KIB OpenIR  > 资源植物与生物技术所级重点实验室
Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum
Zhang, Dongdong1,2,3; Fu, Yao1,2,3; Yang, Jun1,2,3; Li, Xiao-Nian2,3; San, Myint Myint4; Oo, Thaung Naing4; Wang, Yuehu1,2,3; Yang, Xuefei1,2,3
Corresponding AuthorWang, Yuehu(wangyuehu@mail.kib.ac.cn) ; Yang, Xuefei(xuefei@mail.kib.ac.cn)
2019-06-02
Source PublicationMOLECULES
ISSN1420-3049
Volume24Issue:12Pages:23
AbstractFour new triterpenoids, 3 beta,12 beta,16 beta,21 beta,22-pentahydroxyhopane (1), 12 beta,16 beta,21 beta,22-tetrahydroxyhopan-3-one (2), 3-oxo-olean-12-ene-28,30-dioic acid (3), and 3 beta-hydroxyoleana-11,13(18)-diene-28,30-dioic acid 30-methyl ester (4); 21 new triterpenoid saponins, glinusopposides A-U (5-25); and 12 known compounds (26-37) were isolated from the whole plants of Glinus oppositifolius. The structures of the new compounds were elucidated based on the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. All compounds from the plants were measured for antifungal activities against Microsporum gypseum and Trichophyton rubrum. Glinusopposide B (6), glinusopposide Q (21), glinusopposide T (24), and glinusopposide U (25) showed strong inhibitory activities against M. gypseum (MIC50 7.1, 6.7, 6.8, and 11.1 mu M, respectively) and T. rubrum (MIC50 14.3, 13.4, 11.9, and 13.0 mu M, respectively). For those active compounds with an oleanane skeleton, glycosylation (21-26) or oxidation (3) of 3-OH was helpful in increasing the activity; replacement of the 30-methyl group (29) by a carboxymethyl group (26) enhanced the activity; the presence of 11,13(18) double bonds (20) decreased the activity.
KeywordGlinus oppositifolius triterpenoids and triterpenoid saponins antifungal activity
DOI10.3390/molecules24122206
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000473816900012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67885
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorWang, Yuehu; Yang, Xuefei
Affiliation1.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Forest Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
Recommended Citation
GB/T 7714
Zhang, Dongdong,Fu, Yao,Yang, Jun,et al. Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum[J]. MOLECULES,2019,24(12):23.
APA Zhang, Dongdong.,Fu, Yao.,Yang, Jun.,Li, Xiao-Nian.,San, Myint Myint.,...&Yang, Xuefei.(2019).Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum.MOLECULES,24(12),23.
MLA Zhang, Dongdong,et al."Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum".MOLECULES 24.12(2019):23.
Files in This Item: Download All
File Name/Size DocType Version Access License
Zhang-2019-Triterpen(1551KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Dongdong]'s Articles
[Fu, Yao]'s Articles
[Yang, Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Dongdong]'s Articles
[Fu, Yao]'s Articles
[Yang, Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Dongdong]'s Articles
[Fu, Yao]'s Articles
[Yang, Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Zhang-2019-Triterpenoids and Their Glycosides.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.