Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces
He, Xin1,2; Wang, Yongjiang1; Luo, Rong-Hua3; Yang, Liu-Meng3; Wang, Li1; Guo, Dale2; Yang, Jing1; Deng, Yun2; Zheng, Yong-Tang3; Huang, Sheng-Xiong1
Corresponding AuthorHuang, Sheng-Xiong(sxhuang@mail.kib.ac.cn)
2019-07-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume82Issue:7Pages:1813-1819
AbstractEight new sulfur-bridged pyranonaphthoquinone (PNQ) dimers, naquihexcins C-J (1-8), a new PNQ monomer, naquihexcin K (10), and three known analogues (9, 11, and 12) were isolated from Streptomyces sp. KIB3133. The new structures were elucidated by interpretation of spectroscopic data. Dimer 4 was synthesized via a cascade S(N)2 reactions between two monomers and sodium sulfide, an approach motivated by the proposed biosynthetic pathway of dimeric pyranonaphthoquinones. Naquihexcin E (3) exhibited moderate HIV-1 inhibitory activity. Naquihexcins C (1), E (3), and I (7) showed inhibitory effects against two tumor cell lines (HL-60 and MCF-7) with IC50 values ranging from 1.4 to 16.1 mu M.
DOI10.1021/acs.jnatprod.9b00022
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000477917800010
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68185
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHuang, Sheng-Xiong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Sichuan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
He, Xin,Wang, Yongjiang,Luo, Rong-Hua,et al. Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(7):1813-1819.
APA He, Xin.,Wang, Yongjiang.,Luo, Rong-Hua.,Yang, Liu-Meng.,Wang, Li.,...&Huang, Sheng-Xiong.(2019).Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,82(7),1813-1819.
MLA He, Xin,et al."Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 82.7(2019):1813-1819.
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