Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus
Feng, Wenya1; Chen, Chunmei1; Mo, Shuyuan1; Qi, Changxing1; Gong, Jiaojiao1; Li, Xiao-Nian2; Zhou, Qun1; Zhou, Yuan1; Li, Dongyan3; Lai, Yongji4; Zhu, Hucheng1; Wang, Jianping1; Zhang, Yonghui1
Corresponding AuthorZhu, Hucheng(zhuhucheng@hust.edu.cn) ; Wang, Jianping(jpwang1001@163.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
2019-08-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume164Pages:184-191
AbstractEleven highly oxygenated meroterpenoids, named terreustoxins A - K, along with five known analogues, were isolated from the Antarctic fungus Aspergillus terreus. The structures and absolute configurations of these un-described compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Terreustoxins A - D are the first examples of meroterpenoids with two ortho-hydroxy groups at C-6 and C-7 in the terretonins family. Terreustoxin C and terretonin inhibited the proliferation of Con A-induced murine T cells at the concentration of 10 mu M.
KeywordAspergillus terreus (Trichocomaceae) Antarctic fungus Terreustoxins Immunosuppressive activity
DOI10.1016/j.phytochem.2019.05.015
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000475996800021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68260
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhu, Hucheng; Wang, Jianping; Zhang, Yonghui
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Feng, Wenya,Chen, Chunmei,Mo, Shuyuan,et al. Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus[J]. PHYTOCHEMISTRY,2019,164:184-191.
APA Feng, Wenya.,Chen, Chunmei.,Mo, Shuyuan.,Qi, Changxing.,Gong, Jiaojiao.,...&Zhang, Yonghui.(2019).Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus.PHYTOCHEMISTRY,164,184-191.
MLA Feng, Wenya,et al."Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus".PHYTOCHEMISTRY 164(2019):184-191.
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