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Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas 期刊论文
PHYTOCHEMISTRY, 2013, 卷号: 96, 页码: 265-272
作者:  Liu, Jie-Qing;  Yang, Yuan-Feng;  Li, Xu-Yang;  Liu, En-Qian;  Li, Zhong-Rong;  Zhou, Lin;  Li, Yan;  Qiu, Ming-Hua
浏览  |  Adobe PDF(915Kb)  |  收藏  |  浏览/下载：312/107  |  提交时间：2015/05/14
Jatropha Curcas  Euphorbiaceae  Rhamnofolane Diterpenoids  Cytotoxicity  
Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4 beta-Triazole Rings 期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 11, 页码: 13992-14012
作者:  Zi, Cheng-Ting;  Xu, Feng-Qing;  Li, Gen-Tao;  Li, Yan;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao
Adobe PDF(404Kb)  |  收藏  |  浏览/下载：205/55  |  提交时间：2015/05/13
Podophyllotoxin  4 Beta-triazole Ring  Click Chemistry  Anticancer Activity  
Three unusual sesquineolignans from Alpinia conchigera 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 卷号: 15, 期号: 8, 页码: 833-839
作者:  Xu, Jun-Ju;  Zhao, Hong-Mei;  Shen, Yong;  Chen, Jian-Hua;  Li, Yan;  Tan, Ning-Hua;  Yang, Sheng-Chao
浏览  |  Adobe PDF(118Kb)  |  收藏  |  浏览/下载：219/54  |  提交时间：2013/10/16
Zingiberaceae  Alpinia Conchigera  Sesquineolignans  Conchignans A-c  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：290/50  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.