Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells

	Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells
	Liu, Jing-Lei 1,2,3,4; Zeng, Guang-Zhi 5; Liu, Xiao-Li 6; Liu, Yong-Qiang 1,2,3; Hu, Zhong-Guo 1,2,3; Liu, Ying 1,2,3,4; Tan, Ning-Hua 5; Zhou, Guang-Biao 1,2,3
	2013-12-01
发表期刊	CANCER SCIENCE
卷号	104 期号:12 页码:1697-1704
摘要	Multiple myeloma (MM) is a currently incurable blood cancer. Here we tested the effects of a small compound bigelovin on MM cells, and reported that it caused cell cycle arrest and subsequently induced apoptosis. Bigelovin triggered proteolysis of E2F1, which could be inhibited by caspase inhibitor. To investigate the clinical relevance, the expression of E2F1 in MM specimens was tested, and the results showed that E2F1 was overexpressed in 25-57% of MM patients and was associated with higher International Staging System (ISS) stage. These results suggest that E2F1 may be important for MM pathogenesis, and bigelovin could serve as a lead compound for the development of E2F1 inhibitor.
收录类别	SCI
语种	英语
WOS记录号	WOS:000330243200020
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/19231
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Guangzhou Inst Biomed, Div Mol Carcinogenesis & Targeted Therapy Canc, Beijing, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Hlth, Div Mol Carcinogenesis & Targeted Therapy Canc, Beijing, Peoples R China 3.Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing, Peoples R China 4.Univ Sci & Technol China, Hefei 230026, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 6.Nanfang Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jing-Lei,Zeng, Guang-Zhi,Liu, Xiao-Li,et al. Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells[J]. CANCER SCIENCE,2013,104(12):1697-1704.
APA	Liu, Jing-Lei.,Zeng, Guang-Zhi.,Liu, Xiao-Li.,Liu, Yong-Qiang.,Hu, Zhong-Guo.,...&Zhou, Guang-Biao.(2013).Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells.CANCER SCIENCE,104(12),1697-1704.
MLA	Liu, Jing-Lei,et al."Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells".CANCER SCIENCE 104.12(2013):1697-1704.

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