| Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum | |
Dong, Jinrun1; Yue, Grace Gar-Lee2,3; Lee, Julia Kin-Ming2,3; Lau, Clara Bik-San2,3; Qiu, Minghua1
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| Corresponding Author | Lau, Clara Bik-San(claralau@cuhk.edu.hk) ; Qiu, Minghua(mhchiu@mail.kib.ac.cn) |
| 2020-01-17 | |
| Source Publication | MEDICINAL CHEMISTRY RESEARCH
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| ISSN | 1054-2523 |
| Pages | 7 |
| Abstract | Cynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-beta-cymaropyranoside (1), caudatin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study. |
| Keyword | Cynanchum otophyllum Neurotrophic activity Cytotoxicity Colon cancer cells |
| DOI | 10.1007/s00044-020-02506-7 |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000507790700001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70629 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Lau, Clara Bik-San; Qiu, Minghua |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hong Kong, Peoples R China |
| Recommended Citation GB/T 7714 | Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum[J]. MEDICINAL CHEMISTRY RESEARCH,2020:7. |
| APA | Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,Lau, Clara Bik-San,&Qiu, Minghua.(2020).Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum.MEDICINAL CHEMISTRY RESEARCH,7. |
| MLA | Dong, Jinrun,et al."Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum".MEDICINAL CHEMISTRY RESEARCH (2020):7. |
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