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题名: Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells
作者: Liu, Jing-Lei1, 2, 3, 4; Zeng, Guang-Zhi5; Liu, Xiao-Li6; Liu, Yong-Qiang1, 2, 3; Hu, Zhong-Guo1, 2, 3; Liu, Ying1, 2, 3, 4; Tan, Ning-Hua5; Zhou, Guang-Biao1, 2, 3
刊名: CANCER SCIENCE
出版日期: 2013-12-01
卷号: 104, 期号:12, 页码:1697-1704
文章类型: Article
英文摘要: Multiple myeloma (MM) is a currently incurable blood cancer. Here we tested the effects of a small compound bigelovin on MM cells, and reported that it caused cell cycle arrest and subsequently induced apoptosis. Bigelovin triggered proteolysis of E2F1, which could be inhibited by caspase inhibitor. To investigate the clinical relevance, the expression of E2F1 in MM specimens was tested, and the results showed that E2F1 was overexpressed in 25-57% of MM patients and was associated with higher International Staging System (ISS) stage. These results suggest that E2F1 may be important for MM pathogenesis, and bigelovin could serve as a lead compound for the development of E2F1 inhibitor.
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: UBIQUITIN-PROTEASOME PATHWAY ; SESQUITERPENE LACTONES ; INULA-BRITANNICA ; DRUG-RESISTANCE ; GENE-EXPRESSION ; CYCLE CONTROL ; LUNG-CANCER ; APOPTOSIS ; DEGRADATION ; PROTEINS
收录类别: SCI
语种: 英语
WOS记录号: WOS:000330243200020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19231
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Guangzhou Inst Biomed, Div Mol Carcinogenesis & Targeted Therapy Canc, Beijing, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Hlth, Div Mol Carcinogenesis & Targeted Therapy Canc, Beijing, Peoples R China
3.Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Beijing, Peoples R China
4.Univ Sci & Technol China, Hefei 230026, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
6.Nanfang Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Liu, Jing-Lei,Zeng, Guang-Zhi,Liu, Xiao-Li,et al. Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells[J]. CANCER SCIENCE,2013,104(12):1697-1704.
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