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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations Eph antagonist and angiogenesis 期刊论文
出版物, 3111, 期号: 0, 页码: 1-32
作者:  I Hassan-Mohamed;  C Giorgio;  M Incerti;  S Russo;  D Pala;  E B Pasquale;  P Vicini;  E Barocelli;  S Rivara;  M Mor;  A Lodola;  M Tognolini
Adobe PDF(1403Kb)  |  收藏  |  浏览/下载:279/1  |  提交时间:2017/07/24
Eph Kinase  Ephrin  Small Molecules  Angiogenesis  Bile Acid  Lithocholic Acid  
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
作者:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
Adobe PDF(1198Kb)  |  收藏  |  浏览/下载:182/1  |  提交时间:2017/07/24
Abt-263  Sorafenib  Combination Therapy  Cancer  
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-42
作者:  C Pergola;  J Gerstmeier;  B Monch;  B Çaliskan;  S Luderer;  C Weinige;  D Barz;  J Maczewsky;  S Pace;  A Rossi;  L Sautebin;  E Banoglu;  O Werz
Adobe PDF(1387Kb)  |  收藏  |  浏览/下载:288/1  |  提交时间:2017/07/24
YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK 期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
作者:  Ling-Chu Chang;  Hui-Yi Lin;  Meng-Tung Tsai;  Ruey-Hwang Chou;  Fang-Yu Lee;  Che-Ming Teng;  Min-Tsang Hsieh;  Hsin-Yi Hung;  Li-Jiau Huang;  Yung-Luen Yu;  Sheng-Chu Kuo
Adobe PDF(1357Kb)  |  收藏  |  浏览/下载:310/1  |  提交时间:2017/07/24
Yc-1  Triple-negative Breast Cancer  Erk  Ezh2  C-cbl  
The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1 期刊论文
出版物, 2111, 页码: 1-44
作者:  1M S Grace;  T Lieu;  B Darby;  F C Abogadie;  N Veldhuis N W Bunnett;  P McIntyre
Adobe PDF(1611Kb)  |  收藏  |  浏览/下载:109/1  |  提交时间:2017/07/24
Transient Receptor Potential Ion Channel  Trpv4  Protease Activated Receptor  Par2  Pain  Tyrosine Kinase  Bafetinib  
The re‑emergence of natural products for drug discovery in the genomics era 期刊论文
Nature Reviews Drug Discovery, 2015, 页码: nrd4510
作者:  Alan L. Harvey
Adobe PDF(540Kb)  |  收藏  |  浏览/下载:81/0  |  提交时间:2017/08/22
Novel and highly potent antitumour natural products from cnidarians of marine origin 期刊论文
Nat Prod Res, 2014, 卷号: 28, 页码: 2237-2244
作者:  Boris Pejin
Adobe PDF(619Kb)  |  收藏  |  浏览/下载:28/0  |  提交时间:2017/08/22
Can we safely target the WNT pathway? 期刊论文
NATURE REVIEWS DRUG DISCOVERY, 2014, 卷号: 13, 页码: 513
作者:  Michael Kahn
Adobe PDF(1565Kb)  |  收藏  |  浏览/下载:58/0  |  提交时间:2017/08/18
Quantum dots (QDs) restrain human cervical carcinoma HeLa cell proliferation through inhibition of the ROCK-c-Myc signaling 期刊论文
Integr. Biol., 2013, 期号: 5, 页码: 590-596
Liqun Chen; Guangbo Qu; Changwen Zhang; Shuping Zhang; Jiuyang He; Nan Sang; Sijin Liu
Adobe PDF(3624Kb)  |  收藏  |  浏览/下载:78/2  |  提交时间:2014/01/06
WNT signalling pathways astherapeutic targets in cancer 期刊论文
NATURE REVIEWS CANCER, 2013, 卷号: 13, 期号: 0, 页码: 11—26
作者:  Jamie N. Anastas;  Randall T. Moon
Adobe PDF(498Kb)  |  收藏  |  浏览/下载:62/1  |  提交时间:2017/07/21