+Chapter%5C+1%5C+Chemical%5C+Constituents%5C+and%5C+Bioactivity%5C+of%5C+Excoecaria%5C+acerifolia%2C%5C+Excoecaria%5C+acerifolia%5C+Didr.%2C%5C+a%5C+member%5C+of%5C+the%5C+family%5C+Euphorbiaceae.%5C+In%5C+our%5C+present%5C+study%2C%5C+21%5C+compounds%5C+including%5C+a%5C+new%5C+one%5C+were%5C+isolated%5C+and%5C+identified.%5C+Compound%5C+9%5C+showed%5C+bioactivity%5C+in%5C+antiangiogenic%5C+effect.%5C+Additionally%2C%5C+compounds%5C+4%2C%5C+6%2C%5C+10%5C+and%5C+11%5C+showed%5C+bioactivity%5C+in%5C+inhibiting%5C+the%5C+growth%5C+of%5C+A549%5C+lung%5C+cancer%5C+cells%2C%5C+and%5C+compound%5C+10%5C+also%5C+showed%5C+apoptosis%5C-inducing%5C+effects%5C+on%5C+A549%5C+lung%5C+cancer%5C+cells.%5C+Chapter%5C+2%5C+Chemical%5C+Constituents%5C+and%5C+Bioactivity%5C+of%5C+Verbascum%5C+Thapsus%2C%5C+Verbascum%5C+thapsus%5C+L.%5C+belonging%5C+to%5C+the%5C+family%5C+Scrophulariaceae.%5C+In%5C+our%5C+current%5C+study%2C%5C+21%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%2C%5C+including%5C+a%5C+new%5C+compound.%5C+Compounds%5C+17%5C+and%5C+20%5C+showed%5C+bioactivity%5C+in%5C+inhibiting%5C+the%5C+growth%5C+of%5C+A549%5C+lung%5C+cancer%5C+cells%2C%5C+and%5C+apoptosis%5C-inducing%5C+effects.%5C+Chapter%5C+3%5C+Chemical%5C+Constituents%5C+of%5C+Plants%5C+from%5C+the%5C+Genus%5C+Excoecaria%2C%5C+This%5C+review%5C+covers%5C+50%5C+literatures%5C+published%5C+from%5C+1971%5C+to%5C+2010%5C+on%5C+the%5C+chemical%5C+constituents%5C+of%5C+the%5C+plants%5C+from%5C+the%5C+genus%5C+Excoecaria%5C+%5C%28Euphorbiaceae%5C%29."},{"jsname":"This thesis deals with the research work on the chemical constituents of Camellia taliensis, Camellia pachyandra, Camellia oleifera, Metapanax delavayi , Pu-er tea (Camellia sinensis var. assamica) and one of the dominant microorganisms in the post-fermentation of Pu-er tea, Aspergillus japonicus var. japonicus through the systematic phytochemical methods. By the modern techniques of chromatography, spectroscopy along with chemical degradation methods, 107 compounds were isolated and identified by MS, 1D and 2D NMR spectra along with other spectroscopic method along with chemical degradation. The compounds include hydrolysable tannins, flavan-3ols, flavonoid glycosides, triterpene glycosides, simple phenolics and so on, most of which were evaluated by antioxidant or anti-viral activities. Meantime, the HPLC analytical methods were applied to compare the chemical constituents of C. taliensis and C. pachyandra with with those of the cultivated tea, C. sinensis var. assamica. Above all, the detection methods were established for the analysis of tea polyphenols, tea polysaccharides, caffeine and the main polyphenolic constituents in tea. And finally, the progress of the research work on Pu-er tea was reviewed.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+thesis%5C+deals%5C+with%5C+the%5C+research%5C+work%5C+on%5C+the%5C+chemical%5C+constituents%5C+of%5C+Camellia%5C+taliensis%2C%5C+Camellia%5C+pachyandra%2C%5C+Camellia%5C+oleifera%2C%5C+Metapanax%5C+delavayi%5C+%2C%5C+Pu%5C-er%5C+tea%5C+%5C%28Camellia%5C+sinensis%5C+var.%5C+assamica%5C%29%5C+and%5C+one%5C+of%5C+the%5C+dominant%5C+microorganisms%5C+in%5C+the%5C+post%5C-fermentation%5C+of%5C+Pu%5C-er%5C+tea%2C%5C+Aspergillus%5C+japonicus%5C+var.%5C+japonicus%5C+through%5C+the%5C+systematic%5C+phytochemical%5C+methods.%5C+By%5C+the%5C+modern%5C+techniques%5C+of%5C+chromatography%2C%5C+spectroscopy%5C+along%5C+with%5C+chemical%5C+degradation%5C+methods%2C%5C+107%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%5C+by%5C+MS%2C%5C+1D%5C+and%5C+2D%5C+NMR%5C+spectra%5C+along%5C+with%5C+other%5C+spectroscopic%5C+method%5C+along%5C+with%5C+chemical%5C+degradation.%5C+The%5C+compounds%5C+include%5C+hydrolysable%5C+tannins%2C%5C+flavan%5C-3ols%2C%5C+flavonoid%5C+glycosides%2C%5C+triterpene%5C+glycosides%2C%5C+simple%5C+phenolics%5C+and%5C+so%5C+on%2C%5C+most%5C+of%5C+which%5C+were%5C+evaluated%5C+by%5C+antioxidant%5C+or%5C+anti%5C-viral%5C+activities.%5C+Meantime%2C%5C+the%5C+HPLC%5C+analytical%5C+methods%5C+were%5C+applied%5C+to%5C+compare%5C+the%5C+chemical%5C+constituents%5C+of%5C+C.%5C+taliensis%5C+and%5C+C.%5C+pachyandra%5C+with%5C+with%5C+those%5C+of%5C+the%5C+cultivated%5C+tea%2C%5C+C.%5C+sinensis%5C+var.%5C+assamica.%5C+Above%5C+all%2C%5C+the%5C+detection%5C+methods%5C+were%5C+established%5C+for%5C+the%5C+analysis%5C+of%5C+tea%5C+polyphenols%2C%5C+tea%5C+polysaccharides%2C%5C+caffeine%5C+and%5C+the%5C+main%5C+polyphenolic%5C+constituents%5C+in%5C+tea.%5C+And%5C+finally%2C%5C+the%5C+progress%5C+of%5C+the%5C+research%5C+work%5C+on%5C+Pu%5C-er%5C+tea%5C+was%5C+reviewed."},{"jsname":"This thesis includes two parts: the investigation of medicinal plants in the communities of De''ang people, and the phytochemical studies on three medicinal plants used by the De''ang people traditionally. The De''ang people is an old indigenous minority in China. Most De''ang people live in the Southwest of Yunan Province. They have accumulated abundant traditional knowledge about utilization of medicinal plants in their long-time live and produce. However, without written script of their own and with the influence of alien cultures, their indigenous knowledge is facing the risk of being assimilated or extinct. We carried out an ethnoparmacological investigation of medicinal plants in De''ang communities. It has been found that 92 species were highly valuable for medicinal uses including heat-clearing and detoxication, anti-inflammatory pain, bone fracture and injury, relieving rigidity of muscles and promoting blood circulation, snake bite and so on. Of the 92 plants recorded, 23 species were newly recorded for the De''ang people, and new medicinal properties of one plant species (Tacca chantrieri) was the first record too. In order to know well of the medicinal properties of traditional medicinal plants used by the De''ang people, we selected three plants (Piper boehmeriaefolium, Remusatia vivipara and Pilea cavaleriei subsp. crenata) for the chemical constituents research. Forty-six compounds including 13 new ones were isolated from the above mentioned folk medicinal plants. The types of these compounds involved amide alkaloids, lignans, phenylpropanoids, terpenoids, flavanoids and so on. In addition, some of the isolates were tested for their bioactivities. Thirty compounds, including 8 new ones, were isolated from the whole plant of Piper boehmeriaefolium (Piperaceae). The compounds from the plant mainly belonged to the alkaloids of amides. A new phenylpropanoid glucoside, caffeyl alcohol-3-O-b-d-glucopyranoside, together with nine known compounds, was isolated from the dry corms of Remusatia vivipara (Araceae). The structure of the new compound was determined by the spectroscopic method and acidic hydrolysis. The compounds from the plant mainly belonged to phenlpropanoids, neolignans, steroid saponin, triterpenoid saponin and amides. All compounds were isolated from the genus Remusatia for the first time. Three new humulane-type sesquiterpenes, and a new copaborneol derivative, , together with two known compounds have been isolated from the whole plant of Pilea cavaleriei subsp. crenata (Urticaceae). All compounds were isolated from the genus Pilea for the first time.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+thesis%5C+includes%5C+two%5C+parts%5C%3A%5C+the%5C+investigation%5C+of%5C+medicinal%5C+plants%5C+in%5C+the%5C+communities%5C+of%5C+De%27%27ang%5C+people%2C%5C+and%5C+the%5C+phytochemical%5C+studies%5C+on%5C+three%5C+medicinal%5C+plants%5C+used%5C+by%5C+the%5C+De%27%27ang%5C+people%5C+traditionally.%5C+The%5C+De%27%27ang%5C+people%5C+is%5C+an%5C+old%5C+indigenous%5C+minority%5C+in%5C+China.%5C+Most%5C+De%27%27ang%5C+people%5C+live%5C+in%5C+the%5C+Southwest%5C+of%5C+Yunan%5C+Province.%5C+They%5C+have%5C+accumulated%5C+abundant%5C+traditional%5C+knowledge%5C+about%5C+utilization%5C+of%5C+medicinal%5C+plants%5C+in%5C+their%5C+long%5C-time%5C+live%5C+and%5C+produce.%5C+However%2C%5C+without%5C+written%5C+script%5C+of%5C+their%5C+own%5C+and%5C+with%5C+the%5C+influence%5C+of%5C+alien%5C+cultures%2C%5C+their%5C+indigenous%5C+knowledge%5C+is%5C+facing%5C+the%5C+risk%5C+of%5C+being%5C+assimilated%5C+or%5C+extinct.%5C+We%5C+carried%5C+out%5C+an%5C+ethnoparmacological%5C+investigation%5C+of%5C+medicinal%5C+plants%5C+in%5C+De%27%27ang%5C+communities.%5C+It%5C+has%5C+been%5C+found%5C+that%5C+92%5C+species%5C+were%5C+highly%5C+valuable%5C+for%5C+medicinal%5C+uses%5C+including%5C+heat%5C-clearing%5C+and%5C+detoxication%2C%5C+anti%5C-inflammatory%5C+pain%2C%5C+bone%5C+fracture%5C+and%5C+injury%2C%5C+relieving%5C+rigidity%5C+of%5C+muscles%5C+and%5C+promoting%5C+blood%5C+circulation%2C%5C+snake%5C+bite%5C+and%5C+so%5C+on.%5C+Of%5C+the%5C+92%5C+plants%5C+recorded%2C%5C+23%5C+species%5C+were%5C+newly%5C+recorded%5C+for%5C+the%5C+De%27%27ang%5C+people%2C%5C+and%5C+new%5C+medicinal%5C+properties%5C+of%5C+one%5C+plant%5C+species%5C+%5C%28Tacca%5C+chantrieri%5C%29%5C+was%5C+the%5C+first%5C+record%5C+too.%5C+In%5C+order%5C+to%5C+know%5C+well%5C+of%5C+the%5C+medicinal%5C+properties%5C+of%5C+traditional%5C+medicinal%5C+plants%5C+used%5C+by%5C+the%5C+De%27%27ang%5C+people%2C%5C+we%5C+selected%5C+three%5C+plants%5C+%5C%28Piper%5C+boehmeriaefolium%2C%5C+Remusatia%5C+vivipara%5C+and%5C+Pilea%5C+cavaleriei%5C+subsp.%5C+crenata%5C%29%5C+for%5C+the%5C+chemical%5C+constituents%5C+research.%5C+Forty%5C-six%5C+compounds%5C+including%5C+13%5C+new%5C+ones%5C+were%5C+isolated%5C+from%5C+the%5C+above%5C+mentioned%5C+folk%5C+medicinal%5C+plants.%5C+The%5C+types%5C+of%5C+these%5C+compounds%5C+involved%5C+amide%5C+alkaloids%2C%5C+lignans%2C%5C+phenylpropanoids%2C%5C+terpenoids%2C%5C+flavanoids%5C+and%5C+so%5C+on.%5C+In%5C+addition%2C%5C+some%5C+of%5C+the%5C+isolates%5C+were%5C+tested%5C+for%5C+their%5C+bioactivities.%5C+Thirty%5C+compounds%2C%5C+including%5C+8%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+from%5C+the%5C+whole%5C+plant%5C+of%5C+Piper%5C+boehmeriaefolium%5C+%5C%28Piperaceae%5C%29.%5C+The%5C+compounds%5C+from%5C+the%5C+plant%5C+mainly%5C+belonged%5C+to%5C+the%5C+alkaloids%5C+of%5C+amides.%5C+A%5C+new%5C+phenylpropanoid%5C+glucoside%2C%5C+caffeyl%5C+alcohol%5C-3%5C-O%5C-b%5C-d%5C-glucopyranoside%2C%5C+together%5C+with%5C+nine%5C+known%5C+compounds%2C%5C+was%5C+isolated%5C+from%5C+the%5C+dry%5C+corms%5C+of%5C+Remusatia%5C+vivipara%5C+%5C%28Araceae%5C%29.%5C+The%5C+structure%5C+of%5C+the%5C+new%5C+compound%5C+was%5C+determined%5C+by%5C+the%5C+spectroscopic%5C+method%5C+and%5C+acidic%5C+hydrolysis.%5C+The%5C+compounds%5C+from%5C+the%5C+plant%5C+mainly%5C+belonged%5C+to%5C+phenlpropanoids%2C%5C+neolignans%2C%5C+steroid%5C+saponin%2C%5C+triterpenoid%5C+saponin%5C+and%5C+amides.%5C+All%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+genus%5C+Remusatia%5C+for%5C+the%5C+first%5C+time.%5C+Three%5C+new%5C+humulane%5C-type%5C+sesquiterpenes%2C%5C+and%5C+a%5C+new%5C+copaborneol%5C+derivative%2C%5C+%2C%5C+together%5C+with%5C+two%5C+known%5C+compounds%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+whole%5C+plant%5C+of%5C+Pilea%5C+cavaleriei%5C+subsp.%5C+crenata%5C+%5C%28Urticaceae%5C%29.%5C+All%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+genus%5C+Pilea%5C+for%5C+the%5C+first%5C+time."},{"jsname":"This thesis is composed of five chapters.The first chapter describes chemical constituents from the leaves and twigs of Elaeagnus lanceolata. Nineteen compounds were isolated and identified, incl-uding a new compound, isoamericanol B (1), and 18 known compounds, 6-hy-droxy-3, 4-dihydro-1-oxo-β-carboline (2), 2α-hydroxy-ursolic acid (3), 2α, 23-dih-ydroxy-ursolic acid (4), maslinic acid (5), vomifoliol (6), roseoside (7), syringa-resinol (8), clemaphenol A (9), japonica acid (10), lutein (11), trilobatin (12), 3-phenyl-1-(2'', 6''-dihydroxy-phenyl-4''-O-β-D-glucopyranosyl)-1-propanone (13), n-aringenin-7-O-β-D-glucopyranoside (14), vitexin (8-C-β-D-glucopyranosyl apigeni-n) (15), 7-O-β-D-glucopyranosyl chrysin (16), isorhamnetin 3-O-α-L-rhamnopyra-nosyl-7-O-β-D-glucopyranoside (17), kaempferol-3-O-β-D-glucopyranoside (18) a-nd kaempferol-3-O-β-D-(6''''-O-trans-p-coumaroyl) glucopyranoside (19). Compou-nds 2-17 were isolated from this plant for the first time.The second chapter describes chemical constituents from the leaves and twi-gs of Gardenia sootepensis. Seven compounds were isolated and identified, incl-uding oleanolic acid (1), coronalolide methyl ester (2), sootepin D (3), sootepi-n F (4), sootepin G (5), sootepin H (6) and sootepin I (7). 4-7 are new com-pounds.The third chapter describes chemical constituents from the fruits of Gardeni-a jasminoides. Eight compounds were isolated. These compounds were identifi-ed to be jasminodiol (1), syringaresinol (2), methyl α-D-fructofuranoside (3), cl-ethric acid (4), geniposide(5), diethylhexylphthalate (6), 5'', 7''-octadecadienoic acid, 2, 3-dihydroxypropyl ester (7) and ursolic acid (8).The forth chapter describes chemical constituents from the root of Iris pseu-dacorus. Four compounds were isolated and identified, including 5α, 8α-epidio-xyergosta-6, 22-dien-3β-ol (1), ayamenin B (2), 2-hydroxy-benzoic acid (3) and β-sitosterol (4).The fifth chapter reviewed the recent progress on seco-cycloartane triterpene studies, their structure types, distribution, and biological activities were described.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E9%25BB%2584%25E9%2585%25AE%25E7%25B1%25BB&order=desc&&fq=dc.project.title_filter%3AThis%5C+thesis%5C+is%5C+composed%5C+of%5C+five%5C+chapters.The%5C+first%5C+chapter%5C+describes%5C+chemical%5C+constituents%5C+from%5C+the%5C+leaves%5C+and%5C+twigs%5C+of%5C+Elaeagnus%5C+lanceolata.%5C+Nineteen%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%2C%5C+incl%5C-uding%5C+a%5C+new%5C+compound%2C%5C+isoamericanol%5C+B%5C+%5C%281%5C%29%2C%5C+and%5C+18%5C+known%5C+compounds%2C%5C+6%5C-hy%5C-droxy%5C-3%2C%5C+4%5C-dihydro%5C-1%5C-oxo%5C-%CE%B2%5C-carboline%5C+%5C%282%5C%29%2C%5C+2%CE%B1%5C-hydroxy%5C-ursolic%5C+acid%5C+%5C%283%5C%29%2C%5C+2%CE%B1%2C%5C+23%5C-dih%5C-ydroxy%5C-ursolic%5C+acid%5C+%5C%284%5C%29%2C%5C+maslinic%5C+acid%5C+%5C%285%5C%29%2C%5C+vomifoliol%5C+%5C%286%5C%29%2C%5C+roseoside%5C+%5C%287%5C%29%2C%5C+syringa%5C-resinol%5C+%5C%288%5C%29%2C%5C+clemaphenol%5C+A%5C+%5C%289%5C%29%2C%5C+japonica%5C+acid%5C+%5C%2810%5C%29%2C%5C+lutein%5C+%5C%2811%5C%29%2C%5C+trilobatin%5C+%5C%2812%5C%29%2C%5C+3%5C-phenyl%5C-1%5C-%5C%282%27%27%2C%5C+6%27%27%5C-dihydroxy%5C-phenyl%5C-4%27%27%5C-O%5C-%CE%B2%5C-D%5C-glucopyranosyl%5C%29%5C-1%5C-propanone%5C+%5C%2813%5C%29%2C%5C+n%5C-aringenin%5C-7%5C-O%5C-%CE%B2%5C-D%5C-glucopyranoside%5C+%5C%2814%5C%29%2C%5C+vitexin%5C+%5C%288%5C-C%5C-%CE%B2%5C-D%5C-glucopyranosyl%5C+apigeni%5C-n%5C%29%5C+%5C%2815%5C%29%2C%5C+7%5C-O%5C-%CE%B2%5C-D%5C-glucopyranosyl%5C+chrysin%5C+%5C%2816%5C%29%2C%5C+isorhamnetin%5C+3%5C-O%5C-%CE%B1%5C-L%5C-rhamnopyra%5C-nosyl%5C-7%5C-O%5C-%CE%B2%5C-D%5C-glucopyranoside%5C+%5C%2817%5C%29%2C%5C+kaempferol%5C-3%5C-O%5C-%CE%B2%5C-D%5C-glucopyranoside%5C+%5C%2818%5C%29%5C+a%5C-nd%5C+kaempferol%5C-3%5C-O%5C-%CE%B2%5C-D%5C-%5C%286%27%27%27%27%5C-O%5C-trans%5C-p%5C-coumaroyl%5C%29%5C+glucopyranoside%5C+%5C%2819%5C%29.%5C+Compou%5C-nds%5C+2%5C-17%5C+were%5C+isolated%5C+from%5C+this%5C+plant%5C+for%5C+the%5C+first%5C+time.The%5C+second%5C+chapter%5C+describes%5C+chemical%5C+constituents%5C+from%5C+the%5C+leaves%5C+and%5C+twi%5C-gs%5C+of%5C+Gardenia%5C+sootepensis.%5C+Seven%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%2C%5C+incl%5C-uding%5C+oleanolic%5C+acid%5C+%5C%281%5C%29%2C%5C+coronalolide%5C+methyl%5C+ester%5C+%5C%282%5C%29%2C%5C+sootepin%5C+D%5C+%5C%283%5C%29%2C%5C+sootepi%5C-n%5C+F%5C+%5C%284%5C%29%2C%5C+sootepin%5C+G%5C+%5C%285%5C%29%2C%5C+sootepin%5C+H%5C+%5C%286%5C%29%5C+and%5C+sootepin%5C+I%5C+%5C%287%5C%29.%5C+4%5C-7%5C+are%5C+new%5C+com%5C-pounds.The%5C+third%5C+chapter%5C+describes%5C+chemical%5C+constituents%5C+from%5C+the%5C+fruits%5C+of%5C+Gardeni%5C-a%5C+jasminoides.%5C+Eight%5C+compounds%5C+were%5C+isolated.%5C+These%5C+compounds%5C+were%5C+identifi%5C-ed%5C+to%5C+be%5C+jasminodiol%5C+%5C%281%5C%29%2C%5C+syringaresinol%5C+%5C%282%5C%29%2C%5C+methyl%5C+%CE%B1%5C-D%5C-fructofuranoside%5C+%5C%283%5C%29%2C%5C+cl%5C-ethric%5C+acid%5C+%5C%284%5C%29%2C%5C+geniposide%5C%285%5C%29%2C%5C+diethylhexylphthalate%5C+%5C%286%5C%29%2C%5C+5%27%27%2C%5C+7%27%27%5C-octadecadienoic%5C+acid%2C%5C+2%2C%5C+3%5C-dihydroxypropyl%5C+ester%5C+%5C%287%5C%29%5C+and%5C+ursolic%5C+acid%5C+%5C%288%5C%29.The%5C+forth%5C+chapter%5C+describes%5C+chemical%5C+constituents%5C+from%5C+the%5C+root%5C+of%5C+Iris%5C+pseu%5C-dacorus.%5C+Four%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%2C%5C+including%5C+5%CE%B1%2C%5C+8%CE%B1%5C-epidio%5C-xyergosta%5C-6%2C%5C+22%5C-dien%5C-3%CE%B2%5C-ol%5C+%5C%281%5C%29%2C%5C+ayamenin%5C+B%5C+%5C%282%5C%29%2C%5C+2%5C-hydroxy%5C-benzoic%5C+acid%5C+%5C%283%5C%29%5C+and%5C+%CE%B2%5C-sitosterol%5C+%5C%284%5C%29.The%5C+fifth%5C+chapter%5C+reviewed%5C+the%5C+recent%5C+progress%5C+on%5C+seco%5C-cycloartane%5C+triterpene%5C+studies%2C%5C+their%5C+structure%5C+types%2C%5C+distribution%2C%5C+and%5C+biological%5C+activities%5C+were%5C+described."},{"jsname":"lastIndexed","jscount":"2024-06-27"}],"资助项目","dc.project.title_filter")'>
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为建设自主创新体系提供科技信息支撑
期刊论文
出版物, 3111, 期号: 0, 页码: 1—2
作者:
作者
Adobe PDF(328Kb)
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提交时间：2017/07/21
蒲公英植株中抗氧化成分的测定和比较
期刊论文
中国野生植物资源, 3111, 卷号: 20, 期号: 3, 页码: 18-19
作者:
陆长梅
;
芮海云
;
张卫明
;
吴国荣
;
宋宁丽
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提交时间：2017/07/21
铁皮石斛活性成分研究和对皮肤光老化的改善作用
学位论文
: 中国科学院大学, 2022
作者:
陈定康
Adobe PDF(4823Kb)
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提交时间：2024/05/14
铁皮石斛，超高效液相色谱与四级杆飞行时间质谱，联苄，抗光老化，SIRT3
Dendrobium officinale, UPLC-Q-TOF-MS, Bibenzyl derivatives, Anti-photoaging, SIRT3
基于代谢组学的牛油果化学品质的研究
学位论文
: 中国科学院大学, 2022
作者:
唐妮
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提交时间：2024/05/14
牛油果，代谢组学，营养物质，采收时间
Avocado, Metabonomics, Nutrients, Collecting time
海菜花的化学成分及其生物活性研究
学位论文
: 中国科学院大学, 2022
作者:
刘洪星
Adobe PDF(6132Kb)
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提交时间：2024/05/14
海菜花，Ottelione，二芳基庚烷，糖尿病，抗肿瘤
Ottelia acuminata, Ottelione, Diarylheptanoids, DM, Antitumor
西印度醋栗果实的化学成分研究
学位论文
: 中国科学院大学, 2022
作者:
胥佳
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大戟科，西印度醋栗，化学成分，生物活性，营养分析
Euphorbiaceae, Phyllanthus acidus (L.) Skeels, Chemical constituents, Biological activity, Nutritional analysis
松叶蕨和翠云草化学成分研究
学位论文
: 中国科学院大学, 2022
作者:
周志萍
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提交时间：2024/05/14
松叶蕨
Psilotum nudum (L.) Beauv
翠云草
Selaginella uncinata (Desv.) Spring
化学成分
Chemical compositions
细胞毒活性
Cytotoxic activity
NO生成抑制活性
NO inhibitory activity
T-型钙通道天然活性分子挖掘及其在治疗疼痛中的应用
学位论文
: 中国科学院大学, 2022
作者:
李松谕
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T-型钙通道，PPAP类化合物，黄酮类化合物
Key words: T-type calcium channel, PPAP, isoprenylated flavonoids
皱叶酸模根的化学成分及生物活性研究
学位论文
: 中国科学院大学, 2022
作者:
李永祥
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提交时间：2024/05/14
皱叶酸模，化学成分，生物活性，网络药理学
Rumex crispus L., Chemical composition, Biological activity, Network pharmacology
天麻花茎中活性成分及应用探索
学位论文
: 中国科学院大学, 2022
作者:
李芝兰
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提交时间：2024/05/14
天麻，天麻花茎，活性成分，药理活性
Gastrodia elata, The aerial parts of Gastrodia elata, Active ingredients, Pharmacological activity.
