Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum
Dong, Jinrun1; Yue, Grace Gar-Lee2,3; Lee, Julia Kin-Ming2,3; Lau, Clara Bik-San2,3; Qiu, Minghua1
Corresponding AuthorLau, Clara Bik-San(claralau@cuhk.edu.hk) ; Qiu, Minghua(mhchiu@mail.kib.ac.cn)
2020-01-17
Source PublicationMEDICINAL CHEMISTRY RESEARCH
ISSN1054-2523
Pages7
AbstractCynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-beta-cymaropyranoside (1), caudatin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study.
KeywordCynanchum otophyllum Neurotrophic activity Cytotoxicity Colon cancer cells
DOI10.1007/s00044-020-02506-7
Indexed BySCI ; SCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000507790700001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70629
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLau, Clara Bik-San; Qiu, Minghua
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum[J]. MEDICINAL CHEMISTRY RESEARCH,2020:7.
APA Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,Lau, Clara Bik-San,&Qiu, Minghua.(2020).Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum.MEDICINAL CHEMISTRY RESEARCH,7.
MLA Dong, Jinrun,et al."Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum".MEDICINAL CHEMISTRY RESEARCH (2020):7.
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