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Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 109, 页码: 104728
作者:  Ni,Dong-Xuan;  Wang,Qi;  Li,Yi-Ming;  Cui,Yi-Man;  Shen,Tian-Ze;  Li,Xiao-Li;  Sun,Han-Dong;  Zhang,Xing-Jie;  Zhang,Ruihan;  Xiao,Wei-Lie
收藏  |  浏览/下载：65/0  |  提交时间：2022/04/02
Natural products modification  HDAC inhibition  Inflammasome  Triterpenoid  SCHISANDRA-PROPINQUA  TRITERPENOIDS  MECHANISM  INJURY  
Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-beta 1 induced kidney proximal tubular cells 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105067
作者:  Song,Ying-Ying;  Jiang,Jian-Bing;  Yan,Yong-Ming;  Cheng,Yong-Xian
浏览  |  Adobe PDF(4755Kb)  |  收藏  |  浏览/下载：112/37  |  提交时间：2022/04/02
Belamcanda chinensis  Triterpenoids  TGF-beta 1  Kidney proximal tubular cells  TGF-BETA  TRITERPENOIDS  CONSTITUENTS  
Diarylheptanoid-chalcone hybrids with PTP1B and alpha-glucosidase dual inhibition from Alpinia katsumadai 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104683
作者:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Zhang,Xue-Mei;  Geng,Chang-An
浏览  |  Adobe PDF(2223Kb)  |  收藏  |  浏览/下载：131/53  |  提交时间：2022/04/02
Alpinia katsumadai  Katsumadainols A(1)-A(16)  PTP1B/TCPTP selective inhibitors  alpha-glucosidase inhibitors  Antidiabetic effects  THEORETICAL CALCULATION  ABSOLUTE-CONFIGURATION  SEEDS  BLEPHAROCALYXINS  ADDUCT  MOIETY  
FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105338
作者:  Peng,Xing-Rong;  Wang,Qian;  Wang,Hui-Rong;  Hu,Kun;  Xiong,Wen-Yong;  Qiu,Ming-Hua
浏览  |  Adobe PDF(7004Kb)  |  收藏  |  浏览/下载：97/14  |  提交时间：2022/04/02
Ganoderma applanatum  Meroterpenoid dimers  Molecular docking  Anti-lipogenesis  FPR2-based inflammation  INDUCED INSULIN-RESISTANCE  ADIPOCYTE DIFFERENTIATION  OBESITY  INFLAMMATION  DEFICIENCY  MACROPHAGES  ACTIVATION  EXPRESSION  LIGAND  MICE  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
浏览  |  Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：101/30  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun;  Zhao,Qin-Shi
浏览  |  Adobe PDF(3665Kb)  |  收藏  |  浏览/下载：80/13  |  提交时间：2022/04/02
Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN