中文版 | English

在结果中检索

KIB OpenIR

浏览/检索结果: 共4条，第1-4条 帮助

限定条件                        
已选(0)清除 条数/页：   排序方式：
Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells 期刊论文
CANCER SCIENCE, 2013, 卷号: 104, 期号: 12, 页码: 1697-1704
作者:  Liu, Jing-Lei;  Zeng, Guang-Zhi;  Liu, Xiao-Li;  Liu, Yong-Qiang;  Hu, Zhong-Guo;  Liu, Ying;  Tan, Ning-Hua;  Zhou, Guang-Biao
浏览  |  Adobe PDF(1224Kb)  |  收藏  |  浏览/下载：190/47  |  提交时间：2015/05/13
Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 15, 页码: 4297-4302
作者:  Chen, Wen;  Deng, Xiao-Yan;  Li, Yan;  Yang, Li-Juan;  Wan, Wei-Chao;  Wang, Xue-Quan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(820Kb)  |  收藏  |  浏览/下载：247/46  |  提交时间：2013/10/16
Hybrid Compound  Benzofuran  Imidazole  Triazole  Structure-activity Relationships  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：256/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2013, 卷号: 132, 期号: 3, 页码: 707-716
作者:  Kan, Winnie Lai Ting;  Yin, Chun;  Xu, Hong Xi;  Xu, Gang;  To, Kenneth Kin Wah;  Cho, Chi Hin;  Rudd, John Anthony;  Lin, Ge
浏览  |  Adobe PDF(826Kb)  |  收藏  |  浏览/下载：448/97  |  提交时间：2013/03/18
Guttiferone k  Anti-tumor  Colon Cancer  Apoptosis  Cell Cycle